CAJ | 학술논문

目的基于多项式曲线回归方程对治疗幽门螺杆菌感染常用抗生素的耐药趋势进行分析预测,为临床用药提供参考.方法分别计算2007年至2012年临床分离的3496株幽门螺杆菌对不同抗生素的耐药率,对每两种药物的耐药趋势做相关分析,并对每种药物的耐药率分别建立对数曲线、指数曲线、倒指数曲线、多项式曲线、S型曲线进行回归分析,并对未来两年幽门螺杆菌感染情况进行预测.结果 2007年到2012年药敏试验结果显示,阿莫仙、庆大霉素和痢特灵对幽门螺杆菌有较强的抗菌活性,耐药率较低；而左氧氟沙星和克拉霉素耐药率有逐年升高的趋势；甲硝唑耐药率一直维持在较高水平.预测2013年克拉霉素、甲硝唑、左氧氟沙星、阿莫西林、庆大霉素和痢特灵的耐药率分别为21.49％、95.47％、20.70％、0.10％、0.09％、0.10％,结果与张建中等人对中国东南地区幽门螺杆菌感染率的初步调查情况一致.结论幽门螺杆菌的耐药率随时间的变化存在一定的量化关系,所建立的模型能较好预测未来幽门螺杆菌耐药率的趋势,可以指导临床轮换、限制使用抗菌药物,减少耐药菌的产生.
목적 기우다항식곡선회귀방정대치료유문라간균감염상용항생소적내약추세진행분석예측,위림상용약제공삼고.방법 분별계산2007년지2012년림상분리적3496주유문라간균대불동항생소적내약솔,대매량충약물적내약추세주상관분석,병대매충약물적내약솔분별건립대수곡선、지수곡선、도지수곡선、다항식곡선、S형곡선진행회귀분석,병대미래량년유문라간균감염정황진행예측.결과 2007년도2012년약민시험결과현시,아막선、경대매소화리특령대유문라간균유교강적항균활성,내약솔교저；이좌양불사성화극랍매소내약솔유축년승고적추세；갑초서내약솔일직유지재교고수평.예측2013년극랍매소、갑초서、좌양불사성、아막서림、경대매소화리특령적내약솔분별위21.49％、95.47％、20.70％、0.10％、0.09％、0.10％,결과여장건중등인대중국동남지구유문라간균감염솔적초보조사정황일치.결론 유문라간균적내약솔수시간적변화존재일정적양화관계,소건립적모형능교호예측미래유문라간균내약솔적추세,가이지도림상륜환、한제사용항균약물,감소내약균적산생.
Objective Study the drug resistance trend of Helicobacter pylori (H.pylori) based on polynomial regression equation to provide reference for clinical medication.Methods A total of 3496 clinical isolates of H.pylori collected from 2007 to 2012 were used for drug sensitivity test of six common-used drugs to evaluate the resistance rate of each drug.Correlation analysis were performed on each of the two drugs.Constructed log curve,exponential curve,inverted exponential curve,polynomial curve and sigmoid curve for each kind of drug resistance rate and did regression analysis for each drug resistance rate.Results According to the results of drug sensitivity test from 2007 to 2012,amoxicillin,furazolidone and gentamicin had strong antibacterial activity to H.pylori and got a lower drug resistance rate.The resistance rate of levofloxacin and clarithromycin were increasing year by year and the resistance of metronidazole had been maintained at a high level.The predictive drug resistance rate of clarithromycin,metronidazole,levofloxacin,amoxycillin,gentamicin and furaxone in 2013 were 21.49％,95.47％,20.70％,0.10％,0.09％ and 0.10％,respectively.The results were consistent with those of H.pylori infection rate in Southeast China performed by Jianzhong Zhang.Conclusion A certain quantitative relationship exists between the time and the helicobacter resistance rate.The established model can be used to predict the future trend of H.pylori resistance rate.It can be used to guide clinical rotation,the restriction of the use of antibiotics,and to reduce the generation of antibiotic resistant bacteria.