CAJ | 학술논문

目的调查北京地区居民母乳中多氯代苯并二噁英和多氯代苯并呋喃(PCDD/Fs)和二噁英样多氯联苯(dl-PCBs)的污染水平,评价一般人群PCDD/Fs和dl-PCBs的机体负荷状况.方法 2007年在北京市11个区、县中采集母乳样品110份,制成11个混合样品后,采用同位素稀释技术以高分辨气相色谱-高分辨质谱(HRGC-HRMS)测定母乳样品中的PCDD/Fs和dl-PCBs.结果北京市母乳样品中二噁英类化合物含量最高的组分为八氯代二苯并二噁英(OCDD)和多氯联苯(PCB)-118、PCB-105,其含量中位数分别为20.6 pg/g脂肪、4.07和1.63 ng/g脂肪.按毒性当量(TEQ)计,北京市11个母乳混合样品中总二噁英类化合物含量中位数为7.4 pg TEQ/g脂肪；最高的为通州区,含量中位数为13.5 pg TEQ/g脂肪；最低的为平谷区,为4.3 pg TEQ/g脂肪.结论目前北京市母乳中PCDD/Fs和dl-PCBs处于较低水平,但随着我国的快速工业化,人群此类物质的机体负荷水平有可能会上升,因此有必要持续跟踪监测.
목적 조사북경지구거민모유중다록대분병이오영화다록대분병부남(PCDD/Fs)화이오영양다록련분(dl-PCBs)적오염수평,평개일반인군PCDD/Fs화dl-PCBs적궤체부하상황.방법 2007년재북경시11개구、현중채집모유양품110빈,제성11개혼합양품후,채용동위소희석기술이고분변기상색보-고분변질보(HRGC-HRMS)측정모유양품중적PCDD/Fs화dl-PCBs.결과 북경시모유양품중이오영류화합물함량최고적조분위팔록대이분병이오영(OCDD)화다록련분(PCB)-118、PCB-105,기함량중위수분별위20.6 pg/g지방、4.07화1.63 ng/g지방.안독성당량(TEQ)계,북경시11개모유혼합양품중총이오영류화합물함량중위수위7.4 pg TEQ/g지방；최고적위통주구,함량중위수위13.5 pg TEQ/g지방；최저적위평곡구,위4.3 pg TEQ/g지방.결론 목전북경시모유중PCDD/Fs화dl-PCBs처우교저수평,단수착아국적쾌속공업화,인군차류물질적궤체부하수평유가능회상승,인차유필요지속근종감측.
Objective To investigate contamination levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in human breast milk from Beijing residents,and evaluate the human body burden of PCDD/Fs and dl-PCBs of general population.Methods A total of 110 human milk samples were collected from 11 regions in Beijing in 2007.Mter 11 pooled samples were made,concentrations of PCDD/Fs and dl-PCBs in breast milk pooled samples were measured by a high resolution gas chromatography-high resolution mass spectrometry (HRCG-HRMS) with isotope dilution.Results For congeners of PCDD/Fs and dl-PCBs in human breast milk from Beijing,the highest content of congeners was octachlorodibenzo-p-dioxin (OCDD),polychlorinated biphenyl (PCB)-118,and PCB-105 with the median of 20.6 pg/g fat,4.07 ng/g fat and 1.63 ng/g fat,respectively.The concentration median of total dioxins in 11 pooled human milk samples from Beijing was 7.4 pg TEQ/g fat.The highest was 13.5 pg TEQ/g fat from Tongzhou,and the lowest was 4.3 pg TEQ/g fat from Pinggu.Conclusion The contamination level of PCDD/Fs and dl-PCBs in human milk from Beijing is relatively low.However,with the rapid industrialization in China,the human body burden of PCDD/Fs and dl-PCBs will be likely to rise.Thus,further studies should be conducted to continuously monitor the trend of contamination level.