CAJ | 학술논문

目的探讨环氧化酶-2(COX-2)-765G＞C基因多态性与结直肠癌(CRC)易感性的关联.方法计算机检索Pubmed、EMABSE、CJFD、CBM、CNKI、VIP及万方数据库,检索时间截至2013年3月1日,收集关于COX-2-765G＞C基因多态性与结直肠癌易感性的病例-对照研究,初筛得到99篇文献.由2名评价者按照纳入和排除标准独立选择文献、提取资料、评价质量,采用RevMan 5.1和Stata12.0软件进行Meta分析.结果最终纳入11个病例-对照研究,包括3432例患者和5286名对照.纳入的结果除在GC/GG基因型的比较模型中存在异质性(I2 =52％,P=0.03)外,其他三种遗传模型同质性较好.各遗传模型Meta分析结果显示:COX-2-765G＞C基因多态性与结直肠癌易感性的关联性无统计学意义[显性遗传模型:(GC+ CC)/GG:OR=1.08,95％ CI:0.96 ～ 1.21;隐性遗传模型:CC/(GC+ GG):OR=1.09,95％ CI:0.76～ 1.56;共显性遗传模型:GC/GG:OR=1.05,95％ CI:0.87 ～ 1.28;CC/GG:OR=1.11,95％ CI:0.77～1.60].基于人群的亚组分析显示:COX-2-765G＞C基因多态性可增加黄种人群罹患结直肠癌的风险[(GC+ CC)/GG:OR=1.41,95％ CI:1.15 ～ 1.75;GC/GG:OR=1.48,95％ CI:1.15～1.90],而对白种人群结直肠癌易感性无明显关联.结论 COX-2-765G＞C基因多态性可增加黄种人群结直肠癌的易感性.
목적 탐토배양화매-2(COX-2)-765G＞C기인다태성여결직장암(CRC)역감성적관련.방법 계산궤검색Pubmed、EMABSE、CJFD、CBM、CNKI、VIP급만방수거고,검색시간절지2013년3월1일,수집관우COX-2-765G＞C기인다태성여결직장암역감성적병례-대조연구,초사득도99편문헌.유2명평개자안조납입화배제표준독립선택문헌、제취자료、평개질량,채용RevMan 5.1화Stata12.0연건진행Meta분석.결과 최종납입11개병례-대조연구,포괄3432례환자화5286명대조.납입적결과제재GC/GG기인형적비교모형중존재이질성(I2 =52％,P=0.03)외,기타삼충유전모형동질성교호.각유전모형Meta분석결과현시:COX-2-765G＞C기인다태성여결직장암역감성적관련성무통계학의의[현성유전모형:(GC+ CC)/GG:OR=1.08,95％ CI:0.96 ～ 1.21;은성유전모형:CC/(GC+ GG):OR=1.09,95％ CI:0.76～ 1.56;공현성유전모형:GC/GG:OR=1.05,95％ CI:0.87 ～ 1.28;CC/GG:OR=1.11,95％ CI:0.77～1.60].기우인군적아조분석현시:COX-2-765G＞C기인다태성가증가황충인군리환결직장암적풍험[(GC+ CC)/GG:OR=1.41,95％ CI:1.15 ～ 1.75;GC/GG:OR=1.48,95％ CI:1.15～1.90],이대백충인군결직장암역감성무명현관련.결론 COX-2-765G＞C기인다태성가증가황충인군결직장암적역감성.
Objective To explore the correlation between polymorphism of cyclooxygenase-2 (COX-2)-765G ＞ C and susceptibility to colorectal cancer.Methods All eligible case-control studies published up to March 2013 were searched out from PubMed,EMABSE,CJFD,CBM,CNKI,VIP and WanFang databases,while 99 articles were concluded.Two reviewers independently identified the literature according to inclusion and exclusion criteria.Meta-analysis was performed using RevMan 5.1 and Stata 12.0 software.Results A total of eleven studies comprising 3432 cases and 5286 controls were finally included.The included studies showed good homogeneity in the three genetic models,except the model of GC/GG genotype (I2 =52％,P =0.03).Overall,there were no significant association between polymorphism of COX-2-765 G ＞ C and the susceptibility to colorectal cancer (dominant model:(GC + CC)/GG:OR =1.08,95％ CI:0.96-1.21 ; recessive model:CC/(GC + GG):OR =1.09,95％ CI:0.76-1.56; GC/GG:OR =1.05,95％ CI:0.87-1.28; CC/GG:OR =1.11,95％ CI:0.77-1.60).In stratification analysis by ethnicity,we observed that the polymorphism of COX-2-765G ＞ C could increase the susceptibility to colorectal cancer among yellow populations ((GC + CC)/GG:OR =1.41,95％ CI:1.15-1.75 ; GC/ GG:OR =1.48,95％ CI:1.15-1.90),but there was no significant association found among Caucasian populations.Conclusion This meta-analysis suggested that the polymorphism of COX-2-765G ＞ C may increase the susceptibility to colorectal cancer in the yellow population.