CAJ | 학술논문

目的进一步了解非胃黏膜相关淋巴组织(MALT)淋巴瘤患者的临床特点并探讨合理的治疗方法.方法回顾性分析57例经病理确诊的非胃MALT淋巴瘤患者资料,对其临床特点和治疗疗效进行分析.结果 57例患者中,男32例、女25例,中位年龄58(14 ～86)岁,常见发病部位为肺及支气管(17例,29.8％)、肠道(16例,28.1％)、涎腺(8例,14.0％)、眼及附属器(7例,12.3％)等.临床分期为Ⅰ～Ⅱ期者35例(61.4％),Ⅲ～Ⅳ期者22例(38.6％),淋巴结受累者26例(45.6％),多个结外器官受累者7例(12.5％).56例接受治疗的患者完全缓解率为66.0％,总反应率85.7％.中位随访时间52个月,患者5年总生存(OS)率和5年无疾病进展生存(PFS)率分别为91.6％和77.7％.单纯手术组、单纯化疗组、手术+化疗、手术+化疗+放疗组5年OS率分别为87.5％、100.0％、90.2％和100.0％,5年PFS率分别为62.3％、80.0％、90.2％和75.0％,差异无统计学意义.单纯手术者复发率高(22.3％).结论非胃MALT淋巴瘤起病呈播散性,患者治疗反应率高,预后好,各种治疗方法的OS率差异无统计学意义,但单纯手术者复发率高.
목적 진일보료해비위점막상관림파조직(MALT)림파류환자적림상특점병탐토합리적치료방법.방법 회고성분석57례경병리학진적비위MALT림파류환자자료,대기림상특점화치료료효진행분석.결과 57례환자중,남32례、녀25례,중위년령58(14 ～86)세,상견발병부위위폐급지기관(17례,29.8％)、장도(16례,28.1％)、연선(8례,14.0％)、안급부속기(7례,12.3％)등.림상분기위Ⅰ～Ⅱ기자35례(61.4％),Ⅲ～Ⅳ기자22례(38.6％),림파결수루자26례(45.6％),다개결외기관수루자7례(12.5％).56례접수치료적환자완전완해솔위66.0％,총반응솔85.7％.중위수방시간52개월,환자5년총생존(OS)솔화5년무질병진전생존(PFS)솔분별위91.6％화77.7％.단순수술조、단순화료조、수술+화료、수술+화료+방료조5년OS솔분별위87.5％、100.0％、90.2％화100.0％,5년PFS솔분별위62.3％、80.0％、90.2％화75.0％,차이무통계학의의.단순수술자복발솔고(22.3％).결론 비위MALT림파류기병정파산성,환자치료반응솔고,예후호,각충치료방법적OS솔차이무통계학의의,단단순수술자복발솔고.
Objective To further understand the clinical features of non-gastric mucosa-associated lymphoid tissue (MALT) lymphoma and investigate its suitable treatment.Methods A retrospective survey of 57 non-gastric MATL lymphoma patients pathologically confirmed in our hospital from 1999 to 2011.Results The median age was 58 years (range 14-86 years).Common presenting sites of non-gastric MALT lymphoma included lungs and upper respiratory tract (17 patients,29.8％),intestinal tracts (16 patients,28.1％),orbital and ocular adnexal (7 patients,12.3 ％),and salivary glands (8 patients,14.0％).Stage Ⅰ-Ⅱ disease presented in 35 patients(61.4％),stage Ⅲ-Ⅳ disease in 22 patients (38.6％).A total of 26 patients had nodal involvement and 7 patients multiple organ involvement.Regimens included surgery alone,chemotherapy alone,surgery followed by chemotherapy or chemoradiotherapy.The complete response (CR) rate was 66.0％ and the overall response rate 85.7％.At a median follow-up of 52 months,the 5-year overall survival (OS) and the 5-year progression free survival (PFS) were 91.6％ and 77.7％,respectively.The 5-year survival rate of surgery,chemotherapy,surgery + chemotherapy,surgery + chemotherapy + radiotherapy groups were 87.5％,100.0％,90.2％ and 100.0％,respectively,without significant differences.The 5-year PFS of the four groups were 62.3％,80.0％,90.2％ and 75.0％ respectively.Conclusions Non-gastric MALT lymphoma is characterized by disseminated onset,favorable response to treatments and good outcomes.There is no statistically significant difference in the overall survival of the various treatments.But the recurrence rate of surgery alone is relatively high (22.3％).