中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2012年
10期
874-877
,共4页
祁生贵%金新会%陈秋红%祁国荣%路霖%杨蕾
祁生貴%金新會%陳鞦紅%祁國榮%路霖%楊蕾
기생귀%금신회%진추홍%기국영%로림%양뢰
房间隔缺损%高血压,肺性%高海拔%低氧
房間隔缺損%高血壓,肺性%高海拔%低氧
방간격결손%고혈압,폐성%고해발%저양
Heart septal defect,atrial%Hypertension,pulmonary%Altitude%Anoxia
目的 了解高原地区房间隔缺损(ASD)患者合并肺动脉高压(PAH)的发生情况及PAH的危险因素.方法 回顾性分析2007年1月至2009年12月3年收治的海拔2000 m以上地区526例单纯ASD患者的临床资料.以二分类logistic回归分析ASD合并PAH的危险因素,并分析PAH与年龄和海拔高度的关系.结果 526例ASD患者中合并PAH共360例(68.4%).二分类logistic回归分析显示,ASD合并PAH的危险因素分别为缺损大小(OR:1.200,95% CI:1.156 ~ 1.246,P=0.000)、年龄(OR:1.027,95% CI:1.003 ~1.052,P=0.025)和海拔高度(OR:1.389,95% CI:1.001 ~1.637,P=0.043);性别和民族对ASD是否合并PAH无影响(P均>0.05).卡方趋势检验显示,ASD合并PAH的发生率随年龄的增长而升高(P=0.000).海拔≥3500 m地区ASD合并PAH的标准化率为74.8%,显著高于海拔2000 ~ 2499 m地区的66.2%(P=0.003)和海拔2500 ~ 3499 m地区的66.9% (P =0.005).结论 高原地区单纯ASD患者易形成PAH.ASD合并PAH的危险因素分别为缺损大小、年龄和海拔高度,性别和民族对ASD患者合并PAH无影响.
目的 瞭解高原地區房間隔缺損(ASD)患者閤併肺動脈高壓(PAH)的髮生情況及PAH的危險因素.方法 迴顧性分析2007年1月至2009年12月3年收治的海拔2000 m以上地區526例單純ASD患者的臨床資料.以二分類logistic迴歸分析ASD閤併PAH的危險因素,併分析PAH與年齡和海拔高度的關繫.結果 526例ASD患者中閤併PAH共360例(68.4%).二分類logistic迴歸分析顯示,ASD閤併PAH的危險因素分彆為缺損大小(OR:1.200,95% CI:1.156 ~ 1.246,P=0.000)、年齡(OR:1.027,95% CI:1.003 ~1.052,P=0.025)和海拔高度(OR:1.389,95% CI:1.001 ~1.637,P=0.043);性彆和民族對ASD是否閤併PAH無影響(P均>0.05).卡方趨勢檢驗顯示,ASD閤併PAH的髮生率隨年齡的增長而升高(P=0.000).海拔≥3500 m地區ASD閤併PAH的標準化率為74.8%,顯著高于海拔2000 ~ 2499 m地區的66.2%(P=0.003)和海拔2500 ~ 3499 m地區的66.9% (P =0.005).結論 高原地區單純ASD患者易形成PAH.ASD閤併PAH的危險因素分彆為缺損大小、年齡和海拔高度,性彆和民族對ASD患者閤併PAH無影響.
목적 료해고원지구방간격결손(ASD)환자합병폐동맥고압(PAH)적발생정황급PAH적위험인소.방법 회고성분석2007년1월지2009년12월3년수치적해발2000 m이상지구526례단순ASD환자적림상자료.이이분류logistic회귀분석ASD합병PAH적위험인소,병분석PAH여년령화해발고도적관계.결과 526례ASD환자중합병PAH공360례(68.4%).이분류logistic회귀분석현시,ASD합병PAH적위험인소분별위결손대소(OR:1.200,95% CI:1.156 ~ 1.246,P=0.000)、년령(OR:1.027,95% CI:1.003 ~1.052,P=0.025)화해발고도(OR:1.389,95% CI:1.001 ~1.637,P=0.043);성별화민족대ASD시부합병PAH무영향(P균>0.05).잡방추세검험현시,ASD합병PAH적발생솔수년령적증장이승고(P=0.000).해발≥3500 m지구ASD합병PAH적표준화솔위74.8%,현저고우해발2000 ~ 2499 m지구적66.2%(P=0.003)화해발2500 ~ 3499 m지구적66.9% (P =0.005).결론 고원지구단순ASD환자역형성PAH.ASD합병PAH적위험인소분별위결손대소、년령화해발고도,성별화민족대ASD환자합병PAH무영향.
Objective To analyze risk factors of pulmonary arterial hypertension(PAH) in patients with atrial septal defect (ASD) patients living at above 2000 m high altitude area.Methods We retrospectively analyzed the incidence of PAH in 526 ASD patients out of 1178 congenital heart disease patients who were hospitalized in Qinghai cardiovascular hospital between January 2007 to December 2009 and explored the risk factors including gander,age,altitude,defect size and nationalities for developing PAH in ASD patients using binary logistic regression.Results PAH prevalence was 68.4% (360/526) in ASD patients.The risk factors of developing PAH in these ASD patients were defect size(OR:1.200,95% CI:1.156-1.246,P=0.000),age(OR:1.027,95%CI:1.003-1.052,P =0.025) and altitude(OR:1.389,95% CI:1.001-1.637,P =0.043) while gender and nationality were not risk factors for PAH.The incidence of developing PAH increased with aging (P =0.000).The staudardized ratio of PAH at ≥3500 m was 74.8% which was significantly higher than that at 2000-2499 m altitude (66.2%,P =0.005) and at 2500-3499 m altitude (66.9%,P =0.005).Conclusions The risk for developing PAH is high in patients living at high altitude area.The risk factors of developing PAH in ASD patients living at high altitude are defect size,age and altitude.