CAJ | 학술논문

目的研究细颗粒物(PM2.5)的碳质组分对动脉粥样硬化指数的影响.方法 2011年采用系统抽样的方法从天津市两个社区选取60岁以上老年人作为研究对象,排除有心血管疾病的对象,最终纳入112名.2011年12月测定每个研究对象的TC、TG、HDL-C、LDL-C的水平和个体PM2.5暴露水平,并检测PM25的总碳(TC)、有机碳(OC)和元素碳(EC)的浓度,计算动脉粥样硬化指数(AIP).结果 112名老年人的AIP值为0.05±0.26,PM2.5的个体暴露浓度为(164.75±110.67)μg/m3,PM2.5的碳质组分TC、OC、EC的浓度分别为(53.86±29.65)、(44.93 ±26.37)、(9.49±5.75)μg/m3.Pearson相关分析发现,AIP与TC、OC、EC的散点图显示出明显的线性趋势,AIP与TC、OC、EC浓度均呈正相关(相关系数r分别为0.307、0.287、0.252,P值均＜0.05).多元logistic回归显示,以AIP风险分类为应变量,以低风险组作为参照组,中度风险组的TC、OC、EC的回归系数和OR值均无统计学意义(P＞0.05);高风险组的TC、OC、EC暴露水平的OR(95％ CI)值分别为1.03(95％ CI:1.01 ～1.05),1.03(95％ CI:1.01 ～1.05)和1.12(95％ CI:1.02 ～ 1.22).结论 AIP与PM2.5的碳质组分TC、OC、EC有关联,PM2.5的碳质组分是动脉粥样硬化的危险因素.
목적 연구세과립물(PM2.5)적탄질조분대동맥죽양경화지수적영향.방법 2011년채용계통추양적방법종천진시량개사구선취60세이상노년인작위연구대상,배제유심혈관질병적대상,최종납입112명.2011년12월측정매개연구대상적TC、TG、HDL-C、LDL-C적수평화개체PM2.5폭로수평,병검측PM25적총탄(TC)、유궤탄(OC)화원소탄(EC)적농도,계산동맥죽양경화지수(AIP).결과 112명노년인적AIP치위0.05±0.26,PM2.5적개체폭로농도위(164.75±110.67)μg/m3,PM2.5적탄질조분TC、OC、EC적농도분별위(53.86±29.65)、(44.93 ±26.37)、(9.49±5.75)μg/m3.Pearson상관분석발현,AIP여TC、OC、EC적산점도현시출명현적선성추세,AIP여TC、OC、EC농도균정정상관(상관계수r분별위0.307、0.287、0.252,P치균＜0.05).다원logistic회귀현시,이AIP풍험분류위응변량,이저풍험조작위삼조조,중도풍험조적TC、OC、EC적회귀계수화OR치균무통계학의의(P＞0.05);고풍험조적TC、OC、EC폭로수평적OR(95％ CI)치분별위1.03(95％ CI:1.01 ～1.05),1.03(95％ CI:1.01 ～1.05)화1.12(95％ CI:1.02 ～ 1.22).결론 AIP여PM2.5적탄질조분TC、OC、EC유관련,PM2.5적탄질조분시동맥죽양경화적위험인소.
Objective To evaluate associations between carbon constituents of fine particulate matter (PM2.5) and atherogenic index of plasma (AIP).Methods We collected subjects from two communities by a system sampling,and 112 people aged over 60 years old without cardiovascular disease were recruited.The levels of cholesterol (TC),triglycerides (TG),high-density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C) of objects,and personal exposure to PM2.5 were measured on December,2011.Total carbon (TC),organic carbon (OC) and elemental carbon (EC) of PM2.5 were detected and AIP was calculated according to its definition.Results The value of AIP among the 112 subjects was 0.05 ± 0.26.Personal exposure concentration of PM2.5 and its carbon components (TC,OC and EC) were (164.75 ± 110.67),(53.86 ± 29.65),(44.93 ± 26.37) and (9.49 ± 5.75) μg/m3,respectively.The Pearson analysis showed the linear relationship between TC,OC,EC and AIP,all significant positive correlations.The correlation coefficients were TC (r =0.307,P ＜0.05),OC (r =0.287,P ＜0.05) and EC (r =0.252,P ＜ 0.05),respectively.The multiple logistic regression analysis showed that when the AlP risk categories were selected as dependent variable and low risk group as reference group,the regression coefficient of TC,OC and EC was separately 1.03 (95 ％ CI:1.01-1.05),1.03 (95 ％ CI:1.01-1.05),1.12 (95％ CI:1.02-1.22) in the high risk group; while there was no statistical significance of the regression coefficient and OR in the middle risk group.Conclusion There was stable associations between the carbon constituents (TC,OC and EC) of fine Particulate Matter (PM2.5) and AIP.The findings suggested that carbon components of PM2.5 should be considered as risk factors of athergenic.