CAJ | 학술논문

目的了解三峡农村地区高尿酸血症(HUA)流行现状及其影响因素.方法 2007年在宜昌市夷陵区的农村人群进行现况调查.采用标准化问卷收集居民一般人口学情况、生活方式及行为等情况,并采集空腹静脉血进行血清尿酸测定.HUA的诊断标准:男性血清尿酸≥417 μmol/L(70 mg/L),女性血清尿酸≥357μmol/L(60 mg/L).采用多元logistic回归分析影响HUA的因素.结果共调查35岁及以上居民9354名,其中19.9％ (1866/9354)为三峡大坝建设后靠移民.男性血清尿酸水平显著高于女性[(285.1±80.2)μmol/L比(210.3±65.0) μmol/L,P＜0.01]；血清尿酸水平在男、女性中均随年龄增加而增高,且在不同年龄段男性血清尿酸水平均显著高于女性(P均＞0.01).男性年龄标化HUA患病率高于女性(5.6％比3.3％,P＜0.01)；35 ～44岁、45～54岁年龄段男性HUA患病率均显著高于女性(P均＜0.01)；在55 ～ 64岁及≥65岁年龄段中,男、女性患病率差异均无统计学意义(P均＞0.05).调整年龄、性别、受教育水平、职业以及移民因素后,多元logistic 回归分析显示:与非饮酒者比较,饮酒者HUA患病风险较高(OR=2.06,95％ CI:1.59 ～2.67,P＜0.01)；与绿色蔬菜和水果摄入量较高者比较,低摄入者HUA患病风险较高(OR=1.77,95％ CI:1.27～2.47,P＜0.01).结论三峡农村地区HUA患病率较低,饮酒、低绿色蔬菜和水果摄入可能是HUA的危险因素.
목적 료해삼협농촌지구고뇨산혈증(HUA)류행현상급기영향인소.방법 2007년재의창시이릉구적농촌인군진행현황조사.채용표준화문권수집거민일반인구학정황、생활방식급행위등정황,병채집공복정맥혈진행혈청뇨산측정.HUA적진단표준:남성혈청뇨산≥417 μmol/L(70 mg/L),녀성혈청뇨산≥357μmol/L(60 mg/L).채용다원logistic회귀분석영향HUA적인소.결과 공조사35세급이상거민9354명,기중19.9％ (1866/9354)위삼협대패건설후고이민.남성혈청뇨산수평현저고우녀성[(285.1±80.2)μmol/L비(210.3±65.0) μmol/L,P＜0.01]；혈청뇨산수평재남、녀성중균수년령증가이증고,차재불동년령단남성혈청뇨산수평균현저고우녀성(P균＞0.01).남성년령표화HUA환병솔고우녀성(5.6％비3.3％,P＜0.01)；35 ～44세、45～54세년령단남성HUA환병솔균현저고우녀성(P균＜0.01)；재55 ～ 64세급≥65세년령단중,남、녀성환병솔차이균무통계학의의(P균＞0.05).조정년령、성별、수교육수평、직업이급이민인소후,다원logistic 회귀분석현시:여비음주자비교,음주자HUA환병풍험교고(OR=2.06,95％ CI:1.59 ～2.67,P＜0.01)；여록색소채화수과섭입량교고자비교,저섭입자HUA환병풍험교고(OR=1.77,95％ CI:1.27～2.47,P＜0.01).결론 삼협농촌지구HUA환병솔교저,음주、저록색소채화수과섭입가능시HUA적위험인소.
Objective To explore the epidemiological status and risk factors of hyperuricemia in rural area of the Three Gorges.Methods A cross-sectional survey was carried out in rural area of Yiling District,Yichang City,which was located north-west bank of Xiling Gorge in 2007.A standard structure questionnaire was used to collect demographic data,social-economic status and life-style features.Fasting venous blood was collected and serum uric acid (SUA) was determined.Hyperuricemia was defined as SUA levels ≥ 417 μmol/L (70 mg/L) in men and ≥ 357 μmol/L (60 mg/L) in women.Multiple logistic regression analysis was used to analysed the risk factors of hyperuricemia.Results A total of 9354 participants aged 35 and above were included,19.9％ (1866/9354) participants were the Three Gorges migrants.Serum uric acid level in men was significantly higher than that in women[(285.1 ± 80.2) μmol/L vs.(210.3-65.0)μ mol/L,P ＜ 0.01].Serum uric acid level increased significantly in both genders in proportion to increase of age,and was higher in men than in women in all age groups (all P ＜ 0.01).The age-adjusted prevalence was significantly higher in men than in women (5.6％ vs.3.3％,P ＜0.01),and was also higher in men aged 35-44 and aged 45-54 than in women (both P ＜ 0.01).There was no significance in prevalence of hyperuricemia in both men and women aged 55-64 and aged ≥ 65.After adjusting age,gender,educational level,migration and occupation,the multiple logistic regression analysis showed that the prevalence of hyperuricemia was higher in alcohol drinking participants than that of nonalcohol drinking participants (OR =2.06,95％ CI:1.59-2.67,P ＜ 0.01),and in participants used to consume less green vegetables and fruits than in participants consuming more green vegetables and fruits (OR =1.77,95％ CI:1.27-2.47,P ＜ 0.01).Conclusions The prevalence of hyperuricemia is relatively low in rural area of the Three Gorges.Alcohol drinking and low intake of green vegetables and fruits are the risk factors of hyperuricemia in this population.