CAJ | 학술논문

目的对超声内镜引导下细针穿刺(EUS-FNA)获得标本进行细胞学及组织学分析,并对两者进行初步比较.方法对2010年10月至2012年1月间经CT检查发现纵隔病变、腹膜后病变及胰腺病变的43例病例,予EUS-FNA取病理明确诊断,穿刺针为22 G活检针,操作时无病理科医生在场.穿刺获得的组织条置于福尔马林液中,剩余部分涂片,分别进行细胞学及组织学检查.结果 43例病例中,纵隔病变9例,腹膜后病变1例,胰腺占位30例,胰腺头部肥大2例,全胰腺肥大1例.细胞学诊断恶性22例,可疑恶性2例,少量异形细胞3例,未见瘤细胞16例；组织学诊断恶性肿瘤30例,可疑恶性1例,结节病2例,慢性炎症10例.细胞学的阳性率、敏感度及准确度分别为51％、59％、65％,组织学的阳性率、敏感度及准确度分别为74％、81％、84％,2组间差异有统计学意义(P＜0.05).结论 EUS-FNA组织学诊断的阳性率、敏感度及准确度均优于细胞学诊断.
목적 대초성내경인도하세침천자(EUS-FNA)획득표본진행세포학급조직학분석,병대량자진행초보비교.방법 대2010년10월지2012년1월간경CT검사발현종격병변、복막후병변급이선병변적43례병례,여EUS-FNA취병리명학진단,천자침위22 G활검침,조작시무병이과의생재장.천자획득적조직조치우복이마림액중,잉여부분도편,분별진행세포학급조직학검사.결과 43례병례중,종격병변9례,복막후병변1례,이선점위30례,이선두부비대2례,전이선비대1례.세포학진단악성22례,가의악성2례,소량이형세포3례,미견류세포16례；조직학진단악성종류30례,가의악성1례,결절병2례,만성염증10례.세포학적양성솔、민감도급준학도분별위51％、59％、65％,조직학적양성솔、민감도급준학도분별위74％、81％、84％,2조간차이유통계학의의(P＜0.05).결론 EUS-FNA조직학진단적양성솔、민감도급준학도균우우세포학진단.
Objective To evaluated diagnosis yield of cytological and histological analysis of endoscopic ultrasound guided fine needle aspiration (EUS-FNA).Methods A total of 43 patients who were clinically diagnosed as having mediastinal lesions,retroperitoneal lesions or pancreatic lesions by CT were recruited to the study.EUS-FNA was performed with standard 22G needle.Specimens were placed in formalin for histological analysis,and residual materials were prepared for cytologic analysis.Results Lesions were located in the mediastinum (n =9),the retroperitoneum (n =1),and pancreas (n =33).Cytologic diagnoses included malignancy (n =22),suspicious malignancy (n =2),atypical cell (n =3),absence of malignancy (n =16).Histologic diagnoses included malignancy (n =30),suspicious malignancy (n =1),sarcoidosis (n =2),chronic inflammation (n =10).The positive rates,sensitivities and accuracies of cytology and histology were 51％,59％,65％ and 74％,81％,84％,respectively.Conclusion The positive rate,sensitivity and accuracy of histology of EUS-FNA is superior to cytology.