中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2009年
9期
805-808
,共4页
糖尿病视网膜病变%血清白蛋白%C反应蛋白质
糖尿病視網膜病變%血清白蛋白%C反應蛋白質
당뇨병시망막병변%혈청백단백%C반응단백질
Diabetic retinopathy%Serum albumin%C-reactive protein
目的 探讨2型糖尿病并发视网膜病变(DR)患者血清缺血修饰白蛋白(IMA)和超敏C-反应蛋白(hs-CRP)浓度的变化.方法 病例对照研究.采用酶联免疫吸附测定法和速率散射比浊法检测79例DR组患者血清IMA和hs-CRP浓度变化,并与83例非DR(NDR)糖尿病组患者和72例对照组受检者进行比较,同时将40例增殖性DR(PDR)组患者与39例非增殖性DR(NPDR)组患者进行比较.采用PPMS 1.5统计学软件进行数据分析.两组均数比较采用t检验;多组均数比较采用单因素三水平设计定量资料方差分析,多个均数之间两两比较采用q检验.结果 DR组患者血清IMA浓度(46.51±13.29)μg/L,hs-CRP浓度(4.27±2.24)mg/L;NDR组患者血清IMA浓度(25.47±9.33)μg/L,hs-CRP浓度(2.96±1.84)mg/L;对照组血清IMA浓度(15.36±4.27)μg/L,hs-CRP浓度(1.86±0.97)mg/L;PDR组患者血清IMA浓度(54.72±15.61)μg/L,hs-CRP浓度(6.34±3.53)mg/L;NPDR组患者血清IMA浓度(38.35±11.27)μg/L,hs-CRP浓度(3.28±1.77)mg/L.DR组患者血清IMA和hs-CRP浓度明显高于对照组和NDR组,NDR组患者血清IMA和hs-CRP浓度高于对照组,差异有统计学意义(F=197.124,34.561;q=5.41～27.34;P<0.01);PDR组患者血清IMA和hs-CRP浓度明显高于NPDR患者组,差异有统计学意义(t=5.46,4.89;P<0.01);DR组患者血清IMA与hs-CRP浓度呈正相关(r=0.617,P<0.01).结论 DR患者血清IMA和hs-CRP浓度明显升高,且与病情严重程度呈正相关,可能影响DR的发展.
目的 探討2型糖尿病併髮視網膜病變(DR)患者血清缺血脩飾白蛋白(IMA)和超敏C-反應蛋白(hs-CRP)濃度的變化.方法 病例對照研究.採用酶聯免疫吸附測定法和速率散射比濁法檢測79例DR組患者血清IMA和hs-CRP濃度變化,併與83例非DR(NDR)糖尿病組患者和72例對照組受檢者進行比較,同時將40例增殖性DR(PDR)組患者與39例非增殖性DR(NPDR)組患者進行比較.採用PPMS 1.5統計學軟件進行數據分析.兩組均數比較採用t檢驗;多組均數比較採用單因素三水平設計定量資料方差分析,多箇均數之間兩兩比較採用q檢驗.結果 DR組患者血清IMA濃度(46.51±13.29)μg/L,hs-CRP濃度(4.27±2.24)mg/L;NDR組患者血清IMA濃度(25.47±9.33)μg/L,hs-CRP濃度(2.96±1.84)mg/L;對照組血清IMA濃度(15.36±4.27)μg/L,hs-CRP濃度(1.86±0.97)mg/L;PDR組患者血清IMA濃度(54.72±15.61)μg/L,hs-CRP濃度(6.34±3.53)mg/L;NPDR組患者血清IMA濃度(38.35±11.27)μg/L,hs-CRP濃度(3.28±1.77)mg/L.DR組患者血清IMA和hs-CRP濃度明顯高于對照組和NDR組,NDR組患者血清IMA和hs-CRP濃度高于對照組,差異有統計學意義(F=197.124,34.561;q=5.41～27.34;P<0.01);PDR組患者血清IMA和hs-CRP濃度明顯高于NPDR患者組,差異有統計學意義(t=5.46,4.89;P<0.01);DR組患者血清IMA與hs-CRP濃度呈正相關(r=0.617,P<0.01).結論 DR患者血清IMA和hs-CRP濃度明顯升高,且與病情嚴重程度呈正相關,可能影響DR的髮展.
목적 탐토2형당뇨병병발시망막병변(DR)환자혈청결혈수식백단백(IMA)화초민C-반응단백(hs-CRP)농도적변화.방법 병례대조연구.채용매련면역흡부측정법화속솔산사비탁법검측79례DR조환자혈청IMA화hs-CRP농도변화,병여83례비DR(NDR)당뇨병조환자화72례대조조수검자진행비교,동시장40례증식성DR(PDR)조환자여39례비증식성DR(NPDR)조환자진행비교.채용PPMS 1.5통계학연건진행수거분석.량조균수비교채용t검험;다조균수비교채용단인소삼수평설계정량자료방차분석,다개균수지간량량비교채용q검험.결과 DR조환자혈청IMA농도(46.51±13.29)μg/L,hs-CRP농도(4.27±2.24)mg/L;NDR조환자혈청IMA농도(25.47±9.33)μg/L,hs-CRP농도(2.96±1.84)mg/L;대조조혈청IMA농도(15.36±4.27)μg/L,hs-CRP농도(1.86±0.97)mg/L;PDR조환자혈청IMA농도(54.72±15.61)μg/L,hs-CRP농도(6.34±3.53)mg/L;NPDR조환자혈청IMA농도(38.35±11.27)μg/L,hs-CRP농도(3.28±1.77)mg/L.DR조환자혈청IMA화hs-CRP농도명현고우대조조화NDR조,NDR조환자혈청IMA화hs-CRP농도고우대조조,차이유통계학의의(F=197.124,34.561;q=5.41～27.34;P<0.01);PDR조환자혈청IMA화hs-CRP농도명현고우NPDR환자조,차이유통계학의의(t=5.46,4.89;P<0.01);DR조환자혈청IMA여hs-CRP농도정정상관(r=0.617,P<0.01).결론 DR환자혈청IMA화hs-CRP농도명현승고,차여병정엄중정도정정상관,가능영향DR적발전.
Objective To explore the changes of the concentration of serum ischemia modified albumin(IMA) and high sensitivity C-reactive protein(hs-CRP) in type 2 diabetic patients with retinopathy (DR). Methods The concentration of serum IMA and hs-CRP in DR patients were determined by ELISA and ratenephetometry and compared with those in 83 no-DR (NDR) patients and 72 controls. The concentration of serum IMA and hs-CRP in 40 proliferative diabetic retinopathy (PDR) patients were compared with those in 39 no-PDR (NPDR) patients. Data was evaluated using analysis of PPMS version 1.5. Results are expressed as means ± standard deviation of the mean. Statistical comparisons were performed by student's t-test or one-way analysis of varrance followed by Dunnett's multiple comparison test and the means compared each other using q test. Results The serum IMA and hs-CRP concentration in DR patients were (46.51 ± 13.29) μg/L, (4.27 ±2.24) mg/L. The serum IMA and hs-CRP concentration in NDR patients were(25.47 ± 9. 33 ) μg/L, ( 2. 96± 1.84 ) mg/L. The serum IMA and hs-CRP concentration in controls were ( 15.36 ± 4.27 ) μg/L, ( 1.86 ±0. 97 ) mg/L. The serum IMA and hs-CRP concentration in PDR patients were(54. 72± 15.61 ) μg,/L, (6. 34 ± 3.53 ) mg/L. The serum IMA and hs-CRP concentration in NPDR patients were ( 38.35 ± 11.27 )μg/L, ( 3. 28 ± 1.77 ) mg/L. The serum IMA and hs-CRP concentration were significantly higher in DR patients than those in controls and NDR patients, the serum IMA and hs-CRP concentration in NDR patients were significantly higher than those in controls ( F = 197. 124,34. 561 ;q =5.41-27. 34;P <0. 01 ) ;the serum IMA and hs-CRP concentration were significantly higher in PDR patients than those in NPDR patients ( t = 5.46,4. 89 ;P < 0. 01 ) ;there was significant positive correlation between serum IMA concentration and hs-CRP concentration in DR patients( r =0. 617, P <0. 01 ). Conclusion The serum IMA and hs-CRP concentration were significantly high in DR patients, and were positively associated with the seriousness of DR, which may contribute to the development of DR.
