中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2013年
3期
219-223
,共5页
陈朔华%刘颖辉%蔡军%王爱田%马宇杰%李晓岚%高景利%赵性泉%吴寿岭
陳朔華%劉穎輝%蔡軍%王愛田%馬宇傑%李曉嵐%高景利%趙性泉%吳壽嶺
진삭화%류영휘%채군%왕애전%마우걸%리효람%고경리%조성천%오수령
血压%前瞻性研究%血压变异性
血壓%前瞻性研究%血壓變異性
혈압%전첨성연구%혈압변이성
Blood pressure%Prospective studies%Blood pressure variability
目的 探讨不同收缩压水平对年度间血压变异性(blood pressure variability,BPV)的影响.方法 此研究为前瞻性队列研究,在2006-2007年参加健康体检的101 510名开滦集团职工中每2岁为一年龄段按比例随机分层抽取5852名作为研究对象,符合入选标准(年龄≥40岁、既往无缺血性脑卒中、短暂性脑缺血发作、心肌梗死者)的5440名纳入研究队列,其中999名因任一次血压资料不完整未纳入统计分析,最终纳入统计分析的有4441名.将研究对象按平均收缩压水平分为＜120、120～、140 ～、160～、≥180 mm Hg(1 mm Hg=0.133 kPa)组,并对年度间收缩压变异性和变异系数(CV)的影响因素进行多因素线性回归分析.结果 (1)研究人群的收缩压变异性均值为10.35mm Hg,CV为7.96％;男性人群为10.54 mm Hg,CV为7.90％,女性人群为10.06 mm Hg,CV为8.04％.男性BPV水平高于女性,差异有统计学意义(P ＜0.001),男性与女性的收缩压CV比较无统计学意义.随收缩压增加BPV呈升高趋势(P ＜0.001),不同收缩压组按性别分层后,BPV仍有随血压增加而升高的趋势.(2)多因素线性回归分析结果显示,收缩压每升高20 mm Hg,BPV升高2.02mm Hg,CV升高0.388％;年龄每增加1岁,BPV增加0.044 mm Hg,CV增加0.029％;影响收缩压变异性的危险因素包括收缩压水平升高、高龄、女性和高敏C反应蛋白(hsCRP)水平.结论 收缩压水平、年龄、性别、hsCRP是影响中国北方中老年人群年度间BPV的主要因素,其中收缩压水平的影响最为显著.
目的 探討不同收縮壓水平對年度間血壓變異性(blood pressure variability,BPV)的影響.方法 此研究為前瞻性隊列研究,在2006-2007年參加健康體檢的101 510名開灤集糰職工中每2歲為一年齡段按比例隨機分層抽取5852名作為研究對象,符閤入選標準(年齡≥40歲、既往無缺血性腦卒中、短暫性腦缺血髮作、心肌梗死者)的5440名納入研究隊列,其中999名因任一次血壓資料不完整未納入統計分析,最終納入統計分析的有4441名.將研究對象按平均收縮壓水平分為＜120、120～、140 ～、160～、≥180 mm Hg(1 mm Hg=0.133 kPa)組,併對年度間收縮壓變異性和變異繫數(CV)的影響因素進行多因素線性迴歸分析.結果 (1)研究人群的收縮壓變異性均值為10.35mm Hg,CV為7.96％;男性人群為10.54 mm Hg,CV為7.90％,女性人群為10.06 mm Hg,CV為8.04％.男性BPV水平高于女性,差異有統計學意義(P ＜0.001),男性與女性的收縮壓CV比較無統計學意義.隨收縮壓增加BPV呈升高趨勢(P ＜0.001),不同收縮壓組按性彆分層後,BPV仍有隨血壓增加而升高的趨勢.(2)多因素線性迴歸分析結果顯示,收縮壓每升高20 mm Hg,BPV升高2.02mm Hg,CV升高0.388％;年齡每增加1歲,BPV增加0.044 mm Hg,CV增加0.029％;影響收縮壓變異性的危險因素包括收縮壓水平升高、高齡、女性和高敏C反應蛋白(hsCRP)水平.結論 收縮壓水平、年齡、性彆、hsCRP是影響中國北方中老年人群年度間BPV的主要因素,其中收縮壓水平的影響最為顯著.
목적 탐토불동수축압수평대년도간혈압변이성(blood pressure variability,BPV)적영향.방법 차연구위전첨성대렬연구,재2006-2007년삼가건강체검적101 510명개란집단직공중매2세위일년령단안비례수궤분층추취5852명작위연구대상,부합입선표준(년령≥40세、기왕무결혈성뇌졸중、단잠성뇌결혈발작、심기경사자)적5440명납입연구대렬,기중999명인임일차혈압자료불완정미납입통계분석,최종납입통계분석적유4441명.장연구대상안평균수축압수평분위＜120、120～、140 ～、160～、≥180 mm Hg(1 mm Hg=0.133 kPa)조,병대년도간수축압변이성화변이계수(CV)적영향인소진행다인소선성회귀분석.결과 (1)연구인군적수축압변이성균치위10.35mm Hg,CV위7.96％;남성인군위10.54 mm Hg,CV위7.90％,녀성인군위10.06 mm Hg,CV위8.04％.남성BPV수평고우녀성,차이유통계학의의(P ＜0.001),남성여녀성적수축압CV비교무통계학의의.수수축압증가BPV정승고추세(P ＜0.001),불동수축압조안성별분층후,BPV잉유수혈압증가이승고적추세.(2)다인소선성회귀분석결과현시,수축압매승고20 mm Hg,BPV승고2.02mm Hg,CV승고0.388％;년령매증가1세,BPV증가0.044 mm Hg,CV증가0.029％;영향수축압변이성적위험인소포괄수축압수평승고、고령、녀성화고민C반응단백(hsCRP)수평.결론 수축압수평、년령、성별、hsCRP시영향중국북방중노년인군년도간BPV적주요인소,기중수축압수평적영향최위현저.
Objective To observe the impact of systolic blood pressure (SBP) on visit-to-visit blood pressure variability (BPV) in middle-aged and elderly people.Methods Visit-to-visit BPV was determined in 5440 workers in the Kailuan study cohort from 2006 to 2007.The subjects were ≥40 years-old and had no history of stroke,transient ischemic attack or myocardial infarction.Participants were divided into five groups according to different levels of SBP.Linear regression was used to analyze the related factors which might affect BPV.Results Mean systolic BPV of all subjects was 10.35 mm Hg [coefficient of variation (CV 7.96％)].The mean systolic BPV of males was 10.54 mm Hg (CV 7.90％) while the mean SBPV of females was 10.06 mm Hg (CV 7.90％).The BPV of males was significant higher than that of females (P ＜ 0.001).CV of SBP was similar between males and females.Furthermore,higher SBP was associated with higher BPV.There were significant differences in BPV between different groups with different lewels of SBP (P ＜ 0.001).Linear regression analysis demonstrated that SBP,age,gender,high-sensitivity C-reactive protein (hsCRP) were affecting factors of BPV.Twenty mm Hg SBP increase was linked with 2.02 mm Hg BPV increase and 0.388％ CV increase.Age increase of 1 year was associated with 0.044 mm Hg BPV increase and 0.029％ CV increase.Conclusion SBP,age,gender and hsCRP are important factors affecting BPV in middle-aged and elderly people.Higher SBP is closely related to greater BPV in this cohort.
