中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2013年
6期
538-541
,共4页
林玉娣%钱云%董美华%陆凤%沈冲%靳光付%胡志斌%沈洪兵
林玉娣%錢雲%董美華%陸鳳%瀋遲%靳光付%鬍誌斌%瀋洪兵
림옥제%전운%동미화%륙봉%침충%근광부%호지빈%침홍병
全基因组关联研究%多态性,单核苷酸%糖尿病,2型%KCNQ1基因
全基因組關聯研究%多態性,單覈苷痠%糖尿病,2型%KCNQ1基因
전기인조관련연구%다태성,단핵감산%당뇨병,2형%KCNQ1기인
Genome-wide association study%Polymorphism,single nucleotide%Diabetes mellitus,type 2%KCNQ1 gene
目的 探讨江苏省居民电压依赖钾通道蛋白1(KCNQ1)基因多态性与2型糖尿病发病的关系.方法 研究对象分别来自于江苏省无锡市2007年2型糖尿病队列研究和南通市2009年慢性非传染性疾病横断面调查,共有病例2925例和对照3281名,对其进行流行病学问卷调查及体格检查,并于清晨采集空腹10 h静脉血5 ml,应用TaqMan OpenArray基因分型系统和i-PLEX SequenomMassARRAY基因分型平台进行KCNQ1基因分型.分析调整年龄、性别和BMI后KCNQ1基因4个位点多态性与2型糖尿病发病风险的关系.结果 调整年龄、性别和BMI后,KCNQ1基因rs2237897、rs2237892、rs2237895位点C等位基因的存在均增加了2型糖尿病的患病风险,相加模型的0R(95％ CI)值分别为1.41(1.30～1.54)、1.35(1.24 ～ 1.47)和1.22(1.12～1.33)(P值均＜0.05).按年龄、性别、BMI进行分层后,各层间rs2237897位点C等位基因增加了2型糖尿病的患病风险,≤56和＞56岁相加模型的0R(95％ CI)值分别为1.39(1.22～1.59)、1.43(1.28～1.60)；女性和男性的0R(95％CI)值分别为1.40(1.26～ 1.55)、1.44(1.26～1.66)；BMI＜ 24 kg/m2和≥24 kg/m2的OR(95％ CI)值分别为1.48(1.33 ～1.66)、1.34(1.17 ～1.53)(P值均＜0.05).结论 KCNQ1基因rs2237897、rs2237892、rs2237895位点多态性与江苏省汉族居民2型糖尿病的发生相关.
目的 探討江囌省居民電壓依賴鉀通道蛋白1(KCNQ1)基因多態性與2型糖尿病髮病的關繫.方法 研究對象分彆來自于江囌省無錫市2007年2型糖尿病隊列研究和南通市2009年慢性非傳染性疾病橫斷麵調查,共有病例2925例和對照3281名,對其進行流行病學問捲調查及體格檢查,併于清晨採集空腹10 h靜脈血5 ml,應用TaqMan OpenArray基因分型繫統和i-PLEX SequenomMassARRAY基因分型平檯進行KCNQ1基因分型.分析調整年齡、性彆和BMI後KCNQ1基因4箇位點多態性與2型糖尿病髮病風險的關繫.結果 調整年齡、性彆和BMI後,KCNQ1基因rs2237897、rs2237892、rs2237895位點C等位基因的存在均增加瞭2型糖尿病的患病風險,相加模型的0R(95％ CI)值分彆為1.41(1.30～1.54)、1.35(1.24 ～ 1.47)和1.22(1.12～1.33)(P值均＜0.05).按年齡、性彆、BMI進行分層後,各層間rs2237897位點C等位基因增加瞭2型糖尿病的患病風險,≤56和＞56歲相加模型的0R(95％ CI)值分彆為1.39(1.22～1.59)、1.43(1.28～1.60)；女性和男性的0R(95％CI)值分彆為1.40(1.26～ 1.55)、1.44(1.26～1.66)；BMI＜ 24 kg/m2和≥24 kg/m2的OR(95％ CI)值分彆為1.48(1.33 ～1.66)、1.34(1.17 ～1.53)(P值均＜0.05).結論 KCNQ1基因rs2237897、rs2237892、rs2237895位點多態性與江囌省漢族居民2型糖尿病的髮生相關.
목적 탐토강소성거민전압의뢰갑통도단백1(KCNQ1)기인다태성여2형당뇨병발병적관계.방법 연구대상분별래자우강소성무석시2007년2형당뇨병대렬연구화남통시2009년만성비전염성질병횡단면조사,공유병례2925례화대조3281명,대기진행류행병학문권조사급체격검사,병우청신채집공복10 h정맥혈5 ml,응용TaqMan OpenArray기인분형계통화i-PLEX SequenomMassARRAY기인분형평태진행KCNQ1기인분형.분석조정년령、성별화BMI후KCNQ1기인4개위점다태성여2형당뇨병발병풍험적관계.결과 조정년령、성별화BMI후,KCNQ1기인rs2237897、rs2237892、rs2237895위점C등위기인적존재균증가료2형당뇨병적환병풍험,상가모형적0R(95％ CI)치분별위1.41(1.30～1.54)、1.35(1.24 ～ 1.47)화1.22(1.12～1.33)(P치균＜0.05).안년령、성별、BMI진행분층후,각층간rs2237897위점C등위기인증가료2형당뇨병적환병풍험,≤56화＞56세상가모형적0R(95％ CI)치분별위1.39(1.22～1.59)、1.43(1.28～1.60)；녀성화남성적0R(95％CI)치분별위1.40(1.26～ 1.55)、1.44(1.26～1.66)；BMI＜ 24 kg/m2화≥24 kg/m2적OR(95％ CI)치분별위1.48(1.33 ～1.66)、1.34(1.17 ～1.53)(P치균＜0.05).결론 KCNQ1기인rs2237897、rs2237892、rs2237895위점다태성여강소성한족거민2형당뇨병적발생상관.
Objective To study the association of polymorphisms in the potassium voltage-gated channel,KQT-like subfamily,member 1 (KCNQ1) gene with type 2 diabetes in Chinese population from Jiangsu province.Methods Subjects consisting of 2925 cases and 3281 controls were enrolled from a community based cohort study of type 2 diabetes in Wuxi in 2007 and a community based cross-sectional survey on chronic non-communicable disease in Nantong in 2009.Epidemiological questionnaire survey and physical examinations were conducted and 10 h overnight fasting blood samples of 5 ml were drawn for all subjects.Genotypes were determined by TaqMan OpenArray Genotyping System and i-PLEX Sequenom MassARRAY platform.The relationship between KCNQ1 gene polymorphism and risk of type 2 diabetes after adjustment for age,sex and body mass index (BMI) was analyzed.Results The C allele of rs2237897,rs2237892 and rs2237895 at KCNQ1 increased the risk of type 2 diabetes with adjusted OR (95％ CI) value being 1.41 (1.30-1.54),1.35 (1.24-1.47),1.22 (1.12-1.33) respectively (all P value ＜ 0.05) under the additive genetic model after adjusted by age,sex and BMI.Stratification analyses in additive genetic model showed that the C allele of rs2237897 increased the risk of type 2 diabetes in subgroups stratified by age (≤56 years and ＞56 years),sex (females and males),BMI (＜ 24 kg/m2 and ≥ 24 kg/m2) with OR (95％ CI) value being 1.39 (1.22-1.59),1.43 (1.28-1.60),1.40 (1.26-1.55),1.44(1.26-1.66),1.48 (1.33-1.66),1.34 (1.17-1.53) respectively (all P value ＜ 0.05).Conclusion Polymorphisms of rs2237897,rs2237892 and rs2237895 in the KCNQ1 gene were associated with occurrence of type 2 diabetes among Jiangsu province population.
