中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2013年
5期
387-389
,共3页
张荣峰%夏云龙%王楚楚%高连君%尹晓盟%常栋%丛培鑫%董颖雪%张树龙
張榮峰%夏雲龍%王楚楚%高連君%尹曉盟%常棟%叢培鑫%董穎雪%張樹龍
장영봉%하운룡%왕초초%고련군%윤효맹%상동%총배흠%동영설%장수룡
心房颤动%基因%突变%导管消融术
心房顫動%基因%突變%導管消融術
심방전동%기인%돌변%도관소융술
Atrial fibrillation%Genes%Mutation%Catheter ablation
目的 报道携带基因突变的心房颤动患者3例经导管消融随访结果.方法 收集我院住院行导管消融同时证实为基因突变携带的心房颤动患者3例,并分别进行46、64和38个月的随访,观察其消融结果.结果 3例患者的突变基因为:1例位于KCNA5,2例位于NPPA.KCNA5基因突变患者为61岁男性,阵发性心房颤动20余年,行双侧环肺静脉电隔离后随访46个月未复发；2例携带NPPA基因突变的患者均为持续性心房颤动,1例在完成双侧环肺静脉电隔离后,200 J电复律,随访64个月无复发；另1例完成双侧环肺静脉电隔离+左房顶部线+左房狭部线后,300 J电复律,随访38个月无复发.结论 3例携带KCNA5和NPPA基因突变的心房颤动患者行导管消融亦具有较好的远期预后,但仍需大样本研究进一步证实.
目的 報道攜帶基因突變的心房顫動患者3例經導管消融隨訪結果.方法 收集我院住院行導管消融同時證實為基因突變攜帶的心房顫動患者3例,併分彆進行46、64和38箇月的隨訪,觀察其消融結果.結果 3例患者的突變基因為:1例位于KCNA5,2例位于NPPA.KCNA5基因突變患者為61歲男性,陣髮性心房顫動20餘年,行雙側環肺靜脈電隔離後隨訪46箇月未複髮；2例攜帶NPPA基因突變的患者均為持續性心房顫動,1例在完成雙側環肺靜脈電隔離後,200 J電複律,隨訪64箇月無複髮；另1例完成雙側環肺靜脈電隔離+左房頂部線+左房狹部線後,300 J電複律,隨訪38箇月無複髮.結論 3例攜帶KCNA5和NPPA基因突變的心房顫動患者行導管消融亦具有較好的遠期預後,但仍需大樣本研究進一步證實.
목적 보도휴대기인돌변적심방전동환자3례경도관소융수방결과.방법 수집아원주원행도관소융동시증실위기인돌변휴대적심방전동환자3례,병분별진행46、64화38개월적수방,관찰기소융결과.결과 3례환자적돌변기인위:1례위우KCNA5,2례위우NPPA.KCNA5기인돌변환자위61세남성,진발성심방전동20여년,행쌍측배폐정맥전격리후수방46개월미복발；2례휴대NPPA기인돌변적환자균위지속성심방전동,1례재완성쌍측배폐정맥전격리후,200 J전복률,수방64개월무복발；령1례완성쌍측배폐정맥전격리+좌방정부선+좌방협부선후,300 J전복률,수방38개월무복발.결론 3례휴대KCNA5화NPPA기인돌변적심방전동환자행도관소융역구유교호적원기예후,단잉수대양본연구진일보증실.
Objective The outcome of atrial fibrillation patients with genetic mutations post ablation was not well evaluated.Methods and Results Three atrial fibrillation patients with evidence of mutations in KCNA5 and NPPA post successful circumferential pulmonary vein ablation were included.Mutation in KCNA5 was found in one male patient with paroxysmal atrial fibrillation.He was free of atrial fibrillation post ablation after 46 months follow-up.Mutations in NPPA were found in two male patients with persistent atrial fibrillation and they were free from atrial fibrillation after 64 months and 38 months follow-up post circumferential pulmonary vein ablation,roof line and mitral isthmus line ablation.Conclusion Satisfactory long term results are observed in atrial fibrillation patients with KCNA5 and NPPA mutations post circumferential pulmonary vein ablation.
