CAJ | 학술논문

目的总结分析缺血性视神经病变的发病特征、风险因素及预后,为该病的防治提供依据.方法回顾性系列病例研究.回顾性分析96例临床确诊的非动脉炎性前部缺血性视神经病变(NAION)患者的详尽临床资料,包括神经眼科检查及影像学、实验室检查.对基线特征、入院检查异常指标、视力恢复及视野损害进行均数、百分比等描述性特征的分析.结果患者平均发病年龄为(50.9±8.9)岁,年龄中位数50.0岁;男性占68.8%;患者中高血压、糖尿病和血脂异常的比例分别为34.4%(33/96)、29.2%(28/96)和59.4%(57/96);44.4%患者出院时视力提高≥3行.结论 NAION的发病年龄较低;男性比例高于女性;代谢综合征是常见的异常因素.脑白质病变、心肌缺血与NAION的关系密切.视野损害以水平及弓形缺损为主.NAION视力可有一定程度的恢复,但远期预后不良.加强早期干预是疾病防治重点.
목적 총결분석결혈성시신경병변적발병특정、풍험인소급예후,위해병적방치제공의거.방법 회고성계렬병례연구.회고성분석96례림상학진적비동맥염성전부결혈성시신경병변(NAION)환자적상진림상자료,포괄신경안과검사급영상학、실험실검사.대기선특정、입원검사이상지표、시력회복급시야손해진행균수、백분비등묘술성특정적분석.결과 환자평균발병년령위(50.9±8.9)세,년령중위수50.0세;남성점68.8%;환자중고혈압、당뇨병화혈지이상적비례분별위34.4%(33/96)、29.2%(28/96)화59.4%(57/96);44.4%환자출원시시력제고≥3행.결론 NAION적발병년령교저;남성비례고우녀성;대사종합정시상견적이상인소.뇌백질병변、심기결혈여NAION적관계밀절.시야손해이수평급궁형결손위주.NAION시력가유일정정도적회복,단원기예후불량.가강조기간예시질병방치중점.
Objective To evaluate the demographic,risk factors and clinical characteristics of nonarteritic anterior ischemic optic neuropathy (NAION) and provide clinical guidance for this blindness disease.Methods Retrospective study was used to investigate the data,which consists of 96 NAION consecutive patients in neurology department of our hospital from 2005 to 2008.Results The average age of NAION patients is 50.90±8.88 years (range,34-78 years) and the median is 50 y.About 68.8% of patients are male.The prevalence of hypertension,diabetes mellitus and abnormal lipid level is 34.4% (33/96),29.2% (21/96) and 59.4% (57/93) respectively.The predominant patterns of visual field loss are altitudinal and acurate defects.Visual acuity was improved (change of ≥3 lines) in 44.4% of patients.Conclusions The age of onset in NAION is relatively early in life,compared with cerebral vascular disease,and male seems to have a high incidence.The most common risk factor is metabolic syndrome.Subcortical and periventricular white matter lesions and myocardial ischemia might associate with NAION.Visual acuity showed improvement in some patients,but the long outcome is poor.