中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2013年
3期
256-259
,共4页
高血压%血管内膜%颈动脉
高血壓%血管內膜%頸動脈
고혈압%혈관내막%경동맥
Hypertension%Tunica intima%Carotid arteries
目的 探讨农村社区中老年高血压患者颈动脉内膜-中膜厚度(CIMT)及斑块与血压的关联性.方法 采用区组随机抽样,对连云港赣榆县农村社区45 ～ 75岁原发性高血压患者进行流行病学调查,测量血压,彩色超声仪测定CIMT和颈动脉斑块,应用多元线性回归、logistic回归模型分析CIMT、颈动脉斑块数(或检出率)与血压之间的关系.结果 共调查524人(男242人,女282人).男性CIMT为(0.7±0.1)mm,斑块检出率46.3％,女性CIMT为(0.7 ±0.1)mm,斑块检出率34.0％.调整相关变量后,收缩压每升高l mm Hg(1 mm Hg =0.133 kPa),男性患者CIMT增加0.001 12 mm(P＜0.001),而女性患者CIMT增加不明显;与高血压1级相比,高血压3级患者中检出1个以上斑块的风险明显增大,多因素校正后增加2.136倍(OR:2.136,95％ CI:1.138 ～4.012,P=0.018).结论 在中老年高血压人群中,特别在男性患者中颈动脉CIMT与收缩压呈正比,且血压水平越高,颈动脉斑块形成风险越大;高血压是动脉粥样硬化的独立危险因子.
目的 探討農村社區中老年高血壓患者頸動脈內膜-中膜厚度(CIMT)及斑塊與血壓的關聯性.方法 採用區組隨機抽樣,對連雲港贛榆縣農村社區45 ～ 75歲原髮性高血壓患者進行流行病學調查,測量血壓,綵色超聲儀測定CIMT和頸動脈斑塊,應用多元線性迴歸、logistic迴歸模型分析CIMT、頸動脈斑塊數(或檢齣率)與血壓之間的關繫.結果 共調查524人(男242人,女282人).男性CIMT為(0.7±0.1)mm,斑塊檢齣率46.3％,女性CIMT為(0.7 ±0.1)mm,斑塊檢齣率34.0％.調整相關變量後,收縮壓每升高l mm Hg(1 mm Hg =0.133 kPa),男性患者CIMT增加0.001 12 mm(P＜0.001),而女性患者CIMT增加不明顯;與高血壓1級相比,高血壓3級患者中檢齣1箇以上斑塊的風險明顯增大,多因素校正後增加2.136倍(OR:2.136,95％ CI:1.138 ～4.012,P=0.018).結論 在中老年高血壓人群中,特彆在男性患者中頸動脈CIMT與收縮壓呈正比,且血壓水平越高,頸動脈斑塊形成風險越大;高血壓是動脈粥樣硬化的獨立危險因子.
목적 탐토농촌사구중노년고혈압환자경동맥내막-중막후도(CIMT)급반괴여혈압적관련성.방법 채용구조수궤추양,대련운항공유현농촌사구45 ～ 75세원발성고혈압환자진행류행병학조사,측량혈압,채색초성의측정CIMT화경동맥반괴,응용다원선성회귀、logistic회귀모형분석CIMT、경동맥반괴수(혹검출솔)여혈압지간적관계.결과 공조사524인(남242인,녀282인).남성CIMT위(0.7±0.1)mm,반괴검출솔46.3％,녀성CIMT위(0.7 ±0.1)mm,반괴검출솔34.0％.조정상관변량후,수축압매승고l mm Hg(1 mm Hg =0.133 kPa),남성환자CIMT증가0.001 12 mm(P＜0.001),이녀성환자CIMT증가불명현;여고혈압1급상비,고혈압3급환자중검출1개이상반괴적풍험명현증대,다인소교정후증가2.136배(OR:2.136,95％ CI:1.138 ～4.012,P=0.018).결론 재중노년고혈압인군중,특별재남성환자중경동맥CIMT여수축압정정비,차혈압수평월고,경동맥반괴형성풍험월대;고혈압시동맥죽양경화적독립위험인자.
Objective To analyze the associations of blood pressure (BP) level with carotid intimamedia thickness (CIMT) and plaque in a middle-aged and elderly hypertensive population.Methods By block randomized sampling,an epidemiological investigation was conducted among hypertensives aged 45-75 years in the northeru rural area of Jiangsu Province.Blood pressure was measured,and carotid CIMT and plaquc were determined using a coloured ultrasonograph.The relationship between blood pressure level and CIMT or plaque was analyzed using a multivariable linear regression or logistic regression model.Results A total of 524 subjects (male 242) were enrolled.CIMT and plaque prevalence were (0.7 ± 0.1) mm and 46.3％ in males and (0.7 ± 0.1)mm and 34.0％ in females.After adjustment for relevant variables,CIMT increased 0.001 12 mm with 1 mmHg systolic BP increase in males (P ＜ 0.001) but this trend was not significant in females.The risk of plaque number ＞ 1 was significantly higher in those with grade Ⅲ hypertension compared to grade I hypertensives (OR:2.136,95％ CI:1.138-4.012,P =0.018).Conclusion In this middle-aged and elderly hypertensive population,carotid CIMT is positively in relation to systolic BP,especially for male patients.Higher BP is associated with higher risk of plaque occurrence.Hypertension is thus an independent risk factor for the formation of atherosclerosis.
