中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2013年
2期
111-114
,共4页
程浩%贾喜花%郑淑君%张晓伟%张金库
程浩%賈喜花%鄭淑君%張曉偉%張金庫
정호%가희화%정숙군%장효위%장금고
胃肿瘤%端粒,末端转移酶%ATP结合匣式转运子%药物耐受性%预后
胃腫瘤%耑粒,末耑轉移酶%ATP結閤匣式轉運子%藥物耐受性%預後
위종류%단립,말단전이매%ATP결합갑식전운자%약물내수성%예후
Stomach neoplasms%Telomerase%ATP-binding cassette transporters%Drug tolerance%Prognosis
目的 检测胸苷酸合成酶(TS)和三磷酸腺苷结合转运蛋白G超家族成员2(ABCG2)在进展期胃癌中的表达,探讨其与临床病理特征的关系.方法 收集80例进展期胃癌患者的手术标本,采用免疫组织化学方法,在胃癌组织和相应癌旁正常组织中检测TS和ABCG2的表达,在胃癌组织中检测P-糖蛋白的表达.分析TS、ABCG2表达与临床病理特征、P-糖蛋白表达的相关性.两组间比较行x2检验,多组间比较行Kruskal-Wallis H检验.结果 胃癌组织中TS和ABCG2的总阳性率[85.0％(68/80)和90.0％ (72/80)]均高于癌旁正常组织[62.5％(50/80)和78.7％ (63/80)],差异均有统计学意义(x2=11.466和16.463,P=0.009和0.001).TS和ABCG2在胃癌组织中的表达水平均与肿瘤TNM分期、分化程度、浸润深度密切相关(TS的x2=30.686、49.823、40.545,ABCG2的x2=48.192、64.722、47.512;P均＜0.01),肿瘤分期越晚、分化程度越差、浸润越深,二者的表达水平越高.胃癌组织中TS和ABCG2的表达水平均与P-糖蛋白表达水平相关(x2=43.977和29.509,P均＜0.01).结论 TS和ABCG2有可能成为判断胃癌恶性程度、进展、耐药及预后的指标.
目的 檢測胸苷痠閤成酶(TS)和三燐痠腺苷結閤轉運蛋白G超傢族成員2(ABCG2)在進展期胃癌中的錶達,探討其與臨床病理特徵的關繫.方法 收集80例進展期胃癌患者的手術標本,採用免疫組織化學方法,在胃癌組織和相應癌徬正常組織中檢測TS和ABCG2的錶達,在胃癌組織中檢測P-糖蛋白的錶達.分析TS、ABCG2錶達與臨床病理特徵、P-糖蛋白錶達的相關性.兩組間比較行x2檢驗,多組間比較行Kruskal-Wallis H檢驗.結果 胃癌組織中TS和ABCG2的總暘性率[85.0％(68/80)和90.0％ (72/80)]均高于癌徬正常組織[62.5％(50/80)和78.7％ (63/80)],差異均有統計學意義(x2=11.466和16.463,P=0.009和0.001).TS和ABCG2在胃癌組織中的錶達水平均與腫瘤TNM分期、分化程度、浸潤深度密切相關(TS的x2=30.686、49.823、40.545,ABCG2的x2=48.192、64.722、47.512;P均＜0.01),腫瘤分期越晚、分化程度越差、浸潤越深,二者的錶達水平越高.胃癌組織中TS和ABCG2的錶達水平均與P-糖蛋白錶達水平相關(x2=43.977和29.509,P均＜0.01).結論 TS和ABCG2有可能成為判斷胃癌噁性程度、進展、耐藥及預後的指標.
목적 검측흉감산합성매(TS)화삼린산선감결합전운단백G초가족성원2(ABCG2)재진전기위암중적표체,탐토기여림상병리특정적관계.방법 수집80례진전기위암환자적수술표본,채용면역조직화학방법,재위암조직화상응암방정상조직중검측TS화ABCG2적표체,재위암조직중검측P-당단백적표체.분석TS、ABCG2표체여림상병리특정、P-당단백표체적상관성.량조간비교행x2검험,다조간비교행Kruskal-Wallis H검험.결과 위암조직중TS화ABCG2적총양성솔[85.0％(68/80)화90.0％ (72/80)]균고우암방정상조직[62.5％(50/80)화78.7％ (63/80)],차이균유통계학의의(x2=11.466화16.463,P=0.009화0.001).TS화ABCG2재위암조직중적표체수평균여종류TNM분기、분화정도、침윤심도밀절상관(TS적x2=30.686、49.823、40.545,ABCG2적x2=48.192、64.722、47.512;P균＜0.01),종류분기월만、분화정도월차、침윤월심,이자적표체수평월고.위암조직중TS화ABCG2적표체수평균여P-당단백표체수평상관(x2=43.977화29.509,P균＜0.01).결론 TS화ABCG2유가능성위판단위암악성정도、진전、내약급예후적지표.
Objective To investigate the expressions of thymidylate synthase (TS) and adenosine triphosphate (ATP)-binding cassette superfamily G member 2 (ABCG2) in advanced gastric cancer (GC) and to explore their correlation with clinical pathological features.Methods A total of 80surgical specimens of advanced gastric cancer patients were collected.The expressions of TS and ABCG2 in gastric cancer tissues and adjacent normal gastric tissues were detected by immunohistochemical method.The expression of P-glycoprotein in gastric cancer tissues was also examined.The correlations between TS,ABCG2 and clinical pathological features and P-glycoprotein were analyzed.Chi-square test was performed for two groups comparison and Kruskal-Wallis H test were used for multi-groups comparison.Results The positive rates of both TS and ABCG2 in gastric cancer tissues [85.0％ (68/80) and 90.0％ (72/80)] were higher than those of adjacent normal gastric tissues [62.5 ％ (50/80) and 78.7 ％ (63/80)],the differences were statistically significant (x2 =11.466 and 16.463,P=0.009 and 0.001).There were close correlation between the expression of TS,ABCG2 and tumor TNM stage,differentiation status,invasion depth (TS:x2 =30.686,61.470 and 40.545 ; ABCG2:x2=48.192,63.150 and 47.512; all P＜0.01).The later the tumor staged,the worse the cells differentiated and the deeper the tumor invaded,the higher level they expressed.Both TS and ABCG2expressions in gastric cancer tissues were correlated with the expression level of P glycoprotein (x2 =43.977and 29.509,both P＜0.01).Conclusion TS and ABCG2 may be potential indexes to predict the degree of malignancy,progression,drug resistance and prognosis in gastric cancer.
