CAJ | 학술논문

目的探讨异体骨异位埋置预制骨皮瓣的可行性. 方法从2010年11月至2011年7月,用广西巴马小型猪为实验动物,先制作深低温冷冻异体骨备用；异体骨经复温后置于旋髂浅动脉供养的皮瓣组织内,按植入部位不同分3组:皮下组(A组)、深筋膜下组(B组)、肌内组(C组),术后培养观察.指标:异体骨ECT显像(分别于术后第4周、第8周、第12周),血管造影检查、异体骨病理学检查(术后第12周). 结果 3组预制骨皮瓣术后ECT扫描显示:第8周和第12周异体骨植入部位放射性较4周时增高,差异有统计学意义(P＜0.05)；血管造影显示在皮下组织、筋膜下组织、肌肉组织内的异体骨均有血管化,并与相应区域旋髂浅动脉建立血管联系；病理检查可见异体骨在筋膜下组织和肌肉组织内血管化作用和诱导新骨形成较明显. 结论可以用异体骨异位埋置预制骨皮瓣.
목적 탐토이체골이위매치예제골피판적가행성. 방법 종2010년11월지2011년7월,용엄서파마소형저위실험동물,선제작심저온냉동이체골비용；이체골경복온후치우선가천동맥공양적피판조직내,안식입부위불동분3조:피하조(A조)、심근막하조(B조)、기내조(C조),술후배양관찰.지표:이체골ECT현상(분별우술후제4주、제8주、제12주),혈관조영검사、이체골병이학검사(술후제12주). 결과 3조예제골피판술후ECT소묘현시:제8주화제12주이체골식입부위방사성교4주시증고,차이유통계학의의(P＜0.05)；혈관조영현시재피하조직、근막하조직、기육조직내적이체골균유혈관화,병여상응구역선가천동맥건립혈관련계；병리검사가견이체골재근막하조직화기육조직내혈관화작용화유도신골형성교명현. 결론 가이용이체골이위매치예제골피판.
Objective To research the feasibility of the prefabrication of skin flap with frozen allogeneic bone.Methods From November 2010 to July 2011,fifteen miniature pigs were randomly divided into three groups(n =5) according to different implanted positions.Rewarming,deep-frozen allogenic bone was implanted in subcutaneous tissue,subfascial compartment and muscle respectively.Emission Computed Tomography (ECT) was used in the 4th week,the 8th week and the 12th week postoperatively.Angiography and pathological examination was used in the 12th week.Results The difference of the result of ECT was statistically significant betweent the 4th week and the 8th week (P ＜ 0.05),and there was not statistically significant difference betweent the 12th week and the 8th week (P ＞ 0.05).Angiography showed that all allogeneic bone was vascularized in each group.Pathological examination showed that the vascularization and the inducing osteogenesis of the allogeneic bone which was implanted in the subfascial compartment or muscle was better than that in the subcutaneous tissue.Conclusion The deep-frozen allogenic bone can be used for the prefabrication of the bone-skin flap.