中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2013年
4期
358-362
,共5页
张琪%钱云%靳子义%董美华%韩仁强%周金意%赵金扣%张作风%武鸣
張琪%錢雲%靳子義%董美華%韓仁彊%週金意%趙金釦%張作風%武鳴
장기%전운%근자의%동미화%한인강%주금의%조금구%장작풍%무명
超重%肥胖症%中国%乳腺肿瘤%Meta分析
超重%肥胖癥%中國%乳腺腫瘤%Meta分析
초중%비반증%중국%유선종류%Meta분석
Overweight%Obesity%China%Breast neoplasms%Meta-analysis
目的 探讨超重肥胖与中国女性乳腺癌发病风险的关系.方法 收集国内外公开发表的关于超重肥胖与中国女性乳腺癌研究的文献,以“乳腺癌”、“超重”、“肥胖”、“体重”、“体质指数”、“体重指数”和“危险因素”为关键词,检索中国知网、万方数据知识服务平台、中文期刊数据库(维普)等中文数据库；以“breast cancer”、“overweight”、“obesity”、“China”、“risk factors”为关键词,检索荷兰医学文摘(Embase)、PubMed、Science Direct、Elsevier、Cochrane等英文数据库并辅以文献追溯等方法,时间范围从各数据库建库至2012年4月,共检索到124篇文献.、采用Stata11.2软件进行统计分析,运用Meta分析的方法计算合并OR(95％ CI)值.结果 最终纳入18篇文献,包括中文12篇,英文6篇,纳入研究的病例7217例,对照81 605名.Meta分析的结果表明合并OR(95％CI)值为1.08 (1.04～1.12),超重肥胖女性相对正常女性乳腺癌的发病风险增加了7.7％,绝经状态调整前后超重肥胖女性相对于正常BMI值女性的OR(95％ CI)值分别为1.07 (1.03～ 1.11)和1.56 (1.29～1.84).结论 超重肥胖是中国女性乳腺癌的重要危险因素之一,有针对性的开展干预将有助于降低女性乳腺癌的人群发病风险.
目的 探討超重肥胖與中國女性乳腺癌髮病風險的關繫.方法 收集國內外公開髮錶的關于超重肥胖與中國女性乳腺癌研究的文獻,以“乳腺癌”、“超重”、“肥胖”、“體重”、“體質指數”、“體重指數”和“危險因素”為關鍵詞,檢索中國知網、萬方數據知識服務平檯、中文期刊數據庫(維普)等中文數據庫；以“breast cancer”、“overweight”、“obesity”、“China”、“risk factors”為關鍵詞,檢索荷蘭醫學文摘(Embase)、PubMed、Science Direct、Elsevier、Cochrane等英文數據庫併輔以文獻追溯等方法,時間範圍從各數據庫建庫至2012年4月,共檢索到124篇文獻.、採用Stata11.2軟件進行統計分析,運用Meta分析的方法計算閤併OR(95％ CI)值.結果 最終納入18篇文獻,包括中文12篇,英文6篇,納入研究的病例7217例,對照81 605名.Meta分析的結果錶明閤併OR(95％CI)值為1.08 (1.04～1.12),超重肥胖女性相對正常女性乳腺癌的髮病風險增加瞭7.7％,絕經狀態調整前後超重肥胖女性相對于正常BMI值女性的OR(95％ CI)值分彆為1.07 (1.03～ 1.11)和1.56 (1.29～1.84).結論 超重肥胖是中國女性乳腺癌的重要危險因素之一,有針對性的開展榦預將有助于降低女性乳腺癌的人群髮病風險.
목적 탐토초중비반여중국녀성유선암발병풍험적관계.방법 수집국내외공개발표적관우초중비반여중국녀성유선암연구적문헌,이“유선암”、“초중”、“비반”、“체중”、“체질지수”、“체중지수”화“위험인소”위관건사,검색중국지망、만방수거지식복무평태、중문기간수거고(유보)등중문수거고；이“breast cancer”、“overweight”、“obesity”、“China”、“risk factors”위관건사,검색하란의학문적(Embase)、PubMed、Science Direct、Elsevier、Cochrane등영문수거고병보이문헌추소등방법,시간범위종각수거고건고지2012년4월,공검색도124편문헌.、채용Stata11.2연건진행통계분석,운용Meta분석적방법계산합병OR(95％ CI)치.결과 최종납입18편문헌,포괄중문12편,영문6편,납입연구적병례7217례,대조81 605명.Meta분석적결과표명합병OR(95％CI)치위1.08 (1.04～1.12),초중비반녀성상대정상녀성유선암적발병풍험증가료7.7％,절경상태조정전후초중비반녀성상대우정상BMI치녀성적OR(95％ CI)치분별위1.07 (1.03～ 1.11)화1.56 (1.29～1.84).결론 초중비반시중국녀성유선암적중요위험인소지일,유침대성적개전간예장유조우강저녀성유선암적인군발병풍험.
Objective To estimate the association between overweight,obesity and the risk of breast cancer in Chinese female population.Methods Literatures published in China and abroad about overweight,obesity and breast cancer risk among Chinese females were searched.We used "breast cancer","overweight"," obesity"," weight"," body mass index" and "risk factors" as keywords,to retrieve papers in Chinese literature databases including CNKI,Wanfang and Weipu database.The same strategy was used to retrieve English papers in English literature database including Embase database,PubMed,Science Direct,Elsevier and Cochrane database,supplemented by literature tracing method.Time range was from the founding of each database to April 2012.A total of 124 research papers were collected.Using Stata11.2 software,meta-analysis was conducted,combined odds ratio (OR) and 95％ confidence interval (CI) were calculated to estimate the associations between overweight,obesity and the risk of breast cancer in Chinese female population.Results Eighteen studies were included in meta-analysis,among them 12 studies were in Chinese and 6 were in English,with a number of 7217 cases and 81 605 controls.Results showed a 7.7％increased risk of breast cancer among overweight or obesity women (OR =1.08,95％ CI:1.04-1.12).Compared with normal BMI women,the OR(95％ CI) of overweight or obesity women were 1.07 (1.03-1.11) and 1.56 (1.29-1.84) before and after the adjustment of menopausal status.Conclusion Overweight,obesity may be important risk factors of breast cancer in Chinese female population.The intervention and control activities may reduce the risk of breast cancer at population level.
