中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2013年
2期
121-125
,共5页
刁盈盈%吕迁洲%杨昌生%魏多
刁盈盈%呂遷洲%楊昌生%魏多
조영영%려천주%양창생%위다
高血压%人软骨糖蛋白%内皮,血管
高血壓%人軟骨糖蛋白%內皮,血管
고혈압%인연골당단백%내피,혈관
Hypertension%YKL-40(human cartilage glycoprotein-39)%Endothelium,vascular
目的 探讨高血压患者血清人软骨糖蛋白(YKL-40)水平的变化及YKL-40与血管内皮功能各指标的相关性.方法 收集60例初发的原发性高血压患者(高血压组)及30例健康受试者(对照组),应用ELISA方法测定血清YKL-40浓度,并测定内皮素1(ET-1)、一氧化氮(NO)、肱动脉血流介导的血管舒张功能(FMD)以评估血管内皮功能.比较两组间血清YKL-40浓度的差异及YKL-40与内皮功能各项指标之间的相关性；按照有无合并代谢综合征(MS)将高血压组分为2组,比较两组间血清YKL-40浓度的差异.结果 高血压组血清YKL-40水平(51.7 μg/L)明显高于对照组(33.2 μg/L) (P ＜0.01).对照组、无MS高血压组、MS高血压组三组间血清YKL-40水平有显著差异(分别为33.2 μg/L、94.2 μg/L、152.3 μg/L,P＜0.05).在所有研究对象中YKL-40与收缩压、舒张压、体质指数(BMI)、甘油三酯(TG)、超敏C反应蛋白(hs-CRP)正相关(r=0.360、0.303、0.281、0.216、0.530,P＜0.05),与FMD、ET-1、NO之间无相关性.MS高血压组血清YKL-40水平(152.3μg/L)高于无MS高血压组(94.2 μg/L),差异具有显著统计学意义(P＜0.01).结论 与对照组相比,高血压组血清YKL-40水平升高且与血压水平正相关,但未见与血管内皮功能有相关性.
目的 探討高血壓患者血清人軟骨糖蛋白(YKL-40)水平的變化及YKL-40與血管內皮功能各指標的相關性.方法 收集60例初髮的原髮性高血壓患者(高血壓組)及30例健康受試者(對照組),應用ELISA方法測定血清YKL-40濃度,併測定內皮素1(ET-1)、一氧化氮(NO)、肱動脈血流介導的血管舒張功能(FMD)以評估血管內皮功能.比較兩組間血清YKL-40濃度的差異及YKL-40與內皮功能各項指標之間的相關性；按照有無閤併代謝綜閤徵(MS)將高血壓組分為2組,比較兩組間血清YKL-40濃度的差異.結果 高血壓組血清YKL-40水平(51.7 μg/L)明顯高于對照組(33.2 μg/L) (P ＜0.01).對照組、無MS高血壓組、MS高血壓組三組間血清YKL-40水平有顯著差異(分彆為33.2 μg/L、94.2 μg/L、152.3 μg/L,P＜0.05).在所有研究對象中YKL-40與收縮壓、舒張壓、體質指數(BMI)、甘油三酯(TG)、超敏C反應蛋白(hs-CRP)正相關(r=0.360、0.303、0.281、0.216、0.530,P＜0.05),與FMD、ET-1、NO之間無相關性.MS高血壓組血清YKL-40水平(152.3μg/L)高于無MS高血壓組(94.2 μg/L),差異具有顯著統計學意義(P＜0.01).結論 與對照組相比,高血壓組血清YKL-40水平升高且與血壓水平正相關,但未見與血管內皮功能有相關性.
목적 탐토고혈압환자혈청인연골당단백(YKL-40)수평적변화급YKL-40여혈관내피공능각지표적상관성.방법 수집60례초발적원발성고혈압환자(고혈압조)급30례건강수시자(대조조),응용ELISA방법측정혈청YKL-40농도,병측정내피소1(ET-1)、일양화담(NO)、굉동맥혈류개도적혈관서장공능(FMD)이평고혈관내피공능.비교량조간혈청YKL-40농도적차이급YKL-40여내피공능각항지표지간적상관성；안조유무합병대사종합정(MS)장고혈압조분위2조,비교량조간혈청YKL-40농도적차이.결과 고혈압조혈청YKL-40수평(51.7 μg/L)명현고우대조조(33.2 μg/L) (P ＜0.01).대조조、무MS고혈압조、MS고혈압조삼조간혈청YKL-40수평유현저차이(분별위33.2 μg/L、94.2 μg/L、152.3 μg/L,P＜0.05).재소유연구대상중YKL-40여수축압、서장압、체질지수(BMI)、감유삼지(TG)、초민C반응단백(hs-CRP)정상관(r=0.360、0.303、0.281、0.216、0.530,P＜0.05),여FMD、ET-1、NO지간무상관성.MS고혈압조혈청YKL-40수평(152.3μg/L)고우무MS고혈압조(94.2 μg/L),차이구유현저통계학의의(P＜0.01).결론 여대조조상비,고혈압조혈청YKL-40수평승고차여혈압수평정상관,단미견여혈관내피공능유상관성.
Objective To explore the relationship between serum YKL-40 levels and endothelial function in patients with essential hypertension (EH).Method Sixty EH patients [34 male,aged between 43-76 years,mean(59 ±7)years]and 30 healthy subjects [17 male,mean age (57 ±5) years] were enrolled in this study.Serum YKL-40 levels were measured by enzyme immunoassay (ELISA).Endothelial function [endothelin-1 (ET-1),nitric oxide (NO),flow-mediated dilatation (FMD)] was also measured.EH patients were further divided to no metabolic syndrome and metabolic syndrome group.Results Serum uric acid,ET-1,hs-CRP were significantly higher while serum NO,FMD and NMD were significantly lower in EH group than in control group (all P ＜ 0.05).YKL-40 was significantly higher in EH group than in the control group [51.7 (35.6-341.9) μg/L vs.33.2 (23.3-167.3) μg/L,P ＜ 0.05] and significantly higher in EH patients with metabolic syndrome than in EH patients without metabolic syndrome(152.3 μg/L vs.94.2 μg/L,P ＜0.05).In this cohort,serum YKL-40 level was positively correlated with SBP,DBP,BMI,TG and hsCRP(r =0.360,0.303,0.281,0.216,0.530,all P ＜ 0.05) but not correlated with FMD,ET-1 and NO (all P ＞ 0.05).Conclusions Serum YKL-40 levels are increased compared to normal controls and positively correlated with blood pressure level but not with endothelial function parameters in hypertensive patients.Serum YKL-40 level might thus be used as a biomarker reflecting inflammation status other than endothelium function in hypertensive patients.
