中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2013年
6期
569-572
,共4页
农药%毒理学%抗蚜威%毒理学关注阈值%风险评估%Cramer分类方法
農藥%毒理學%抗蚜威%毒理學關註閾值%風險評估%Cramer分類方法
농약%독이학%항아위%독이학관주역치%풍험평고%Cramer분류방법
Pesticides%Toxicology%Pirimicarb%Threshold of toxicological concern%Risk assessment%Cramer classification
目的 以氨基甲酸酯类农药抗蚜威为模式化学物,建立可用于农药活性成分转化产物的慢性膳食暴露评估方法.方法 建立基于Cramer结构分类的毒理学关注阈值(TTC)决策树方法,利用Lazar软件对7种抗蚜威活性成分转化产物(R34836、R34885、R35140、R31805、R34865、R16210和R16192)的遗传毒性进行预测.利用2002年中国居民营养与健康状况调查数据和2011年全国污染物监测网中抗蚜威活性成分残留的监测数据,估计我国全人群以及不同年龄组人群抗蚜威活性成分转化产物的慢性膳食暴露,并按照TTC决策树方法对其进行风险评估.结果 在抗蚜威活性成分转化产物的慢性膳食暴露中,2～6岁年龄段的均值和高端(第97.5百分位数,P97.5)暴露量均最高,7种转化产物即R34836、R34885、R35140、R31805、R34865、R16210和R16192的平均暴露量分别为0.0290、0.0207、0.0015、0.0320、0.0005、0.6918和0.1274 μg/kg,高端暴露量分别为0.0817、0.0581、0.0042、0.0900、0.0014、1.9459和0.3585 μg/kg.其中又以转化产物R16210的慢性暴露最大,分别为0.6918、1.9459μg/kg,分别占TTC阈值的46.12％和129.73％.结论 TTC决策树方法是一种有效的风险评估工具,可用于农药活性成分转化产物的优先筛选和初步评估.
目的 以氨基甲痠酯類農藥抗蚜威為模式化學物,建立可用于農藥活性成分轉化產物的慢性膳食暴露評估方法.方法 建立基于Cramer結構分類的毒理學關註閾值(TTC)決策樹方法,利用Lazar軟件對7種抗蚜威活性成分轉化產物(R34836、R34885、R35140、R31805、R34865、R16210和R16192)的遺傳毒性進行預測.利用2002年中國居民營養與健康狀況調查數據和2011年全國汙染物鑑測網中抗蚜威活性成分殘留的鑑測數據,估計我國全人群以及不同年齡組人群抗蚜威活性成分轉化產物的慢性膳食暴露,併按照TTC決策樹方法對其進行風險評估.結果 在抗蚜威活性成分轉化產物的慢性膳食暴露中,2～6歲年齡段的均值和高耑(第97.5百分位數,P97.5)暴露量均最高,7種轉化產物即R34836、R34885、R35140、R31805、R34865、R16210和R16192的平均暴露量分彆為0.0290、0.0207、0.0015、0.0320、0.0005、0.6918和0.1274 μg/kg,高耑暴露量分彆為0.0817、0.0581、0.0042、0.0900、0.0014、1.9459和0.3585 μg/kg.其中又以轉化產物R16210的慢性暴露最大,分彆為0.6918、1.9459μg/kg,分彆佔TTC閾值的46.12％和129.73％.結論 TTC決策樹方法是一種有效的風險評估工具,可用于農藥活性成分轉化產物的優先篩選和初步評估.
목적 이안기갑산지류농약항아위위모식화학물,건립가용우농약활성성분전화산물적만성선식폭로평고방법.방법 건립기우Cramer결구분류적독이학관주역치(TTC)결책수방법,이용Lazar연건대7충항아위활성성분전화산물(R34836、R34885、R35140、R31805、R34865、R16210화R16192)적유전독성진행예측.이용2002년중국거민영양여건강상황조사수거화2011년전국오염물감측망중항아위활성성분잔류적감측수거,고계아국전인군이급불동년령조인군항아위활성성분전화산물적만성선식폭로,병안조TTC결책수방법대기진행풍험평고.결과 재항아위활성성분전화산물적만성선식폭로중,2～6세년령단적균치화고단(제97.5백분위수,P97.5)폭로량균최고,7충전화산물즉R34836、R34885、R35140、R31805、R34865、R16210화R16192적평균폭로량분별위0.0290、0.0207、0.0015、0.0320、0.0005、0.6918화0.1274 μg/kg,고단폭로량분별위0.0817、0.0581、0.0042、0.0900、0.0014、1.9459화0.3585 μg/kg.기중우이전화산물R16210적만성폭로최대,분별위0.6918、1.9459μg/kg,분별점TTC역치적46.12％화129.73％.결론 TTC결책수방법시일충유효적풍험평고공구,가용우농약활성성분전화산물적우선사선화초보평고.
Objective To establish the threshold of toxicological concern (TTC) approach and to apply it in the risk assessment of metabolites,degradation and reaction products of pirimicarb.Methods TTC decision tree approach based on Cramer classification was established and Lazar software was used to predict the genotoxicity of the seven transformation products of pirimicarb,namely,R34836,R34885,R35140,R31805,R34865,R16210 and R16192.Dietary exposure in general population as well as in six age population groups was estimated by using data from the Chinese National Nutrition and Health Survey and pirimicarb residue data from national chemical surveillance data in 2011.TTC decision tree approach was used for risk assessment and the exposure was compared with the corresponding TTC values.Results Of the seven transformations of pirimicarb active substance,namely,R34836,R34885,R35140,R31805,R34865,R16210 and R16192,the maximum dietary exposure of mean and large portion(P97.5) were all belong to 2-6 age group.The mean exposures of the seven transformation products for 2-6 age group,were 0.0290,0.0207,0.0015,0.0320,0.0005,0.6918 and 0.1274 μg/kg,respectively,and the corresponding P97.5 exposures were 0.0817,0.0581,0.0042,0.0900,0.0014,1.9459 and 0.3585 μg/kg.Besides,the mean and P97.5 exposure of R16210 for 2-6 age group was the largest,which were 0.6918 and 1.9459 μg/kg,accouting for 46.12％ and 129.73％ of the TTC threshold,respectively.Conclusion TTC decision tree approach is a useful tool for prior screening and primary risk assessment of the transformation products of pesticide active substance.
