残胃癌患者的生命质量评价
잔위암환자적생명질량평개
Evaluation of life quality in patients with gastric remnant cancer
  • 万方数据
    中华消化杂志 중화소화잡지
    Chinese Journal of Digestion
    2013年 3期 155-159 ,共5页

    尹曙明%张赣生%马海芬%黄一沁%陈洁%保志军%于晓峰

    윤서명%장공생%마해분%황일심%진길%보지군%우효봉

    胃肿瘤%胃切除术%生活质量%问卷调查 胃腫瘤%胃切除術%生活質量%問捲調查
    위종류%위절제술%생활질량%문권조사
    Stomach neoplasms%Gastrectomy%Quality of life%Questionnaires
    目的 研究残胃癌患者的健康相关生命质量(HRQoL)及其影响因素.方法 选取因早期胃癌接受胃大部切除术≥10年者130例,根据术后残胃是否发生癌变分为残胃癌组80例和残胃组50例.2组均接受癌症普适性量表生命质量测定量表(QLQ)-C30和胃癌特异性量表QLQ-STO22调查,评价其HRQoL.正态分布数据两组间比较行t检验.非正态分布数据两组间比较行Wilcoxon秩和检验.采用最优尺度回归分析筛选HRQoL相关的临床影响因素.结果 所有研究对象均完成量表调查.与健康对照组比较,残胃癌组总体生命质量评价、躯体功能、角色功能、情绪功能、认知功能、社会功能评分皆较低,差异均有统计学意义(t=-6.678、-7.111、-10.605、-5.748、-4.765、-21.170,P均＜0.01),疲倦、疼痛、腹泻、恶心与呕吐、食欲不振、经济困难、吞咽困难、腹痛、反流症状、饮食受限、焦虑、身体外观、脱发评分皆较高,差异均有统计学意义(t=6.925、4.218、4.728,Z=-5.236、-7.890、-7.698、-10.058、-3.612、-6.914、-9.711、9.940、-7.987、-4.966,P均＜0.01).与残胃组比较,残胃癌组总体生命质量评价、躯体功能、角色功能、情绪功能、认知功能、社会功能评分皆较低,差异均有统计学意义(t=-5.861、-5.821、-7.077、-7.999、-2.808、-5.710,P均＜0.01),疲倦、疼痛、恶心与呕吐、食欲不振、经济困难、吞咽困难、饮食受限、焦虑、身体外观、脱发评分皆较高,差异均有统计学意义(t=9.363、6.842,Z=-2.654、-6.256、-3.266、-4.132、-2.854、-7.996、-4.258、-2.005,P均＜0.01).与健康对照组比较,残胃组社会功能评分较低,差异有统计学意义(t=-9.820,P＜0.01),腹泻、恶心与呕吐、经济困难、吞咽困难、反流症状、饮食受限、身体外观、脱发评分皆较高,差异均有统计学意义(t=3.020,Z=-1.981、-3.775、-6.505、-6.098、-8.032、-3.369、-3.147,P均＜0.05),疲倦和疼痛的症状评分则较低,差异均有统计学意义(t=-2.890、-2.439,P均＜0.05).患者的HRQoL与学历、婚姻状况、家庭收入、残胃病程均正相关.结论 残胃癌患者的HRQoL均有不同程度下降.学历、家庭收入、残胃病程、婚姻状况等因素会影响残胃癌患者的HRQoL.
    목적 연구잔위암환자적건강상관생명질량(HRQoL)급기영향인소.방법 선취인조기위암접수위대부절제술≥10년자130례,근거술후잔위시부발생암변분위잔위암조80례화잔위조50례.2조균접수암증보괄성량표생명질량측정량표(QLQ)-C30화위암특이성량표QLQ-STO22조사,평개기HRQoL.정태분포수거량조간비교행t검험.비정태분포수거량조간비교행Wilcoxon질화검험.채용최우척도회귀분석사선HRQoL상관적림상영향인소.결과 소유연구대상균완성량표조사.여건강대조조비교,잔위암조총체생명질량평개、구체공능、각색공능、정서공능、인지공능、사회공능평분개교저,차이균유통계학의의(t=-6.678、-7.111、-10.605、-5.748、-4.765、-21.170,P균＜0.01),피권、동통、복사、악심여구토、식욕불진、경제곤난、탄인곤난、복통、반류증상、음식수한、초필、신체외관、탈발평분개교고,차이균유통계학의의(t=6.925、4.218、4.728,Z=-5.236、-7.890、-7.698、-10.058、-3.612、-6.914、-9.711、9.940、-7.987、-4.966,P균＜0.01).여잔위조비교,잔위암조총체생명질량평개、구체공능、각색공능、정서공능、인지공능、사회공능평분개교저,차이균유통계학의의(t=-5.861、-5.821、-7.077、-7.999、-2.808、-5.710,P균＜0.01),피권、동통、악심여구토、식욕불진、경제곤난、탄인곤난、음식수한、초필、신체외관、탈발평분개교고,차이균유통계학의의(t=9.363、6.842,Z=-2.654、-6.256、-3.266、-4.132、-2.854、-7.996、-4.258、-2.005,P균＜0.01).여건강대조조비교,잔위조사회공능평분교저,차이유통계학의의(t=-9.820,P＜0.01),복사、악심여구토、경제곤난、탄인곤난、반류증상、음식수한、신체외관、탈발평분개교고,차이균유통계학의의(t=3.020,Z=-1.981、-3.775、-6.505、-6.098、-8.032、-3.369、-3.147,P균＜0.05),피권화동통적증상평분칙교저,차이균유통계학의의(t=-2.890、-2.439,P균＜0.05).환자적HRQoL여학력、혼인상황、가정수입、잔위병정균정상관.결론 잔위암환자적HRQoL균유불동정도하강.학력、가정수입、잔위병정、혼인상황등인소회영향잔위암환자적HRQoL.
    Objective To investigate the health-related quality of life (HRQoL) and its influencing factors in patients with gastric remnant cancer (GRC).Methods A total of 130 patients received gastrectomy more than 10 years ago because of early gastric cancer.According to the gastric remnant canceration after the surgery,patients were divided into GRC group (80 cases) and gastric remnant group (50 cases).Both the patients of these two groups accepted questionnaires of cancer patients' quality of life questionnaire (QLQ) C30 and gastric cancer specific questionnaire QLQ-STO22,the HRQoL were evaluated.The comparison between two groups with normal distribution of data was aralyzed by t test.Wilcoxon rank sum test was applied for the comparison between two groups with non-normal distribution of data.Optimal scaling regression analysis was used for screening HRQoL related clinical influencing factors.Results All the research objectives finished the questionnaires survey.Compared with health control group,the scores of GRC group were lower,which included quality of life evaluation,physical function,role function,emotional function,cognitive function and social function,and the differences were statistically significant (t =-6.678,-7.111,-10.605,-5.748,-4.765 and-21.170,all P＜0.01).The scores of fatigue,pain,diarrhea,nausea and vomiting,loss of appetite,economic difficulties,dysphagia,abdominal pain,reflux symptoms,diet restricted,anxiety,physical appearance and hair loss were higher,and the differences were significant (t=6.925,4.218,4.728 and Z=-5.236,-7.890,-7.698,-10.058,-3.612,-6.914,-9.711,9.940,-7.987 and-4.966,all P＜0.01).Compared with gastric remnant group,the scores of GRC group were lower,which included quality of life evaluation,physical function,role function,emotional function,cognitive function and social function,and the differences were statistically significant (t=-5.861,-5.821,-7.077,-7.999,-2.808and-5.710,all P＜0.01).However the scores of fatigue,pain,diarrhea,nausea and vomiting,loss of appetite,economic difficulties,dysphagia,diet restricted,anxiety,physical appearance and hair loss were higher,and the differences were significant (t=9.363,6.842 and Z=-2.654,-6.256,-3.266,-4.132,-2.854,-7.996,-4.258 and-2.005,all P＜0.01).Compared with health control group,the score of social function of gastric remnant group was lower and the difference was significant (t =-9.820,P＜ 0.01); the scores of diarrhea,nausea and vomiting,economic difficulties,dysphagia,reflux symptoms,diet restricted,physical appearance and hair loss were higher,the differences were statistical significant (t=3.020 and Z=-1.981,-3.775,-6.505,-6.098,-8.032,-3.369 and-3.147,all P＜0.05) ; the symptom scores of fatigue and pain were lower,the differences were significant (t=-2.890 and-2.439,all P＜0.05).HRQoL of patients was positively correlated with education degree,marital status,family income and the disease course of gastric remnant.Conclusions HRQoL of GRC patients decreased to certain degree.Education degree,marital status,family income and the disease course of gastric remnant were the influential factors of HRQoL in GRC patients.
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