CAJ | 학술논문

目的调查西安市强制戒毒人员乙型肝炎(简称乙肝)病毒(HBV)感染现状及乙肝疫苗接种情况.方法于2013年3-6月,对西安市某家强制戒毒所所内的545名强制戒毒人员进行问卷调查,采集静脉血3 ～5 ml,检测其乙肝表面抗原(HBsAg)、核心抗体(抗-HBc)和表面抗体(抗-HBs),比较不同特征调查对象HBV感染指标阳性率及疫苗接种率差异.结果 HBsAg、抗-HBc、抗-HBs的阳性率分别为29.4％(160/545)、60.0％(327/545)、56.1％(306/545),3项均为阴性者85名(15.6％).注射吸毒者HBsAg阳性率为40.0％(94/235),抗-HBc阳性率为65.5％(154/235),均高于非注射吸毒者[21.6％ (52/241)、58.5％(141/241)]和注射、非注射混用者[20.3％(14/69)、46.4％ (32/69)](x2值分别为23.52、9.02,P值均＜0.05).强制戒毒前1年内吸毒频次≥1次/d者HBsAg阳性率[30.6％ (153/500)]高于2～3次/周者[15.6％ (7/45)](x2=4.51,P＜0.05).乙肝疫苗接种率为11.7％ (64/545).小学以下文化程度调查对象的接种率[3.5％ (5/141)]低于高中以上[10.9％ (14/128)]和初中文化程度[16.3％ (45/276)](x2=26.61,P＜0.05).≥45岁组接种率[7.8％ (12/153)]低于＜30[15.9％ (21/132)]、30 ～44[11.9％ (31/260)]岁组(x2=30.36,P＜0.05).接种者抗-HBs阳性率[73.4％(47/64)]高于未接种者[53.8％ (259/481)](x2=8.81,P=0.003),其HBsAg阳性率[16.7％ (11/64)]低于未接种者[31.0％ (149/481)](x2=5.18,P=0.023).结论西安市强制戒毒人员HBV感染状况较严重,乙肝疫苗接种率较低.
목적 조사서안시강제계독인원을형간염(간칭을간)병독(HBV)감염현상급을간역묘접충정황.방법 우2013년3-6월,대서안시모가강제계독소소내적545명강제계독인원진행문권조사,채집정맥혈3 ～5 ml,검측기을간표면항원(HBsAg)、핵심항체(항-HBc)화표면항체(항-HBs),비교불동특정조사대상HBV감염지표양성솔급역묘접충솔차이.결과 HBsAg、항-HBc、항-HBs적양성솔분별위29.4％(160/545)、60.0％(327/545)、56.1％(306/545),3항균위음성자85명(15.6％).주사흡독자HBsAg양성솔위40.0％(94/235),항-HBc양성솔위65.5％(154/235),균고우비주사흡독자[21.6％ (52/241)、58.5％(141/241)]화주사、비주사혼용자[20.3％(14/69)、46.4％ (32/69)](x2치분별위23.52、9.02,P치균＜0.05).강제계독전1년내흡독빈차≥1차/d자HBsAg양성솔[30.6％ (153/500)]고우2～3차/주자[15.6％ (7/45)](x2=4.51,P＜0.05).을간역묘접충솔위11.7％ (64/545).소학이하문화정도조사대상적접충솔[3.5％ (5/141)]저우고중이상[10.9％ (14/128)]화초중문화정도[16.3％ (45/276)](x2=26.61,P＜0.05).≥45세조접충솔[7.8％ (12/153)]저우＜30[15.9％ (21/132)]、30 ～44[11.9％ (31/260)]세조(x2=30.36,P＜0.05).접충자항-HBs양성솔[73.4％(47/64)]고우미접충자[53.8％ (259/481)](x2=8.81,P=0.003),기HBsAg양성솔[16.7％ (11/64)]저우미접충자[31.0％ (149/481)](x2=5.18,P=0.023).결론 서안시강제계독인원HBV감염상황교엄중,을간역묘접충솔교저.
Objective To explore seroepidemiological status and vaccine coverage of hepatitis B among drug users in Xi'an.Methods 545 drug users in the Xi'an Compulsory Detoxification Center were asked to answer questionnaire and provide blood sample (3-5 ml) for test of HBsAg,anti-HBc and anti-HBs from March to June 2013.Totally,545 subjects were surveyed and tested.All of them effectively completed the survey.Results The positive rates of HBsAg,anti-HBc and anti-HBs were 29.4％ (160/545),60.0％ (327/545) and 56.1％ (306/545),respectively.Eighty five subjects (15.6％) were negative for all of the three markers.The prevalence of HBsAg and anti-HBc among injection drug users were 40.0％ (94/235) and 65.6％ (154/235),which was significantly higher than non-injection drug users' (21.6％ (52/241),58.5％ (141/241)) and mixed non-injection and injection drug users ((20.3％ (14/69),46.4％ (32/69)) (x2 =23.518 and 9.017,respectively,P ＜ 0.05).The HBsAg positive rate (30.6％ (153/500)) of subjects with more than once per day of drug using within one year was significantly higher than those who used drugs for 2-3 times per week (15.6％ (7/45))(x2 =4.51,P ＜ 0.05).Only 11.7％ (64/545) of drug users had a clear history of hepatitis B vaccination.The vaccination rate of subjects (3.5％ (5/141)) with primary education or below was significantly lower than those with high school (16.3％ (45/276)) (x2 =26.61,P ＜ 0.05).The vaccination rate of subjects (7.8％ (12/153)) over 45 years old was significantly lower than that of subjects below 30 years old (15.9％ (21/132)) and 30-44 years old (11.9％ (31/260)) (x2 =30.36,P ＜ 0.05).The vaccinees had a significantly higher positive rate of anti-HBs (73.4％ (47/64)) than those who without vaccination (53.8％ (259/481)) (x2 =8.81,P =0.003),but the positive rates of HBsAg (16.7％ (11/64))were lower than those who without vaccination (31.0％ (149/481)) (x2 =23.52 and 9.02,respectively; P ＞ 0.05).Conclusion The HBV infection status among drug users in Xi'an was in serious condition,while a low vaccination rate was also discovered among them.