CAJ | 학술논문

目的探讨人尿中异硫氰酸酯(ITC)水平与胰腺癌发病风险的关系.方法采用病例-对照研究方法,利用新建立的“快速病例报告系统”收集2006年12月至2008年12月期间确诊的胰腺癌病例的资料和生物样本,应用高效液相色谱法对390例胰腺癌病例和414名对照者尿液中ITC代谢量进行测定,应用食物频率问卷调查十字花科蔬菜和ITC的摄人情况,采用非条件logistic回归模型分析ITC和胰腺癌的关系.结果病例组中十字花科蔬菜摄入量、膳食ITC水平和尿液ITC代谢量的中位数(P25,P75)分别为95.0(66.9,135.8) g/d、11.0(7.1,16.0)μmol/d、0.95 (0.12,2.92) μmol/g肌酐；对照组分别为107.4(80.1,154.1)g/d、12.3(8.0,18.0) μmol/d、1.78(0.53,5.28)μmol/g肌酐；病例组均低于对照组,差异有统计学意义(t值分别为3.75、3.03、4.40,P值均＜0.01).对照人群中尿液ITC代谢量随十字花科蔬菜、ITC摄入量增加而升高(r值分别为0.189、0.201,P值均＜0.01).将对照组的尿液ITC代谢量划分三分位数,以最低组(＜0.825μmol/g肌酐)为参照组,调整了年龄、性别、糖尿病史、胰腺炎史等混杂因素后,发现尿液中ITC的水平与患胰腺癌的风险呈负相关,尿ITC水平较高组(0.825 ～3.342 μmol/g肌酐)、最高组(≥3.343 μmol/g肌酐)的OR(95％ CI)值分别为0.69(0.49～0.97)和0.47(0.33 ～0.68),P趋势值＜0.01.结论增加ITC的摄人量可能降低胰腺癌的发病风险.
목적 탐토인뇨중이류청산지(ITC)수평여이선암발병풍험적관계.방법 채용병례-대조연구방법,이용신건립적“쾌속병례보고계통”수집2006년12월지2008년12월기간학진적이선암병례적자료화생물양본,응용고효액상색보법대390례이선암병례화414명대조자뇨액중ITC대사량진행측정,응용식물빈솔문권조사십자화과소채화ITC적섭인정황,채용비조건logistic회귀모형분석ITC화이선암적관계.결과 병례조중십자화과소채섭입량、선식ITC수평화뇨액ITC대사량적중위수(P25,P75)분별위95.0(66.9,135.8) g/d、11.0(7.1,16.0)μmol/d、0.95 (0.12,2.92) μmol/g기항；대조조분별위107.4(80.1,154.1)g/d、12.3(8.0,18.0) μmol/d、1.78(0.53,5.28)μmol/g기항；병례조균저우대조조,차이유통계학의의(t치분별위3.75、3.03、4.40,P치균＜0.01).대조인군중뇨액ITC대사량수십자화과소채、ITC섭입량증가이승고(r치분별위0.189、0.201,P치균＜0.01).장대조조적뇨액ITC대사량화분삼분위수,이최저조(＜0.825μmol/g기항)위삼조조,조정료년령、성별、당뇨병사、이선염사등혼잡인소후,발현뇨액중ITC적수평여환이선암적풍험정부상관,뇨ITC수평교고조(0.825 ～3.342 μmol/g기항)、최고조(≥3.343 μmol/g기항)적OR(95％ CI)치분별위0.69(0.49～0.97)화0.47(0.33 ～0.68),P추세치＜0.01.결론 증가ITC적섭인량가능강저이선암적발병풍험.
Objective To investigate the association between urinary levels of isothiocyanates (ITCs) and the risk of pancreatic cancer in urban Shanghai.Methods A case-control study has been conducted in urban Shanghai.The cases (from December 2006 to December 2008) were identified through an newly established "instant case reporting" system.The high performance liquid chromatography (HPLC) method was applied to determine the urinary levels of isothiocyanates in 390 cases and 414 controls.A foodfrequency questionnaire was administered to estimate cruciferous vegetables consumption and dietary ITC exposure.Non-conditional logistic regression model was used to analyze the relationship between dietary and urinary levels of isothiocyanates and the risk of pancreatic cancer.Results The cruciferous vegetables intake and ITC consumption,urinary ITC levels (median (P25,P75)) were 95.0 (66.9,135.8) g/d,11.0 (7.1,16.0) μmol/d,0.95 (0.12,2.92) μmol/g Cr respectively in cases,all lower than those in controls,separately 107.4 (80.1,154.1) g/d,12.3 (8.0,18.0) μmol/d,1.78 (0.53,5.28) μmol/g Cr.The differences were statistically significant (t =3.75,3.03,4.40,all P values ＜ 0.01).Urinary levels of ITCs in controls were correlated with cruciferous vegetables consumption and dietary ITC exposure (r =0.189,0.201,all P values ＜0.01).There was inverse association between urinary ITCs and the risk of pancreatic cancer after adjusting for possible confounding factors such as age,sex,history of diabetes and pancreatitis.Compared with the first tertile (＜0.825 μmol/g Cr),the odds ratio (95％ CI) for the second (0.825-3.342 μmol/g Cr) and third tertiles (≥ 3.343 μmol/g Cr) were 0.69 (0.49-0.97) and 0.47 (0.33-0.68),respectively,Ptrend ＜ 0.01.High levels of cruciferous vegetables or ITC consumption were associated with a reduced risk of pancreatic cancer (all Ptrend ＜ 0.05).Conclusion Results indicated that high levels of dietary ITC exposure might reduce the risk of pancreatic cancer.