国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
18期
2872-2875
,共4页
2型糖尿病%冠心病%幽门螺杆菌%相关性
2型糖尿病%冠心病%幽門螺桿菌%相關性
2형당뇨병%관심병%유문라간균%상관성
Type 2 diabetes mellitus(T2DM)%Coronary heart disease (CHD)%Helicobacter pylori (Hp)%Correlation
目的 探讨2型糖尿病(T2DM)合并冠心病(CHD)与幽门螺杆菌(Hp)感染的相关性.方法 选择临床确诊的住院和门诊T2DM患者185例,分为T2DM非合并CHD组(单纯T2DM组,109例)和T2DM合并CHD组(T2DM+CHD组,76例),检测血脂、血清Hp-IgG抗体、高敏C-反应蛋白(hs-CRP)、同型半胱氨酸(HCY)水平,进行统计学对比分析.结果 185例T2DM患者中,91例(49.19％) Hp-IgG抗体(+)显著高于对照组(30.00％)(P＜0.01),T2DM+CHD组(64.47％)显著高于单纯T2DM组(38.53％) (P＜ 0.01);Hp感染组合并CHD者(53.85％)显著高于Hp非感染组(28.72％)(P＜0.01).T2DM合并CHD与Hp感染具有显著相关性(r=0.195,t=2.690,P＜0.01).Hp感染组血清TG、TC、LDL-C、HCY和hs-CRP水平均显著高于Hp非感染组(P＜0.01),血清HDL-C水平显著低于Hp非感染组(P＜0.01).结论 T2DM合并CHD与Hp感染具有相关性,可能通过影响血脂代谢、炎性反应及HCY水平促进CHD发生发展,清除或预防Hp感染可能是防治T2DM合并CHD的策略之一.
目的 探討2型糖尿病(T2DM)閤併冠心病(CHD)與幽門螺桿菌(Hp)感染的相關性.方法 選擇臨床確診的住院和門診T2DM患者185例,分為T2DM非閤併CHD組(單純T2DM組,109例)和T2DM閤併CHD組(T2DM+CHD組,76例),檢測血脂、血清Hp-IgG抗體、高敏C-反應蛋白(hs-CRP)、同型半胱氨痠(HCY)水平,進行統計學對比分析.結果 185例T2DM患者中,91例(49.19％) Hp-IgG抗體(+)顯著高于對照組(30.00％)(P＜0.01),T2DM+CHD組(64.47％)顯著高于單純T2DM組(38.53％) (P＜ 0.01);Hp感染組閤併CHD者(53.85％)顯著高于Hp非感染組(28.72％)(P＜0.01).T2DM閤併CHD與Hp感染具有顯著相關性(r=0.195,t=2.690,P＜0.01).Hp感染組血清TG、TC、LDL-C、HCY和hs-CRP水平均顯著高于Hp非感染組(P＜0.01),血清HDL-C水平顯著低于Hp非感染組(P＜0.01).結論 T2DM閤併CHD與Hp感染具有相關性,可能通過影響血脂代謝、炎性反應及HCY水平促進CHD髮生髮展,清除或預防Hp感染可能是防治T2DM閤併CHD的策略之一.
목적 탐토2형당뇨병(T2DM)합병관심병(CHD)여유문라간균(Hp)감염적상관성.방법 선택림상학진적주원화문진T2DM환자185례,분위T2DM비합병CHD조(단순T2DM조,109례)화T2DM합병CHD조(T2DM+CHD조,76례),검측혈지、혈청Hp-IgG항체、고민C-반응단백(hs-CRP)、동형반광안산(HCY)수평,진행통계학대비분석.결과 185례T2DM환자중,91례(49.19％) Hp-IgG항체(+)현저고우대조조(30.00％)(P＜0.01),T2DM+CHD조(64.47％)현저고우단순T2DM조(38.53％) (P＜ 0.01);Hp감염조합병CHD자(53.85％)현저고우Hp비감염조(28.72％)(P＜0.01).T2DM합병CHD여Hp감염구유현저상관성(r=0.195,t=2.690,P＜0.01).Hp감염조혈청TG、TC、LDL-C、HCY화hs-CRP수평균현저고우Hp비감염조(P＜0.01),혈청HDL-C수평현저저우Hp비감염조(P＜0.01).결론 T2DM합병CHD여Hp감염구유상관성,가능통과영향혈지대사、염성반응급HCY수평촉진CHD발생발전,청제혹예방Hp감염가능시방치T2DM합병CHD적책략지일.
Objective To explore the correlation between Helicobacter pylori infection and type 2 diabetes mellitus (T2DM) complicated with coronary heart disease (CHD).Methods 185 patients diagnosed with type 2 diabetes,including inpatients and outpatients,were chosen and then divided into a T2DM group (109 cases with only T2DM) and a mixed group (76 cases with T2DM complicated with CHD).The levels of blood lipid,serum Hp-IgG antibody,High-sensitive C-reactive protein (hs-CRP),and homocysteine (HCY) in all patients were detected.The data were statistically analyzed.Results Among the 185 patients with T2DM,91(49.19％) got Hp-IgG antibody(+),which was significantly higher than the control group (30.00％) (P ＜ 0.01).More patients got Hp-IgG antibody(+) in the mixed group than in the T2DM group(64.47％ vs.38.53％,P ＜ 0.01).More patients infected by Hp complicated with CHD than patients not infected by Hp (53.85％ vs.28.72％,P ＜ 0.01).T2DM complicated with CHD positively correlated with Hp infection(r=0.195,t=2.690,P ＜ 0.01).The serum levels of TC,TG,LDL-C,HCY,and hs-CRP were markedly higher and the serum level of HDL-C was obviously lower in the patients with than without Hp infection (P ＜ 0.01).Conclusions T2DM complicated with CHD correlates with Helicobacter pylori infection.It may accelerate the generation and development of CHD affecting blood lipid metabolism,inflammatory reaction,and HCY level.Therefore,removing or preventing Hp infection might prevent and cure T2DM with CHD.
