中华消化内镜杂志
中華消化內鏡雜誌
중화소화내경잡지
CHINESE JOURNAL OF DIGESTIVE ENDOSCOPY
2013年
7期
369-371
,共3页
李汛%严俊%孟文勃%张磊%周文策%朱克祥%朱晓亮%何雯婷%白仲添
李汛%嚴俊%孟文勃%張磊%週文策%硃剋祥%硃曉亮%何雯婷%白仲添
리신%엄준%맹문발%장뢰%주문책%주극상%주효량%하문정%백중첨
胆管癌%血清%胆汁%CA19-9%诊断
膽管癌%血清%膽汁%CA19-9%診斷
담관암%혈청%담즙%CA19-9%진단
Cholangiocarcinoma%Serum%Bile%CA19-9%Diagnosis
目的 探讨血清、胆汁CA19-9水平对胆管癌的早期诊断和鉴别诊断的价值.方法 对82例胆道恶性病变患者和85例胆道良性疾病者测定血清和胆汁的CA19-9水平,进行对比分析和评价.结果 恶性组患者血清、胆汁CA19-9水平均明显高于良性组患者(P＜0.001)；胆汁CA19-9诊断胆管癌的ROC曲线下面积为0.764,诊断价值高于血清的0.701；根据诊断评价指标,胆汁CA19-9灵敏度、特异度、符合率、阳性预测值和阴性预测值(57.90％、95.50％、77.25％、92.30％、70.43％)均高于血液CA19-9(50.90％,89.10％,70.66％,82.35％,65.62％),两项联合检测灵敏度、符合率及阴性预测值均有不同程度提高.结论 选择血清、胆汁CA19-9进行联合检测,在胆管癌的早期筛检中具有重要参考价值.
目的 探討血清、膽汁CA19-9水平對膽管癌的早期診斷和鑒彆診斷的價值.方法 對82例膽道噁性病變患者和85例膽道良性疾病者測定血清和膽汁的CA19-9水平,進行對比分析和評價.結果 噁性組患者血清、膽汁CA19-9水平均明顯高于良性組患者(P＜0.001)；膽汁CA19-9診斷膽管癌的ROC麯線下麵積為0.764,診斷價值高于血清的0.701；根據診斷評價指標,膽汁CA19-9靈敏度、特異度、符閤率、暘性預測值和陰性預測值(57.90％、95.50％、77.25％、92.30％、70.43％)均高于血液CA19-9(50.90％,89.10％,70.66％,82.35％,65.62％),兩項聯閤檢測靈敏度、符閤率及陰性預測值均有不同程度提高.結論 選擇血清、膽汁CA19-9進行聯閤檢測,在膽管癌的早期篩檢中具有重要參攷價值.
목적 탐토혈청、담즙CA19-9수평대담관암적조기진단화감별진단적개치.방법 대82례담도악성병변환자화85례담도량성질병자측정혈청화담즙적CA19-9수평,진행대비분석화평개.결과 악성조환자혈청、담즙CA19-9수평균명현고우량성조환자(P＜0.001)；담즙CA19-9진단담관암적ROC곡선하면적위0.764,진단개치고우혈청적0.701；근거진단평개지표,담즙CA19-9령민도、특이도、부합솔、양성예측치화음성예측치(57.90％、95.50％、77.25％、92.30％、70.43％)균고우혈액CA19-9(50.90％,89.10％,70.66％,82.35％,65.62％),량항연합검측령민도、부합솔급음성예측치균유불동정도제고.결론 선택혈청、담즙CA19-9진행연합검측,재담관암적조기사검중구유중요삼고개치.
Objective To evaluate the value of the levels of CA19-9 in the serum and bile for diagnosis of diseases of billiary system.Methods Concentration of serum and bile CA19-9 was determined in 82 patients with cholangiocarcinoma and 85 patients with benign disease,and the results were being analyzed and evaluated by statistics.Results The level of serum and bile CA19-9 in diseases of cholangiocarcinoma was higher than benign disease (P ＜0.001),and the diagnostic value of bile CA19-9 was higher than serum CA19-9 with ROC.In accordance with evaluation indicators,the sensitivity,specificity,coincidence rate,positive predictive rate and negative predictive rate of bile CA19-9 were all higher than serum.And the sensitivity,coincidence rate and negative predictive rate were enhanced after combined measurement of serum and bile CA19-9.Conclusion The way of combined measurement of serum and bile CA19-9 is an important reference in early screening cholangiocarcinoma.
