中华消化内镜杂志
中華消化內鏡雜誌
중화소화내경잡지
CHINESE JOURNAL OF DIGESTIVE ENDOSCOPY
2012年
7期
380-384
,共5页
郭妍%刘岩%路筝%王东%邹多武%刘枫%金震东%李淑德%湛先保%李兆申
郭妍%劉巖%路箏%王東%鄒多武%劉楓%金震東%李淑德%湛先保%李兆申
곽연%류암%로쟁%왕동%추다무%류풍%금진동%리숙덕%담선보%리조신
胆管癌%近距离放射疗法%支架%碘放射性同位素
膽管癌%近距離放射療法%支架%碘放射性同位素
담관암%근거리방사요법%지가%전방사성동위소
Cancer of bile duct%Brachytherapy%Stent%Iodine radioisotopes
目的 探讨125I放射性粒子支架治疗进展期肝外胆管癌的临床疗效.方法 回顾性分析15例不能外科手术切除的肝外胆管癌患者内镜下胆管放射性粒子支架置入治疗的资料,总结术后并发症发生情况和治疗效果、支架的通畅时间、患者生存期等.结果 15例患者共接受32次放射性粒子支架置入治疗,均顺利置入支架,没有发生消化道穿孔、出血、骨髓抑制等严重并发症.首次治疗平均实际吸收剂量为(56.55±17.42) Gy(7.86 ～ 82.48 Gy),粒子支架平均通畅时间为(117±105)d (8～295 d),患者中位生存期为420 d(90 ～ 1175 d),6例患者(40％)生存期超过了12个月.结论 125I放射性粒子支架治疗进展期肝外胆管癌是安全有效的治疗方法.
目的 探討125I放射性粒子支架治療進展期肝外膽管癌的臨床療效.方法 迴顧性分析15例不能外科手術切除的肝外膽管癌患者內鏡下膽管放射性粒子支架置入治療的資料,總結術後併髮癥髮生情況和治療效果、支架的通暢時間、患者生存期等.結果 15例患者共接受32次放射性粒子支架置入治療,均順利置入支架,沒有髮生消化道穿孔、齣血、骨髓抑製等嚴重併髮癥.首次治療平均實際吸收劑量為(56.55±17.42) Gy(7.86 ～ 82.48 Gy),粒子支架平均通暢時間為(117±105)d (8～295 d),患者中位生存期為420 d(90 ～ 1175 d),6例患者(40％)生存期超過瞭12箇月.結論 125I放射性粒子支架治療進展期肝外膽管癌是安全有效的治療方法.
목적 탐토125I방사성입자지가치료진전기간외담관암적림상료효.방법 회고성분석15례불능외과수술절제적간외담관암환자내경하담관방사성입자지가치입치료적자료,총결술후병발증발생정황화치료효과、지가적통창시간、환자생존기등.결과 15례환자공접수32차방사성입자지가치입치료,균순리치입지가,몰유발생소화도천공、출혈、골수억제등엄중병발증.수차치료평균실제흡수제량위(56.55±17.42) Gy(7.86 ～ 82.48 Gy),입자지가평균통창시간위(117±105)d (8～295 d),환자중위생존기위420 d(90 ～ 1175 d),6례환자(40％)생존기초과료12개월.결론 125I방사성입자지가치료진전기간외담관암시안전유효적치료방법.
Objective To investigate the safety and efficiency of 125I radioactive stents for advanced extra-hepatic cholangio-carcinoma.Methods We retrospectively reviewed data of 15 consecutive patients with advanced and un-resectable extra-hepatic cholangiocarcinoma,who were treated by radioactive stents.Postoperative complications,patency time of stents,and survival of the patients were assessed.Results Fifteen patients underwent 32 endoscopic sessions of radioactive stents placement.Successful operations were achieved in all patients,and there were no life-threatening complications including perforation,bleeding or bone marrow depression.The average patency time of radioactive stents was 117 ± 105 days (8-295 days).The actual radiation dose was 56.55 ± 17.42 Gy (7.86-82.48 Gy).The median survival time was 420 days (90-1175 days) and survival of 6 patients exceeded 12 months.Conclusion The 125I radioactive stent is safe and effective for patients with advanced unresectable extra-hepatic cholangio-carcinoma.
