CAJ | 학술논문

目的分析2011年江苏省乙型流感病毒的血凝素(HA)和神经氨酸酶(NA)的分子流行特征.方法选择13株2011年江苏省不同地区、不同流行时间的乙型流感毒株进行全基因组测序,通过生物信息学方法对HA、NA分子流行特征进行分析.结果 13株乙型流感毒株中,10株属于Victoria系,3株属于Yamagata系.10株Victoria系毒株的NA基因来源于Yamagata系病毒,是基因重配流行株.与疫苗株相比,10株Victoria系毒株和3株Yamagata系毒株的HA蛋白分别在197和196位增加一个糖基化位点.结论 2011年江苏省乙型流感Victoria系和Yamagata系病毒同时流行,其中重配的Victoria系病毒占优势.
목적 분석2011년강소성을형류감병독적혈응소(HA)화신경안산매(NA)적분자류행특정.방법 선택13주2011년강소성불동지구、불동류행시간적을형류감독주진행전기인조측서,통과생물신식학방법대HA、NA분자류행특정진행분석.결과 13주을형류감독주중,10주속우Victoria계,3주속우Yamagata계.10주Victoria계독주적NA기인래원우Yamagata계병독,시기인중배류행주.여역묘주상비,10주Victoria계독주화3주Yamagata계독주적HA단백분별재197화196위증가일개당기화위점.결론 2011년강소성을형류감Victoria계화Yamagata계병독동시류행,기중중배적Victoria계병독점우세.
Objective To characterize the molecular characteristics of hemagglutinin (HA) and neuraminidase (NA) of influenza B viruses isolated in Jiangsu province,2011.Methods Thirteen strains of influenza B virus in different areas and epidemic period in Jiangsu province,2011 were selected for whole-genome sequencing,and analysis of molecule epidemic characteristics for HA and NA was carried out by bioinformatics method.Results Of the 13 randomly selected influeuza B strains,10 strains were assorted to Victoria lineage strains with NA genes from Yamagata lineage,and 3 strains belong to Yamagata lineage.Compared nucleotide and amino acid sequences of HA and NA genes with their vaccine strains respectiuely,196/197 glycosylation site appeared on HA1 gene in Yamagata/Victoria isolates virus.Conclusion Both B/Victoria and B/Yamagata lineage viruses co-circulated in Jiangsu province,and reassortant virus of Victoria lineage were predominant virus.