中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2014年
2期
128-132
,共5页
蔡于茂%刘惠%宋亚娟%洪福昌
蔡于茂%劉惠%宋亞娟%洪福昌
채우무%류혜%송아연%홍복창
HIV%梅毒%感染%横断面研究%男男性行为者%献血
HIV%梅毒%感染%橫斷麵研究%男男性行為者%獻血
HIV%매독%감염%횡단면연구%남남성행위자%헌혈
HIV%Syphilis%Infection%Cross-sectional studies%Men who have sex with men%Blood donation
目的 了解深圳市男男性行为献血者(men who have sex with men blood donors,MSMBD) HIV和梅毒感染现状及其影响因素.方法 于2009-2012年采用滚雪球法和同伴推动抽样方法在深圳市招募了813名MSMBD.采用一对一问卷调查方法收集其社会人口学特征、HIV主动检测史、性取向、性角色、最近6个月男男性行为状况、异性性行为状况等,采集静脉血5 ml进行梅毒螺旋体抗体检测和抗-HIV检测.采用Cochran-Armitage趋势检验比较各年梅毒和HIV阳性率差异;采用单因素和多因素非条件logistic回归分析梅毒和HIV感染的影响因素.结果 调查对象的梅毒感染率为22.0％(179/813),HIV感染率为8.0％ (65/813),梅毒合并HIV感染率为4.2％ (34/813).多因素logistic回归分析结果显示,与无HIV主动检测史相比,有主动检测史会降低MSMBD人群感染HIV的风险[OR(95％ CI) =0.37(0.21 ～0.64)],与6个月内肛交性伴数≤1个、无合并梅毒感染相比,6个月内肛交性伴数≥5个、合并梅毒感染会增加其感染HIV的风险[OR(95％ CI)值分别为2.04(1.03 ～4.06)、4.52(2.64～7.73)];与性取向为同性恋、6个月内肛交性伴数≤1个、肛交时每次使用安全套、无合并HIV感染相比,性取向为双性恋、6个月内肛交性伴数为2～4个和≥5个、肛交时有时使用安全套、合并HIV感染会增加MSMBD人群感染梅毒的风险[OR(95％CI)值分别为1.60(1.12～2.27)、1.77(1.09 ～2.87)、1.84(1.09 ～3.08)、1.61(1.10 ～ 2.36)、4.02(2.33 ～6.96)].结论 深圳市MSMBD HIV和梅毒感染率较高,影响因素复杂,应引起足够重视,确保血液安全.
目的 瞭解深圳市男男性行為獻血者(men who have sex with men blood donors,MSMBD) HIV和梅毒感染現狀及其影響因素.方法 于2009-2012年採用滾雪毬法和同伴推動抽樣方法在深圳市招募瞭813名MSMBD.採用一對一問捲調查方法收集其社會人口學特徵、HIV主動檢測史、性取嚮、性角色、最近6箇月男男性行為狀況、異性性行為狀況等,採集靜脈血5 ml進行梅毒螺鏇體抗體檢測和抗-HIV檢測.採用Cochran-Armitage趨勢檢驗比較各年梅毒和HIV暘性率差異;採用單因素和多因素非條件logistic迴歸分析梅毒和HIV感染的影響因素.結果 調查對象的梅毒感染率為22.0％(179/813),HIV感染率為8.0％ (65/813),梅毒閤併HIV感染率為4.2％ (34/813).多因素logistic迴歸分析結果顯示,與無HIV主動檢測史相比,有主動檢測史會降低MSMBD人群感染HIV的風險[OR(95％ CI) =0.37(0.21 ～0.64)],與6箇月內肛交性伴數≤1箇、無閤併梅毒感染相比,6箇月內肛交性伴數≥5箇、閤併梅毒感染會增加其感染HIV的風險[OR(95％ CI)值分彆為2.04(1.03 ～4.06)、4.52(2.64～7.73)];與性取嚮為同性戀、6箇月內肛交性伴數≤1箇、肛交時每次使用安全套、無閤併HIV感染相比,性取嚮為雙性戀、6箇月內肛交性伴數為2～4箇和≥5箇、肛交時有時使用安全套、閤併HIV感染會增加MSMBD人群感染梅毒的風險[OR(95％CI)值分彆為1.60(1.12～2.27)、1.77(1.09 ～2.87)、1.84(1.09 ～3.08)、1.61(1.10 ～ 2.36)、4.02(2.33 ～6.96)].結論 深圳市MSMBD HIV和梅毒感染率較高,影響因素複雜,應引起足夠重視,確保血液安全.
목적 료해심수시남남성행위헌혈자(men who have sex with men blood donors,MSMBD) HIV화매독감염현상급기영향인소.방법 우2009-2012년채용곤설구법화동반추동추양방법재심수시초모료813명MSMBD.채용일대일문권조사방법수집기사회인구학특정、HIV주동검측사、성취향、성각색、최근6개월남남성행위상황、이성성행위상황등,채집정맥혈5 ml진행매독라선체항체검측화항-HIV검측.채용Cochran-Armitage추세검험비교각년매독화HIV양성솔차이;채용단인소화다인소비조건logistic회귀분석매독화HIV감염적영향인소.결과 조사대상적매독감염솔위22.0％(179/813),HIV감염솔위8.0％ (65/813),매독합병HIV감염솔위4.2％ (34/813).다인소logistic회귀분석결과현시,여무HIV주동검측사상비,유주동검측사회강저MSMBD인군감염HIV적풍험[OR(95％ CI) =0.37(0.21 ～0.64)],여6개월내항교성반수≤1개、무합병매독감염상비,6개월내항교성반수≥5개、합병매독감염회증가기감염HIV적풍험[OR(95％ CI)치분별위2.04(1.03 ～4.06)、4.52(2.64～7.73)];여성취향위동성련、6개월내항교성반수≤1개、항교시매차사용안전투、무합병HIV감염상비,성취향위쌍성련、6개월내항교성반수위2～4개화≥5개、항교시유시사용안전투、합병HIV감염회증가MSMBD인군감염매독적풍험[OR(95％CI)치분별위1.60(1.12～2.27)、1.77(1.09 ～2.87)、1.84(1.09 ～3.08)、1.61(1.10 ～ 2.36)、4.02(2.33 ～6.96)].결론 심수시MSMBD HIV화매독감염솔교고,영향인소복잡,응인기족구중시,학보혈액안전.
Objective To investigate the distribution and factors associated with HIV and syphilis infection among Men who have sex with men blood donors (MSMBD) in Shenzhen.Methods A total of 813 MSMBD were recruited using snowball sampling and respondent driven sampling from 2009 to 2012 in Shenzhen.Questionnaire-based interviews were conducted on a one-on-one basis.Data were collected including socio-demographic information,HIV testing history,self-identified sexual orientation,role in homosexual behavior,information about having sex with male sexual partners in the past six months and information about having sex with female sexual partners in the past six months.5 ml blood samples were taken and tested for treponema pallidum and HIV antibodies.Comparisons of syphilis and HIV infection among different years were analyzed by the Cochran-Armitage trend test.Factors associated with syphilis and HIV infection were analyzed by the univariate logistic regression and multivariate unconditional logistic regression.Results The prevalence of syphilis,HIV,and syphilis-HIV co-infection among 813 participants were 22.0％ (179/813),8.0％ (65/813),and 4.2％ (34/813),respectively.In the multivariate logistic regression analysis,ever tested for HIV (versus without HIV testing history,OR (95％ CI) =0.369 (0.213-0.641))will decrease the risk of HIV infection among MSMBD in comparison with never tested for HIV(OR(95％CI) =0.37(0.21-0.64));having five or more anal sexual partners in the past six months and coinfected with syphilis will increase the risk of HIV infection among MSMBD in comparison with having 0-1 sexual partners(OR (95％ CI) =2.04 (1.03-4.06)) and negative syphilis (OR (95％ CI) =4.52 (2.64-7.73)),respectively,bisexual orientation,having 2-4 anal sexual partners and having five or more anal sexual partners in the past six months,using condoms not for every act of anal sex,co-infected with HIV will increase the risk of syphilis infection among MSMBD in comparison with homosexual orientation(OR(95％ CI) =1.60(1.12-2.27)),having 0-1 sexual partner in the past six months(OR(95％ CI) =1.77 (1.09-2.87) and OR(95％ CI) =1.84 (1.09-3.08)),using condoms for every act of anal sex (OR (95％ CI) =1.61 (1.10-2.36)) and negative HIV(OR(95％ CI) =4.02(2.33-6.96)),respectively.Conclusion The prevalence of HIV and syphilis among MSMBD in Shenzhen are much higher with complex influence factors.The relevant government should pay great attention to it and ensure the blood safety.
