CAJ | 학술논문

目的探讨收缩压(SBP)、LDL-C对颈动脉斑块的影响.方法在参加2006-2009年健康体检的101 510名某公司在职及离退休职工中,按年龄、性别比例分层随机抽取5852名作为观察队列,于2010-2011年对观察队列进行健康体检,同时进行了颈动脉超声检查,最后符合入选标准和资料完整的为5361名,将其分为SBP及LDL-C正常(3524名)、SBP正常但LDL-C升高(356名)、SBP升高但LDL-C正常(1308名)、SBP及LDL-C升高(173名)共4组.计算各组颈动脉斑块的检出率及加权率,并采用logistic回归分析SBP及LDL-C水平对颈动脉斑块检出率的影响.结果 SBP及LDL-C正常、SBP正常但LDL-C升高、SBP升高但LDL-C正常、SBP及LDL-C升高组颈动脉斑块检出率分别为33.7％ (1186/3524)、41.3％ (147/356)、64.8％(847/1308)、68.8％(119/173)(x=425.75,P＜0.05),加权检出率分别为36.0％、42.0％、64.5％、68 3％；男性颈动脉斑块的检出率分别为44.2％ (877/1985)、51.1％(97/190)、70.6％(657/930)、71.3％(82/115)(x2=194.02,P＜0.05),加权率分别为31.2％、36.1％、49.8％、50.3％；女性分别为20.1％ (309/1539)、30.1％ (50/166)、50.3％(190/378)、63.8％(37/58)(x2=180.17,P ＜0.05),加权检出率分别为30.9％、46.3％、70.3％、88.1％,校正其他因素后,与SBP及LDL-C正常组相比,SBP正常LDL-C升高、SBP升高LDL-C正常、SBP及LDL-C升高组的OR (95％CI)值分别为1.37 (1.05～1.78),2.05(1.74～2.43),2.12(1.45～3.12).结论高SBP与高LDL-C是颈动脉斑块形成的危险因素,与高LDL-C相比,高SBP引起颈动脉斑块的风险更大.
목적 탐토수축압(SBP)、LDL-C대경동맥반괴적영향.방법 재삼가2006-2009년건강체검적101 510명모공사재직급리퇴휴직공중,안년령、성별비례분층수궤추취5852명작위관찰대렬,우2010-2011년대관찰대렬진행건강체검,동시진행료경동맥초성검사,최후부합입선표준화자료완정적위5361명,장기분위SBP급LDL-C정상(3524명)、SBP정상단LDL-C승고(356명)、SBP승고단LDL-C정상(1308명)、SBP급LDL-C승고(173명)공4조.계산각조경동맥반괴적검출솔급가권솔,병채용logistic회귀분석SBP급LDL-C수평대경동맥반괴검출솔적영향.결과 SBP급LDL-C정상、SBP정상단LDL-C승고、SBP승고단LDL-C정상、SBP급LDL-C승고조경동맥반괴검출솔분별위33.7％ (1186/3524)、41.3％ (147/356)、64.8％(847/1308)、68.8％(119/173)(x=425.75,P＜0.05),가권검출솔분별위36.0％、42.0％、64.5％、68 3％；남성경동맥반괴적검출솔분별위44.2％ (877/1985)、51.1％(97/190)、70.6％(657/930)、71.3％(82/115)(x2=194.02,P＜0.05),가권솔분별위31.2％、36.1％、49.8％、50.3％；녀성분별위20.1％ (309/1539)、30.1％ (50/166)、50.3％(190/378)、63.8％(37/58)(x2=180.17,P ＜0.05),가권검출솔분별위30.9％、46.3％、70.3％、88.1％,교정기타인소후,여SBP급LDL-C정상조상비,SBP정상LDL-C승고、SBP승고LDL-C정상、SBP급LDL-C승고조적OR (95％CI)치분별위1.37 (1.05～1.78),2.05(1.74～2.43),2.12(1.45～3.12).결론 고SBP여고LDL-C시경동맥반괴형성적위험인소,여고LDL-C상비,고SBP인기경동맥반괴적풍험경대.
Objective To explore the different effects of systolic blood pressure(SBP) and low density lipoprotein on carotid plaques(LDL-C).Methods A total of 101 510 serving and retired workers of a company who participated in the health examination in 2006-2009,5852 participants were selected as study subjects by stratified random sampling according to the age and sex ratio.These subjects took their health examination in 2010-2011 including the carotid ultrasound.Finally,5361 eligible participants with complete data were included in the analysis.The detection and weighted rates of carotid plaques were calculated for four groups:normal SBP and LDL-C group (3524 subjects),normal SBP and high LDL-C group (356 subjects),elevated SBP and normal LDL-C group (1308 subjects) and elevated SBP and high LDL-C group (173 subjects).The effects of different baseline SBP and LDL-C on detection rates of the carotid artery plaques were analyzed by logistic regression.Results The detection rate of carotid plaques in normal SBP and LDL-C group,normal SBP and high LDL-C group,elevated SBP and normal LDL-C group,elevated SBP and high LDL-C group was 33.7％ (1186/3524),41.3％ (147/356),64.8％ (847/1308),68.8％ (119/173) (x2 =425.75,P ＜ 0.05) and the weighted detection rate was 36.0％,42.0％,64.5％and 68.3 ％ respectively.For men,the detection rate was 44.2％ (877/1985),51.1％ (97/190),70.6％(657/930),71.3％ (82/1 15) (x2 =194.02,P ＜ 0.05) and the weighted detection rate was 31.2％,36.1％,49.8％ and 50.3％ respectively.For women,the detection rate was 20.1％ (309/1539),30.1％(50/166),50.3％ (190/378),63.8％ (37/58) (x2 =180.17,P ＜ 0.05) and the weighted detection rate was 30.9％,46.3％,70.3％,and 88.1％ respectively.After adjusted for other risk factors,the OR (95 ％ CI) value was 1.37 (1.05-1.78),2.05 (1.74-2.43) and 2.12 (1.45-3.12) for normal SBP and high LDL-C group,elevated SBP and normal LDL-C group and elevated SBP and high LDL-C group respectively compared with normal SBP and LDL-C group.Conclusion Elevated SBP and high LDL-C were risk factors of the carotid artery plaques.Compared with high LDL-C,elevated SBP may add a higher risk for carotid plaques.