中华血液学杂志
中華血液學雜誌
중화혈액학잡지
Chinese Journal of Hematology
2013年
5期
383-388
,共6页
李菲%易树华%于珍%邢立杰%徐燕%齐军元%赵耀中%李增军%邱录贵
李菲%易樹華%于珍%邢立傑%徐燕%齊軍元%趙耀中%李增軍%邱錄貴
리비%역수화%우진%형립걸%서연%제군원%조요중%리증군%구록귀
白血病,淋巴细胞,慢性,B细胞%利妥昔单抗%氟达拉滨%环磷酰胺%抗肿瘤联合化疗方案
白血病,淋巴細胞,慢性,B細胞%利妥昔單抗%氟達拉濱%環燐酰胺%抗腫瘤聯閤化療方案
백혈병,림파세포,만성,B세포%리타석단항%불체랍빈%배린선알%항종류연합화료방안
Leukemia,lymphocytic,chronic,B cell%Rituximab%Fludarabine%Cyclophosphamide%Antineoplastic combined chemotherapy protocols
目的 评价利妥昔单抗联合氟达拉滨和环磷酰胺(FCR)方案治疗慢性淋巴细胞白血病(CLL)的疗效和安全性.方法 回顾性分析2003年4月至2012年1月应用FCR方案治疗的26例CLL患者病例资料.根据患者的Rai危险度分层、β2-微球蛋白(β2-MG)、LDH、ZAP-70表达、CD38表达、细胞遗传学和免疫球蛋白重链可变区基因(IgVH)突变状态等指标进行分组,行疗效和生存分析.同时评价FCR方案的安全性.结果 26例患者完全缓解(CR) 10例(38.5%),部分缓解(PR) 10例(38.5%),总反应率(ORR) 76.9%.中位随访30(3 ~98)个月,中位无进展生存(PFS)时间42(16~68)个月,总生存(OS)时间63(41~85)个月.曾治疗疗程数<2个、2个疗程骨髓淋巴细胞比例下降≥50%、低LDH、低β2-MG和ZAP-70阴性与高CR率相关(P值分别为0.014、0.008、0.027、0.035和0.013).微小残留病(MRD)阴性、LDH正常和2个疗程骨髓淋巴细胞比例下降≥50%的患者PFS时间和OS时间明显优于相应对照组(P值均<0.05),非遗传学高危组患者PFS时间优于遗传学高危组患者(P =0.005),OS时间差异无统计学意义.FCR方案的主要不良反应为胃肠道反应(88.5%);其次为骨髓抑制(80.8%),包括中性粒细胞减少、贫血和血小板减少;感染发生率为30.8%,主要为肺部感染.结论 FCR方案是治疗CLL患者的一种有效而安全的方案.MRD阳性、LDH升高、2个疗程骨髓淋巴细胞比例下降<50%和高危遗传学异常患者应在获得治疗反应后尽快寻求更加有效的治疗方案.
目的 評價利妥昔單抗聯閤氟達拉濱和環燐酰胺(FCR)方案治療慢性淋巴細胞白血病(CLL)的療效和安全性.方法 迴顧性分析2003年4月至2012年1月應用FCR方案治療的26例CLL患者病例資料.根據患者的Rai危險度分層、β2-微毬蛋白(β2-MG)、LDH、ZAP-70錶達、CD38錶達、細胞遺傳學和免疫毬蛋白重鏈可變區基因(IgVH)突變狀態等指標進行分組,行療效和生存分析.同時評價FCR方案的安全性.結果 26例患者完全緩解(CR) 10例(38.5%),部分緩解(PR) 10例(38.5%),總反應率(ORR) 76.9%.中位隨訪30(3 ~98)箇月,中位無進展生存(PFS)時間42(16~68)箇月,總生存(OS)時間63(41~85)箇月.曾治療療程數<2箇、2箇療程骨髓淋巴細胞比例下降≥50%、低LDH、低β2-MG和ZAP-70陰性與高CR率相關(P值分彆為0.014、0.008、0.027、0.035和0.013).微小殘留病(MRD)陰性、LDH正常和2箇療程骨髓淋巴細胞比例下降≥50%的患者PFS時間和OS時間明顯優于相應對照組(P值均<0.05),非遺傳學高危組患者PFS時間優于遺傳學高危組患者(P =0.005),OS時間差異無統計學意義.FCR方案的主要不良反應為胃腸道反應(88.5%);其次為骨髓抑製(80.8%),包括中性粒細胞減少、貧血和血小闆減少;感染髮生率為30.8%,主要為肺部感染.結論 FCR方案是治療CLL患者的一種有效而安全的方案.MRD暘性、LDH升高、2箇療程骨髓淋巴細胞比例下降<50%和高危遺傳學異常患者應在穫得治療反應後儘快尋求更加有效的治療方案.
목적 평개리타석단항연합불체랍빈화배린선알(FCR)방안치료만성림파세포백혈병(CLL)적료효화안전성.방법 회고성분석2003년4월지2012년1월응용FCR방안치료적26례CLL환자병례자료.근거환자적Rai위험도분층、β2-미구단백(β2-MG)、LDH、ZAP-70표체、CD38표체、세포유전학화면역구단백중련가변구기인(IgVH)돌변상태등지표진행분조,행료효화생존분석.동시평개FCR방안적안전성.결과 26례환자완전완해(CR) 10례(38.5%),부분완해(PR) 10례(38.5%),총반응솔(ORR) 76.9%.중위수방30(3 ~98)개월,중위무진전생존(PFS)시간42(16~68)개월,총생존(OS)시간63(41~85)개월.증치료료정수<2개、2개료정골수림파세포비례하강≥50%、저LDH、저β2-MG화ZAP-70음성여고CR솔상관(P치분별위0.014、0.008、0.027、0.035화0.013).미소잔류병(MRD)음성、LDH정상화2개료정골수림파세포비례하강≥50%적환자PFS시간화OS시간명현우우상응대조조(P치균<0.05),비유전학고위조환자PFS시간우우유전학고위조환자(P =0.005),OS시간차이무통계학의의.FCR방안적주요불량반응위위장도반응(88.5%);기차위골수억제(80.8%),포괄중성립세포감소、빈혈화혈소판감소;감염발생솔위30.8%,주요위폐부감염.결론 FCR방안시치료CLL환자적일충유효이안전적방안.MRD양성、LDH승고、2개료정골수림파세포비례하강<50%화고위유전학이상환자응재획득치료반응후진쾌심구경가유효적치료방안.
Objective To evaluate the efficacy and safety of a chemoimmunotherapy regimen of rituximab,fludarabine and cyclophosphamide (FCR) for patients with chronic lymphocytic leukemia(CLL).Methods The clinical data of 26 CLL patients receiving FCR regimen in our hospital from April 2003 to January 2012 were analyzed retrospectively.Patients were grouped according to indicators including Rai risk stratification,β2-MG,LDH,ZAP-70,CD38,cytogenetics and immunoglobulin heavy chain variable region gene (IgVH) mutation status.Therapy efficacy and survival were evaluated and the safety of FCR regimen was assessed.Results Among 26 patients,the overall response rate (ORR) was 76.9%,10 patients (38.5%) achieved complete remission (CR) and 10 (38.5%) partial remission (PR).With a median follow-up time of 30(3-98) months,the median estimated progression-free survival(PFS) for all patients was 42(16-68) months and median overall survival (OS) was 63 (41-85)months.Clinical parameters associated with higher CR rates were < 2 courses of prior treatment regimens,proportions of bone marrow lymphocytes declining ≥ 50% after 2 courses of FCR,low LDH,low β2-MG and ZAP-70 negative (P =0.014,0.008,O.027,0.035 and 0.013,retrospectively).PFS and OS time in minimal residual disease (MRD)-negative,normal LDH and proportions of bone marrow lymphocytes declining ≥ 50% after 2 courses of FCR patients were significantly better than that of the control group (P < 0.05),PFS in the non-high-risk genetics group was significantly better than that in the high-risk genetics group (P =0.005),while OS between two groups showed no statistically significant difference.The most common toxicities were gastrointestinal reactions (88.5%),followed by bone marrow suppression (80.8%):including neutropenia,anemia and thrombocytopenia.Infections accounted for 30.8%,mainly lung infection.Conclusion FCR is an effective and well-tolerated therapy for patients with CLL.Patients with MRD-positive,elevated LDH,proportions of bone marrow lymphocytes declining < 50% after 2 courses of FCR and high risk genetics patients are suitable for more effective treatment after achieving treatment response.