CAJ | 학술논문

目的调查我国一般人群血和尿砷水平,分析其影响因素.方法于2009-2010年,采用整群随机抽样的方法在我国东部、西部和中部8个省份的24个市县抽取了18 120名6～ 60岁人群为研究对象,分别采集血液和尿液样品.应用电感耦合等离子体质谱法检测血和尿液中的砷水平,分析年龄、性别和区域以及生活方式对血砷和尿砷水平的影响.结果我国一般人群全血中砷含量的几何均数为2.33μg/L;男性(2.35μg/L)高于女性(2.30 μg/L)(Z=-1.42,P＜0.05);东、中、西部地区人群分别为2.94、1.30和0.98 μg/L(x2=643.22,P＜0.05);吸烟人群(2.84 μg/L)高于不吸烟人群(2.27 μg/L)(Z=-6.28,P＜ 0.05);摄食海鲜人群(2.59 μg/L)高于不摄食海鲜人群(1.47 μg/L)(Z=-23.68,P＜0.05).我国一般人群尿砷的几何均数为13.72 μg/L;男性(14.10 μg/L)高于女性(13.33 μg/L)(Z=-3.94,P＜0.05);东、中和西部地区人群分别为14.14、16.02和9.57μg/L (x2 =353.89,P＜0.05);吸烟人群(16.06 μg/L)高于不吸烟人群(13.70μg/L)(Z=-2.63,P＜0.05);摄食海鲜人群(14.82 μg/L)高于不摄食海鲜人群(10.99μg/L)(Z=-3.20,P＜0.05).血砷和尿砷水平相关系数为0.285,P＜0.05.结论我国一般人群血砷和尿砷水平存在性别及地区差异,同时与生活方式有关;血砷和尿砷水平呈正相关.
목적 조사아국일반인군혈화뇨신수평,분석기영향인소.방법 우2009-2010년,채용정군수궤추양적방법재아국동부、서부화중부8개성빈적24개시현추취료18 120명6～ 60세인군위연구대상,분별채집혈액화뇨액양품.응용전감우합등리자체질보법검측혈화뇨액중적신수평,분석년령、성별화구역이급생활방식대혈신화뇨신수평적영향.결과 아국일반인군전혈중신함량적궤하균수위2.33μg/L;남성(2.35μg/L)고우녀성(2.30 μg/L)(Z=-1.42,P＜0.05);동、중、서부지구인군분별위2.94、1.30화0.98 μg/L(x2=643.22,P＜0.05);흡연인군(2.84 μg/L)고우불흡연인군(2.27 μg/L)(Z=-6.28,P＜ 0.05);섭식해선인군(2.59 μg/L)고우불섭식해선인군(1.47 μg/L)(Z=-23.68,P＜0.05).아국일반인군뇨신적궤하균수위13.72 μg/L;남성(14.10 μg/L)고우녀성(13.33 μg/L)(Z=-3.94,P＜0.05);동、중화서부지구인군분별위14.14、16.02화9.57μg/L (x2 =353.89,P＜0.05);흡연인군(16.06 μg/L)고우불흡연인군(13.70μg/L)(Z=-2.63,P＜0.05);섭식해선인군(14.82 μg/L)고우불섭식해선인군(10.99μg/L)(Z=-3.20,P＜0.05).혈신화뇨신수평상관계수위0.285,P＜0.05.결론 아국일반인군혈신화뇨신수평존재성별급지구차이,동시여생활방식유관;혈신화뇨신수평정정상관.
Objective To evaluated the levels of arsenic (As) in blood and urine among general population in China and analyze its influencing factors.Methods A total of 18 120 subjects from general population aged 6-60 years were recruited from 24 districts in 8 provinces in eastern,central and western China mainland from 2009 to 2010,by cluster random sampling method.Blood samples and urine samples were collected,the information of the life-style was collected by questionnaire.Inductive coupled plasma mass spectrometry was applied to test the As level in the samples,and the distribution of As in blood and urine for different ages,genders,areas and life habits were then analyzed.Results The geometric mean (GM)of blood As concentration among general population was 2.33 μg/L;the GM of blood As in male(2.35 μg/L)was higher than and female(2.30 μg/L) (Z =-1.42,P ＜ 0.05) ;from eastern,central to western China,the blood As level were 2.94,1.30 and 0.98 μg/L(x2 =643.22,P ＜ 0.05),respectively; the GM in smokers (2.84 μg/L) was higher than non-smokers (2.27) (Z =-6.28,P ＜ 0.05) ; the seafood consumer had a higher blood As level (2.59 μg/L) than people not consuming seafood (1.47 μg/L) (Z =-23.68,P ＜0.05).The urine As level of the whole population was 13.72 μg/L;while its GM in male(14.10 μg,/L)was higher than female(13.33 μg/L) (Z =-3.94,P ＜ 0.05) ; the values from eastern,central to western China were 14.14,16.02 and 9.57 μg/L(x2 =353.89,P ＜ 0.05),respectively; the level in smokers(16.06 μg/L)was higher than nonsmokers(13.70 μg/L) (Z =-2.63,P ＜0.05) ;the level in seafood consumers(14.82 μg/L) was higher than people not consuming seafood(10.99 μg/L) (Z =-3.20,P ＜ 0.05).The blood As level had a positive correlation with urine As level (correlation coefficient:0.285,P ＜ 0.05).Conclusion The As level in blood and urine varied by gender and area among general population in China,and related to lifestyles.There was a positive correlation between As level in blood and that in urine.