中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2014年
1期
18-22
,共5页
陈科%章岚%罗红裔%王劲%李琴%毛萌
陳科%章嵐%囉紅裔%王勁%李琴%毛萌
진과%장람%라홍예%왕경%리금%모맹
维生素A%干预性研究%儿童,学龄前%铁代谢稳态
維生素A%榦預性研究%兒童,學齡前%鐵代謝穩態
유생소A%간예성연구%인동,학령전%철대사은태
Vitamin A%Intervention studies%Child,preschool%Iron metabolic homeostasis
目的 了解维生素A(vitamin A,VA)和铁剂的单独及联合补充对铁代谢稳态指标的影响.方法 采用整群抽样的方法于2011年3-9月以成都郫县地区8所幼儿园中所有3～6岁儿童作为研究对象,共445名,利用随机数字表法将其分入单独VA补充组(一次性口服VA 20万单位,VA组),单独铁剂补充组(口服补充元素铁,剂量为每天1～2 mg/kg,每周5d,时间为6个月,FE组),VA及铁剂联合补充组(VA及铁剂联合补充,VF组)、对照组(不进行VA和铁剂的补充,CO组).补充前后分别采集调查对象静脉血3 ml,检测其血红蛋白(Hb)、VA、血清铁蛋白(serumferritin,SF)、血清可溶性转铁蛋白受体(serum transferring receptor,sTfR)、C-反应蛋白(C-reactiveprotein,CRP);同时计算转铁蛋白受体-铁蛋白指数(transferring receptor-ferritin index,TFR-F)以及机体总铁含量(total body iron content,TBIC).分析干预前后不同组间各项指标的差异.结果 VA组干预前sTfR水平为(1.78 ±0.17) mg/L,高于干预后[(1.18 ±0.11)mg/L](￡=28.88,P＜0.01);干预前FE组和VF组TFR-F指数分别为1.59±0.37、1.63±0.40,TBIC分别为(9.04±2.71)、(9.26±2.33) mg/kg,均低于干预后[FE、VF组TFR-F指数分别为1.84 ±0.51、1.87 ±0.45,TBIC分别为(12.42±3.49)、(13.01±2.98) mg/kg](t值分别为3.93、3.78、7.57、9.41,P值均＜0.01);干预前VA组、FE组、VF组铁缺乏症的发病率分别为26％ (25/95)、31％ (30/98)、31％ (28/90),干预后分别为41％ (39/95)、10％(10/98)、18％(16/90),差异均有统计学意义(x2值分别为4.59、12.50、4.31,P值均＜0.05).结论 单独补充VA和铁及两者联合补充对改善铁缺乏症效果相同,VA对机体铁代谢稳态的影响主要表现在促进储备铁的动员和利用,而对机体总体含量并无影响.
目的 瞭解維生素A(vitamin A,VA)和鐵劑的單獨及聯閤補充對鐵代謝穩態指標的影響.方法 採用整群抽樣的方法于2011年3-9月以成都郫縣地區8所幼兒園中所有3～6歲兒童作為研究對象,共445名,利用隨機數字錶法將其分入單獨VA補充組(一次性口服VA 20萬單位,VA組),單獨鐵劑補充組(口服補充元素鐵,劑量為每天1～2 mg/kg,每週5d,時間為6箇月,FE組),VA及鐵劑聯閤補充組(VA及鐵劑聯閤補充,VF組)、對照組(不進行VA和鐵劑的補充,CO組).補充前後分彆採集調查對象靜脈血3 ml,檢測其血紅蛋白(Hb)、VA、血清鐵蛋白(serumferritin,SF)、血清可溶性轉鐵蛋白受體(serum transferring receptor,sTfR)、C-反應蛋白(C-reactiveprotein,CRP);同時計算轉鐵蛋白受體-鐵蛋白指數(transferring receptor-ferritin index,TFR-F)以及機體總鐵含量(total body iron content,TBIC).分析榦預前後不同組間各項指標的差異.結果 VA組榦預前sTfR水平為(1.78 ±0.17) mg/L,高于榦預後[(1.18 ±0.11)mg/L](￡=28.88,P＜0.01);榦預前FE組和VF組TFR-F指數分彆為1.59±0.37、1.63±0.40,TBIC分彆為(9.04±2.71)、(9.26±2.33) mg/kg,均低于榦預後[FE、VF組TFR-F指數分彆為1.84 ±0.51、1.87 ±0.45,TBIC分彆為(12.42±3.49)、(13.01±2.98) mg/kg](t值分彆為3.93、3.78、7.57、9.41,P值均＜0.01);榦預前VA組、FE組、VF組鐵缺乏癥的髮病率分彆為26％ (25/95)、31％ (30/98)、31％ (28/90),榦預後分彆為41％ (39/95)、10％(10/98)、18％(16/90),差異均有統計學意義(x2值分彆為4.59、12.50、4.31,P值均＜0.05).結論 單獨補充VA和鐵及兩者聯閤補充對改善鐵缺乏癥效果相同,VA對機體鐵代謝穩態的影響主要錶現在促進儲備鐵的動員和利用,而對機體總體含量併無影響.
목적 료해유생소A(vitamin A,VA)화철제적단독급연합보충대철대사은태지표적영향.방법 채용정군추양적방법우2011년3-9월이성도비현지구8소유인완중소유3～6세인동작위연구대상,공445명,이용수궤수자표법장기분입단독VA보충조(일차성구복VA 20만단위,VA조),단독철제보충조(구복보충원소철,제량위매천1～2 mg/kg,매주5d,시간위6개월,FE조),VA급철제연합보충조(VA급철제연합보충,VF조)、대조조(불진행VA화철제적보충,CO조).보충전후분별채집조사대상정맥혈3 ml,검측기혈홍단백(Hb)、VA、혈청철단백(serumferritin,SF)、혈청가용성전철단백수체(serum transferring receptor,sTfR)、C-반응단백(C-reactiveprotein,CRP);동시계산전철단백수체-철단백지수(transferring receptor-ferritin index,TFR-F)이급궤체총철함량(total body iron content,TBIC).분석간예전후불동조간각항지표적차이.결과 VA조간예전sTfR수평위(1.78 ±0.17) mg/L,고우간예후[(1.18 ±0.11)mg/L](￡=28.88,P＜0.01);간예전FE조화VF조TFR-F지수분별위1.59±0.37、1.63±0.40,TBIC분별위(9.04±2.71)、(9.26±2.33) mg/kg,균저우간예후[FE、VF조TFR-F지수분별위1.84 ±0.51、1.87 ±0.45,TBIC분별위(12.42±3.49)、(13.01±2.98) mg/kg](t치분별위3.93、3.78、7.57、9.41,P치균＜0.01);간예전VA조、FE조、VF조철결핍증적발병솔분별위26％ (25/95)、31％ (30/98)、31％ (28/90),간예후분별위41％ (39/95)、10％(10/98)、18％(16/90),차이균유통계학의의(x2치분별위4.59、12.50、4.31,P치균＜0.05).결론 단독보충VA화철급량자연합보충대개선철결핍증효과상동,VA대궤체철대사은태적영향주요표현재촉진저비철적동원화이용,이대궤체총체함량병무영향.
Objective To explore the effect of vitamin A(VA) combined iron supplements on iron metabolic homeostasis for preschoolers.Methods About 445 preschoolers with aged 3-6 years old from eight kindergartens in Pixian county,Chengdu were recruited into this trial from March to September,2011.All subjects met the inclusion criteria were randomly divided into four groups using random number table:sole VA supplementation group (VA group,a single oral dose of VA at about 200 000 units),sole iron supplementation group (FE group,daily oral supplementation with the element iron 1-2 mg · kg-1 · d-1 for five days a week,lasting for 6 months),the combined supplementation of VA and iron group (VF group) and control group (CO group,no VA and iron supplementation).The concentration of serum VA,serum ferritin (SF),serum transferring receptor (sTfR),C-reactive protein (CRP) and hemoglobin (Hb) were measured from 3 ml vein blood.The sTfR-SF index (TFR-F index) and total body iron content (TBIC) before and after intervention were calculated.The differences of these indexes between groups before and after intervention were analyzed.Results The level of sTfR before intervention in VA group ((1.78 ± 0.17) mg/L) was significantly higher than that of after intervention ((1.18 ± 0.11) mg/L) (t =28.88,P ＜0.01).The levels of TFR-F index and TBIC in FE and VF groups before intervention ((1.59 ±0.37),(1.63 ±0.40) and (9.04 ±2.71),(9.26 ±2.33) mg/kg,respectively) were all lower than those of after intervention (TFR-F index:(1.84 ± 0.51),(1.87 ± 0.45) and TBIC:(12.42 ± 3.49),(13.01 ± 2.98) mg/kg) (t values were 3.93,3.78,7.57 and 9.41,respectively,all P values were ＜ 0.01).The incidence of iron deficiency in VA,FE,and VF groups before intervention were 26％ (25/95),31％ (30/98) and 31％ (28/90)and were 41％ (39/95),10％ (10/98)and 18％ (16/90)for after intervention,respectively.The difference of this index in VA,FE and VF groups were significant (x2 values were 4.59,12.50 and 4.31,respectively,all the P values were ＜ 0.05).Conclusion Combined VA and iron was as effective as VA alone or iron alone in decreasing the iron deficiency,the impact of VA intervention on iron metabolic homeostasis was mainly manifested in iron usage and mobilization,but showed no effect on total body iron content.
