CAJ | 학술논문

目的观察采用培美曲塞治疗原发性中枢神经系统淋巴瘤(primary central nervoussystem lymphoma,PCNSL)复发患者的有效性及安全性.方法对收治的7例复发性PCNSL患者的临床资料进行回顾性分析.结果 7例患者中有3例脑内异位复发,3例脑内原位复发,1例脑脊膜转移.复发后给予大剂量培美曲塞(900 mg/m2)化疗,并补充叶酸和维生素B12,每3周给药1次.经治疗后7例患者中2例达到完全缓解,3例达到部分缓解,2例疾病进展,总有效率为71.4％.不良反应主要以骨髓抑制及胃肠道反应为主.结论 PCNSL患者复发后治疗困难,预后差,采用培美曲塞治疗是一项有意义的探索.
목적 관찰채용배미곡새치료원발성중추신경계통림파류(primary central nervoussystem lymphoma,PCNSL)복발환자적유효성급안전성.방법 대수치적7례복발성PCNSL환자적림상자료진행회고성분석.결과 7례환자중유3례뇌내이위복발,3례뇌내원위복발,1례뇌척막전이.복발후급여대제량배미곡새(900 mg/m2)화료,병보충협산화유생소B12,매3주급약1차.경치료후7례환자중2례체도완전완해,3례체도부분완해,2례질병진전,총유효솔위71.4％.불량반응주요이골수억제급위장도반응위주.결론 PCNSL환자복발후치료곤난,예후차,채용배미곡새치료시일항유의의적탐색.
Objective To explore the efficacy and safety of pemetrexed in the treatment of relapsed primary central nervous system lymphoma (PCNSL).Methods Seven cases with relapsed PCNSL admitted in our hospital between August 2012 and August 2013 were retrospectively reviewed.Results Of the 7 relapsed cases,ectopic recurrence occurred in 3,in situ recurrence in 3 and leptomeningeal metastasis in 1.Patients with relapsed PCNSL were administered with high-dose pemetrexed (900 mg/m2) once for every 3 weeks and supplemented with folic acid and vitamin B12.Complete remission was obtained in 2 patients,partial remission in 3 patient and progressive disease in 2.The overall response rate was 71.4％ (5/7).The main adverse reactions were myelosuppression and gastrointestinal reaction.Conclusions Treatment of relapsed PCNSL is difficult,and its prognosis is very poor.Pemetrexed therapy is a meaningful trial.