中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2013年
10期
916-919
,共4页
李娟%卢莉%陈萌%黄芳%曾阳%李晓梅%马蕊%潘静彬%孙穆
李娟%盧莉%陳萌%黃芳%曾暘%李曉梅%馬蕊%潘靜彬%孫穆
리연%로리%진맹%황방%증양%리효매%마예%반정빈%손목
麻疹%抗体%疫苗%免疫
痳疹%抗體%疫苗%免疫
마진%항체%역묘%면역
Measles%Antibodies%Vaccines%Immunity
目的 了解北京市常住人口麻疹抗体水平.方法 2012年在北京市城区和郊区选择连续居住6个月以上的10个年龄组人群作为调查对象,共2125名.采用调查问卷收集调查对象的人口学特征、麻疹患病史、含麻疹成分疫苗免疫史,并采集静脉血5 ml.使用ELISA检测研究对象麻疹IgG抗体水平.结果 调查对象麻疹抗体阳性率为84.71%(1800/2125),标化阳性率为88.07%,抗体水平中位数为960.46 IU/L.不同年龄组人群中,麻疹抗体阳性率和抗体水平差异均具有统计学意义(x2 =341.60,P<0.01;H=216.27,P <0.01),其中,1岁以下婴儿最低,抗体阳性率和抗体水平中位数分别为43.06% (90/209)、185.80 IU/L;1 ~4岁和5~9岁儿童较高,分别为97.31%(181/186)、96.46%(218/226)和2448.81、1910.72 IU/L;15岁及以上人群抗体阳性率在81.98% ~90.14%之间,抗体水平在744.38 ~ 1474.84 IU/L之间.本市人口麻疹抗体阳性率和抗体水平分别为82.45%(883/1071)、899.82 IU/L,低于流动人口的87.00%(917/1054)和1166.19 IU/L,差异有统计学意义(x2=8.51,P<0.01;U =538 704.00,P<0.01).既往接种过含麻疹成分疫苗的人群抗体阳性率和抗体水平分别为91.95%(891/969) 、1443.11 IU/L,高于既往未接种疫苗和免疫史不详的人群[分别为32.95(57/173)和127.33 IU/L,86.67%(852/983)和923.73 IU/L],差异有统计学意义(x2=399.92,P<0.01;H=202.11,P <0.01).结论 北京市常住人口中,1~9岁儿童麻疹抗体水平较高,发生大范围麻疹暴发和流行的风险较小,<1岁婴儿和15 ~ 40岁本市和流动人口麻疹抗体水平有待进一步提高.
目的 瞭解北京市常住人口痳疹抗體水平.方法 2012年在北京市城區和郊區選擇連續居住6箇月以上的10箇年齡組人群作為調查對象,共2125名.採用調查問捲收集調查對象的人口學特徵、痳疹患病史、含痳疹成分疫苗免疫史,併採集靜脈血5 ml.使用ELISA檢測研究對象痳疹IgG抗體水平.結果 調查對象痳疹抗體暘性率為84.71%(1800/2125),標化暘性率為88.07%,抗體水平中位數為960.46 IU/L.不同年齡組人群中,痳疹抗體暘性率和抗體水平差異均具有統計學意義(x2 =341.60,P<0.01;H=216.27,P <0.01),其中,1歲以下嬰兒最低,抗體暘性率和抗體水平中位數分彆為43.06% (90/209)、185.80 IU/L;1 ~4歲和5~9歲兒童較高,分彆為97.31%(181/186)、96.46%(218/226)和2448.81、1910.72 IU/L;15歲及以上人群抗體暘性率在81.98% ~90.14%之間,抗體水平在744.38 ~ 1474.84 IU/L之間.本市人口痳疹抗體暘性率和抗體水平分彆為82.45%(883/1071)、899.82 IU/L,低于流動人口的87.00%(917/1054)和1166.19 IU/L,差異有統計學意義(x2=8.51,P<0.01;U =538 704.00,P<0.01).既往接種過含痳疹成分疫苗的人群抗體暘性率和抗體水平分彆為91.95%(891/969) 、1443.11 IU/L,高于既往未接種疫苗和免疫史不詳的人群[分彆為32.95(57/173)和127.33 IU/L,86.67%(852/983)和923.73 IU/L],差異有統計學意義(x2=399.92,P<0.01;H=202.11,P <0.01).結論 北京市常住人口中,1~9歲兒童痳疹抗體水平較高,髮生大範圍痳疹暴髮和流行的風險較小,<1歲嬰兒和15 ~ 40歲本市和流動人口痳疹抗體水平有待進一步提高.
목적 료해북경시상주인구마진항체수평.방법 2012년재북경시성구화교구선택련속거주6개월이상적10개년령조인군작위조사대상,공2125명.채용조사문권수집조사대상적인구학특정、마진환병사、함마진성분역묘면역사,병채집정맥혈5 ml.사용ELISA검측연구대상마진IgG항체수평.결과 조사대상마진항체양성솔위84.71%(1800/2125),표화양성솔위88.07%,항체수평중위수위960.46 IU/L.불동년령조인군중,마진항체양성솔화항체수평차이균구유통계학의의(x2 =341.60,P<0.01;H=216.27,P <0.01),기중,1세이하영인최저,항체양성솔화항체수평중위수분별위43.06% (90/209)、185.80 IU/L;1 ~4세화5~9세인동교고,분별위97.31%(181/186)、96.46%(218/226)화2448.81、1910.72 IU/L;15세급이상인군항체양성솔재81.98% ~90.14%지간,항체수평재744.38 ~ 1474.84 IU/L지간.본시인구마진항체양성솔화항체수평분별위82.45%(883/1071)、899.82 IU/L,저우류동인구적87.00%(917/1054)화1166.19 IU/L,차이유통계학의의(x2=8.51,P<0.01;U =538 704.00,P<0.01).기왕접충과함마진성분역묘적인군항체양성솔화항체수평분별위91.95%(891/969) 、1443.11 IU/L,고우기왕미접충역묘화면역사불상적인군[분별위32.95(57/173)화127.33 IU/L,86.67%(852/983)화923.73 IU/L],차이유통계학의의(x2=399.92,P<0.01;H=202.11,P <0.01).결론 북경시상주인구중,1~9세인동마진항체수평교고,발생대범위마진폭발화류행적풍험교소,<1세영인화15 ~ 40세본시화류동인구마진항체수평유대진일보제고.
Objective To analyze the measles immunity level of persistent population in Beijing.Methods A total of 2125 objects from 10 age groups,who had been living in Beijing for over 6months,were selected from urban and rural areas in Beijing in 2012.Demographic characteristics,history of measles and vaccine immunization were investigated by questionnaire.5 ml blood sample of each subject was collected,and the Measles IgG antibody was measured by ELISA assay.Results Positive rate of measles antibody was 84.71% (1800/2125) and standardized positive rate was 88.07%.Median of antibody was 960.46 IU/L.Positive rate and median of measles antibody were significantly different between population from different age groups (x2 =341.60,P < 0.01 ; H =216.27,P < 0.01).Antibody positive rate and median were lowest in the < 1 year age group,which were separately 43.06% (90/209) and 185.80 IU/L;and highest in the 1-4 (97.31% (181/186) and 2448.81 IU/L) and 5-9 years age group (96.46%(218/226) and 1910.72 IU/L).The range of antibody positive rate and median in adults of ≥ 15 years were 81.98%-90.14% and 744.38-1474.84 IU/L Antibody positive rate and median in persistent population,which were separately 82.45% (883/1071) and 899.82 IU/L,were lower than those in migrant population,which were 87.00% (917/1054) and 166.19 IU/L,respectively (x2 =8.51,P < 0.01 ; U =538 704.00,P < 0.01).Antibody positive rate and median in population with vaccination history,which were separately 91.95% (891/969) and 1443.11 IU/L,were higher than those population without vaccination history and people whose history unknown (32.95% (57/173),127.33 IU/L; 86.67% (852/983),923.73 IU/L).The difference showed statistical significance (x2 =399.92,P < 0.01 ; H =202.11,P <0.01).Conclusion Among the persistent population in China,measles antibody level among the children aging 1-9 years old was high enough to prevent outbreak and epidemic of measles.However,we should try our best to strengthen the measles antibody level among the babies younger than 1 year old and the migrant population aging between 15 and 40 years old.