中华血液学杂志
中華血液學雜誌
중화혈액학잡지
Chinese Journal of Hematology
2013年
9期
762-766
,共5页
内分泌%伊马替尼%白血病,髓系,慢性,BCR-ABL
內分泌%伊馬替尼%白血病,髓繫,慢性,BCR-ABL
내분비%이마체니%백혈병,수계,만성,BCR-ABL
Endocrine glands%Imatinib mesylate%Leukemia,myelogenous,chronic,BCR-ABL
目的 通过对服用伊马替尼(IM)的慢性髓性白血病(CML)患者甲状腺、性腺、肾上腺三种腺体激素水平的测定,探讨IM对患者内分泌系统的影响.方法 对69例CML患者测定86例次,测定指标包括外周静脉血三碘甲状腺氨酸总量(TT3)、甲状腺素总量(TT4)、促甲状腺激素(TSH)、睾酮、孕酮、雌二醇、晨8:00-10:00时血清总皮质醇.同时按不同用药时间、血药浓度及临床症状分组比较,分析内分泌激素水平与上述因素之间的关系.结果 在7种所测定的激素中,TSH升高者14例(20.3％),TT3降低者8例(11.6％),男性睾酮降低8例(18.6％).仅发现TT3和男性睾酮在不同用药时间组之间差异有统计学意义,这两种激素水平均随用药时间延长而下降,与用药时间呈负相关(rTT3=-0.273,P=0.010；r睾酮=-0.302,P=0.025)；7种激素水平变化与IM在患者体内的血药浓度之间无相关性.结论 部分IM服用者存在TT3降低及TSH升高,部分男性服用者存在睾酮降低的现象,并表现出相关临床症状,上述影响与用药时间相关.
目的 通過對服用伊馬替尼(IM)的慢性髓性白血病(CML)患者甲狀腺、性腺、腎上腺三種腺體激素水平的測定,探討IM對患者內分泌繫統的影響.方法 對69例CML患者測定86例次,測定指標包括外週靜脈血三碘甲狀腺氨痠總量(TT3)、甲狀腺素總量(TT4)、促甲狀腺激素(TSH)、睪酮、孕酮、雌二醇、晨8:00-10:00時血清總皮質醇.同時按不同用藥時間、血藥濃度及臨床癥狀分組比較,分析內分泌激素水平與上述因素之間的關繫.結果 在7種所測定的激素中,TSH升高者14例(20.3％),TT3降低者8例(11.6％),男性睪酮降低8例(18.6％).僅髮現TT3和男性睪酮在不同用藥時間組之間差異有統計學意義,這兩種激素水平均隨用藥時間延長而下降,與用藥時間呈負相關(rTT3=-0.273,P=0.010；r睪酮=-0.302,P=0.025)；7種激素水平變化與IM在患者體內的血藥濃度之間無相關性.結論 部分IM服用者存在TT3降低及TSH升高,部分男性服用者存在睪酮降低的現象,併錶現齣相關臨床癥狀,上述影響與用藥時間相關.
목적 통과대복용이마체니(IM)적만성수성백혈병(CML)환자갑상선、성선、신상선삼충선체격소수평적측정,탐토IM대환자내분비계통적영향.방법 대69례CML환자측정86례차,측정지표포괄외주정맥혈삼전갑상선안산총량(TT3)、갑상선소총량(TT4)、촉갑상선격소(TSH)、고동、잉동、자이순、신8:00-10:00시혈청총피질순.동시안불동용약시간、혈약농도급림상증상분조비교,분석내분비격소수평여상술인소지간적관계.결과 재7충소측정적격소중,TSH승고자14례(20.3％),TT3강저자8례(11.6％),남성고동강저8례(18.6％).부발현TT3화남성고동재불동용약시간조지간차이유통계학의의,저량충격소수평균수용약시간연장이하강,여용약시간정부상관(rTT3=-0.273,P=0.010；r고동=-0.302,P=0.025)；7충격소수평변화여IM재환자체내적혈약농도지간무상관성.결론 부분IM복용자존재TT3강저급TSH승고,부분남성복용자존재고동강저적현상,병표현출상관림상증상,상술영향여용약시간상관.
Objective To measure the levels of hormones in chronic myelogenous leukemia (CML) patients receiving imatinib mesylate (IM) and evaluate the effects of IM on endocrine system.Methods 69 patients with CML while taking IM were enrolled and a total of 86 peripheral blood samples were detected.The levels of total triiodothyronine (TT3),total tetraiodothyronine (TT4),thyroid stimulating hormone (TSH),testosterone,progesterone,estradiol (E2),plasma total cortisol (PTC) at 8:00-10:00 am measured.Concentration of hormones in different groups were measured to evaluate the effects of IM on endocrine system and relationships with its administration duration,plasma concentration and clinical symptoms.Results ①Of the 7 types of hormones,an elevation of TSH level was found in 14 patients (20.3％),a decrease of TT3 and testosterone in 8 patients (11.6％) and 8 males (18.6％),respectively.②A significant decline of TT3 and testosterone was observed in all patinets divided by different administration duration.Negative correlation was seen between TT3 level and duration of administration (r=-0.273,P=0.010),which was also found for testosterone (r=-0.302,P=0.025).③There was no correlation between serum levels of the seven hormones and concentration of IM.Conclusion IM affect the levels of thyroid and sex hormones in some patients with clinical manifestations:a decrease of TT3,testosterone and testosterone,an increase of TSH,which have relationship with the duration of administration.
