国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
18期
2840-2843
,共4页
慢性阻塞性肺疾病%前列地尔%白介素-8%肿瘤坏死因子-α
慢性阻塞性肺疾病%前列地爾%白介素-8%腫瘤壞死因子-α
만성조새성폐질병%전렬지이%백개소-8%종류배사인자-α
Chronic obstructive pulmonary disease%Alprostadil%TNF-α%IL-8
目的 观察前列地尔注射液治疗慢性阻塞性肺疾病急性加重期的临床疗效.方法 将78例慢性阻塞性肺疾病急性加重期患者随机分为前列地尔治疗组和对照组,对照组采用常规内科综合治疗,治疗组在对照组治疗的基础上加用前列地尔注射液静脉注射,监测两组患者.结果 治疗组总有效率为89.74％,明显优于对照组76.92％ (P＜0.05),治疗组在改善血液流变学、血气分析方面明显优于对照组(P＜0.05),且能显著降低CRP、TNF-α、IL-8含量(P＜0.01),明显降低肺动脉压(P＜0.01).结论 慢性阻塞性肺疾病急性加重期在常规治疗的基础上加用前列地尔注射液有较好的临床疗效,其作用机制可能在于通过扩血管作用抑制血小板凝集、降低血黏度和改善红细胞的变形能力,改善血液流变学.
目的 觀察前列地爾註射液治療慢性阻塞性肺疾病急性加重期的臨床療效.方法 將78例慢性阻塞性肺疾病急性加重期患者隨機分為前列地爾治療組和對照組,對照組採用常規內科綜閤治療,治療組在對照組治療的基礎上加用前列地爾註射液靜脈註射,鑑測兩組患者.結果 治療組總有效率為89.74％,明顯優于對照組76.92％ (P＜0.05),治療組在改善血液流變學、血氣分析方麵明顯優于對照組(P＜0.05),且能顯著降低CRP、TNF-α、IL-8含量(P＜0.01),明顯降低肺動脈壓(P＜0.01).結論 慢性阻塞性肺疾病急性加重期在常規治療的基礎上加用前列地爾註射液有較好的臨床療效,其作用機製可能在于通過擴血管作用抑製血小闆凝集、降低血黏度和改善紅細胞的變形能力,改善血液流變學.
목적 관찰전렬지이주사액치료만성조새성폐질병급성가중기적림상료효.방법 장78례만성조새성폐질병급성가중기환자수궤분위전렬지이치료조화대조조,대조조채용상규내과종합치료,치료조재대조조치료적기출상가용전렬지이주사액정맥주사,감측량조환자.결과 치료조총유효솔위89.74％,명현우우대조조76.92％ (P＜0.05),치료조재개선혈액류변학、혈기분석방면명현우우대조조(P＜0.05),차능현저강저CRP、TNF-α、IL-8함량(P＜0.01),명현강저폐동맥압(P＜0.01).결론 만성조새성폐질병급성가중기재상규치료적기출상가용전렬지이주사액유교호적림상료효,기작용궤제가능재우통과확혈관작용억제혈소판응집、강저혈점도화개선홍세포적변형능력,개선혈액류변학.
Objective To observe the effect of alprostadil injection for chronic obstructive pulmonary disease in acute exacerbation period.Methods Seventy-eight cases of chronic obstructive pulmonary disease in acute exacerbation period were randomly divided into a treatment and a control group.The control group received conventional medicine treatment.In addition,the treatment group treated with alprostadil injection.Both groups' patients were monitored.Results The total effective rate was 89.74％ in the treatment group and was 76.92％ in the control group,with a statistical difference (P＜0.05).The blood rheology and blood gas analysis were btter and the levels of CRP,TNF-α,and IL-8 and the pulmonary artery pressure were significantly lower in the treatment group than in the control group (P＜0.05,P＜0.01).Conclusion Conventional therapy combined with alprostadil injection for chronic obstructive pulmonary disease in acute exacerbation period has better clinical efficacy.Its mechanism may lie in the expansion of blood vessels,inhibition of platelet aggregation,reducing blood viscosity,improving erythrocyte deformation ability and blood rheology.
