中华物理医学与康复杂志
中華物理醫學與康複雜誌
중화물리의학여강복잡지
CHINESE JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION
2014年
3期
181-184
,共4页
陈炳%叶祥明%陈建飞%张垣%吴登宠%杨堃%余梅%章国伟
陳炳%葉祥明%陳建飛%張垣%吳登寵%楊堃%餘梅%章國偉
진병%협상명%진건비%장원%오등총%양곤%여매%장국위
帕金森病痴呆%认知功能%康复%盐酸多奈哌齐
帕金森病癡呆%認知功能%康複%鹽痠多奈哌齊
파금삼병치태%인지공능%강복%염산다내고제
Parkinson's disease%Dementia%Cognition%Rehabilitation%Aricept
目的 比较盐酸多奈哌齐和认知功能康复训练治疗帕金森病痴呆(PDD)的疗效.方法 选取帕金森病(PD)合并轻中度痴呆患者50例,按随机数字表法分为认知功能康复训练组(训练组)24例和盐酸多奈哌齐治疗组(对照组)26例.训练组给予认知功能康复训练,对照组给予口服盐酸多奈哌齐治疗.2组患者均于治疗前和治疗第4、8、12周时采用蒙特利尔认知评估量表(MoCA)评估其认知功能,同时采用统一帕金森病评分量表(UPDRS)评估患者PD的严重程度.结果 治疗4、8、12周后,训练组患者的MoCA评分与组内治疗前比较,差异均有统计学意义(P<0.05);治疗8、12周后,对照组患者的MoCA评分与组内治疗前比较,差异均有统计学意义(P<0.05).治疗4周后,训练组患者的MoCA评分为(19.49±3.11)分,与对照组同时间点的(18.08 ±3.05)分比较,差异有统计学意义(P<0.05).治疗4周后,训练组患者UPDRS量表的精神、行为和情绪评分与组内治疗前以及对照组同时间点比较,差异均有统计学意义(P<0.05);治疗4、12周后,训练组患者UPDRS量表的运动检查评分与组内治疗前以及对照组同时间点比较,差异均有统计学意义(P<0.05).结论 认知功能康复训练或口服盐酸多奈哌齐治疗都对PDD有效,但前者起效更快.
目的 比較鹽痠多奈哌齊和認知功能康複訓練治療帕金森病癡呆(PDD)的療效.方法 選取帕金森病(PD)閤併輕中度癡呆患者50例,按隨機數字錶法分為認知功能康複訓練組(訓練組)24例和鹽痠多奈哌齊治療組(對照組)26例.訓練組給予認知功能康複訓練,對照組給予口服鹽痠多奈哌齊治療.2組患者均于治療前和治療第4、8、12週時採用矇特利爾認知評估量錶(MoCA)評估其認知功能,同時採用統一帕金森病評分量錶(UPDRS)評估患者PD的嚴重程度.結果 治療4、8、12週後,訓練組患者的MoCA評分與組內治療前比較,差異均有統計學意義(P<0.05);治療8、12週後,對照組患者的MoCA評分與組內治療前比較,差異均有統計學意義(P<0.05).治療4週後,訓練組患者的MoCA評分為(19.49±3.11)分,與對照組同時間點的(18.08 ±3.05)分比較,差異有統計學意義(P<0.05).治療4週後,訓練組患者UPDRS量錶的精神、行為和情緒評分與組內治療前以及對照組同時間點比較,差異均有統計學意義(P<0.05);治療4、12週後,訓練組患者UPDRS量錶的運動檢查評分與組內治療前以及對照組同時間點比較,差異均有統計學意義(P<0.05).結論 認知功能康複訓練或口服鹽痠多奈哌齊治療都對PDD有效,但前者起效更快.
목적 비교염산다내고제화인지공능강복훈련치료파금삼병치태(PDD)적료효.방법 선취파금삼병(PD)합병경중도치태환자50례,안수궤수자표법분위인지공능강복훈련조(훈련조)24례화염산다내고제치료조(대조조)26례.훈련조급여인지공능강복훈련,대조조급여구복염산다내고제치료.2조환자균우치료전화치료제4、8、12주시채용몽특리이인지평고량표(MoCA)평고기인지공능,동시채용통일파금삼병평분량표(UPDRS)평고환자PD적엄중정도.결과 치료4、8、12주후,훈련조환자적MoCA평분여조내치료전비교,차이균유통계학의의(P<0.05);치료8、12주후,대조조환자적MoCA평분여조내치료전비교,차이균유통계학의의(P<0.05).치료4주후,훈련조환자적MoCA평분위(19.49±3.11)분,여대조조동시간점적(18.08 ±3.05)분비교,차이유통계학의의(P<0.05).치료4주후,훈련조환자UPDRS량표적정신、행위화정서평분여조내치료전이급대조조동시간점비교,차이균유통계학의의(P<0.05);치료4、12주후,훈련조환자UPDRS량표적운동검사평분여조내치료전이급대조조동시간점비교,차이균유통계학의의(P<0.05).결론 인지공능강복훈련혹구복염산다내고제치료도대PDD유효,단전자기효경쾌.
Objective To compare the curative effects of cognitive rehabilitation training and oral administration of Aricept on dementia associated with Parkinson's disease (PD).Methods Fifty patients with Parkinson's disease and mild to moderate dementia were divided into an experimental group (24 cases) and a control group (26 cases).The experimental group was given cognition training while the control group was given oral Aricept (5 mg daily for 4 weeks followed by 10mg daily for 8 weeks).The cognitive function of the two groups was evaluated using the Montreal cognitive assessment (MoCA) before treatment and at the end of the 4th,8th and 12th week of treatment.The severity of the patients' PD was assessed with the unified Parkinson's disease rating scale (UPDRS).Results After 4,8 and 12 weeks of treatment,the average MoCA score of the experimental group had significantly improved compared with before treatment.The average MoCA score of the control group was significantly improved after 8 and 12 weeks.After 4 weeks of treatment the average MoCA score of the experimental group was significantly higher than that of the control group.After 4 weeks of training,the average spirit,behavior and emotion scores of the experimental group in the UPDRS were significantly higher than before treatment and also significantly higher than the control group's average scores.The motor scores showed no significant difference until after 4 and 12 weeks of treatment.Conclusion Both cognition training and Aricept can alleviate dementia associated with PD,but the former works faster and has no adverse effect on movement.