目的 探讨健康人眼的角膜光密度分布及其与眼内散射光的相关性.方法 前瞻性研究.采用随机数字表法选择进行常规眼科检查的健康人116例(232只眼),其中男55例(110只眼),女61例(122只眼),年龄为20 ～ 49岁,划分三个年龄段:20～29岁,30 ～ 39岁,40 ～ 49岁.利用Pentacam 三维眼前节分析诊断系统进行检查,以角膜顶点为中心,分别取≤2 mm、＞2mm且≤6 mm、＞ 6mm且≤10mm直径范围的角膜光密度平均值,以及2、6、10 mm直径虚拟圆的角膜厚度平均值,并使用C-quant散射光计量仪对人眼内的散射光进行定量测量.不同性别以及左右眼之间的角膜光密度比较采用独立样本t检验,不同年龄段的角膜光密度之间以及不同直径范围的角膜光密度之间比较采用单因素方差分析,不同直径范围的角膜光密度之间以及与年龄,角膜厚度,眼内散射光定量值之间的相关性研究采用Pearson相关分析.结果 ≤2 mm、＞2 mm且≤6 mm、＞6 mm且≤10 mm直径范围角膜光密度为10.1±1.5,9.3±1.3,9.6±1.7,范围8.2～ 16.7,7.9～ 14.2,7.3 ～ 16.2.＞6 mm且≤10 mm直径范围的角膜光密度在20 ～ 29岁、30 ～ 39岁、40 ～ 49岁年龄段分别为8.9±1.1,9.3±1.2,10.7±2.1,差异有统计学意义(F=28.939,P=0.000),＞6 mm且≤10 mm直径范围的角膜光密度与年龄之间存在明显的正相关关系(r =0.417,P=0.000),≤2 mm、＞2 mm且≤6 mm直径范围的角膜光密度在不同年龄段的统计值间均无统计学差异(F=1.575,1.436;P＞0.05),与年龄之间亦未发现相关性存在(r =0.002,0.048;P＞0.05).男性与女性相同直径范围的角膜光密度值之间不存在统计学差异(t=1.744,1.647,-1.181;P＞0.05).左右眼的角膜光密度值之间存在明显的相关性(r =0.977,0.992,0.933;P＜0.01),差异无统计学意义(t=0.124,0.199,-0.020;P＞0.05).＞6 mm且≤10 mm直径范围的角膜光密度值与≤2 mm及＞2 mm且≤6 mm直径范围的角膜光密度值之间呈正相关(r=0.710,P=0.000;r =0.748,P=0.000),≤2 mm直径范围与＞2 mm且≤6 mm直径范围的角膜光密度值呈正相关(r=0.973,P=0.000),相邻直径范围的角膜光密度存在更明显的相关关系,不同直径范围的角膜光密度之间存在显著性差异(F=17.057,P=0.000).眼内散射光定量值平均为0.95 ±0.19.≤2 mm、＞2 mm且≤6 mm、＞6 mm且≤10 mm直径范围的角膜光密度值与眼内散射光计量值均能呈正相关(r=0.134,0.146,0.159;P =0.042,0.026,0.016).结论 年龄对角膜光密度具有一定程度的影响,对周边角膜光密度的影响更大些.角膜光密度与角膜厚度之间无相关性.健康人眼的角膜光密度对眼内散射光存在一定的影响.
目的 探討健康人眼的角膜光密度分佈及其與眼內散射光的相關性.方法 前瞻性研究.採用隨機數字錶法選擇進行常規眼科檢查的健康人116例(232隻眼),其中男55例(110隻眼),女61例(122隻眼),年齡為20 ～ 49歲,劃分三箇年齡段:20～29歲,30 ～ 39歲,40 ～ 49歲.利用Pentacam 三維眼前節分析診斷繫統進行檢查,以角膜頂點為中心,分彆取≤2 mm、＞2mm且≤6 mm、＞ 6mm且≤10mm直徑範圍的角膜光密度平均值,以及2、6、10 mm直徑虛擬圓的角膜厚度平均值,併使用C-quant散射光計量儀對人眼內的散射光進行定量測量.不同性彆以及左右眼之間的角膜光密度比較採用獨立樣本t檢驗,不同年齡段的角膜光密度之間以及不同直徑範圍的角膜光密度之間比較採用單因素方差分析,不同直徑範圍的角膜光密度之間以及與年齡,角膜厚度,眼內散射光定量值之間的相關性研究採用Pearson相關分析.結果 ≤2 mm、＞2 mm且≤6 mm、＞6 mm且≤10 mm直徑範圍角膜光密度為10.1±1.5,9.3±1.3,9.6±1.7,範圍8.2～ 16.7,7.9～ 14.2,7.3 ～ 16.2.＞6 mm且≤10 mm直徑範圍的角膜光密度在20 ～ 29歲、30 ～ 39歲、40 ～ 49歲年齡段分彆為8.9±1.1,9.3±1.2,10.7±2.1,差異有統計學意義(F=28.939,P=0.000),＞6 mm且≤10 mm直徑範圍的角膜光密度與年齡之間存在明顯的正相關關繫(r =0.417,P=0.000),≤2 mm、＞2 mm且≤6 mm直徑範圍的角膜光密度在不同年齡段的統計值間均無統計學差異(F=1.575,1.436;P＞0.05),與年齡之間亦未髮現相關性存在(r =0.002,0.048;P＞0.05).男性與女性相同直徑範圍的角膜光密度值之間不存在統計學差異(t=1.744,1.647,-1.181;P＞0.05).左右眼的角膜光密度值之間存在明顯的相關性(r =0.977,0.992,0.933;P＜0.01),差異無統計學意義(t=0.124,0.199,-0.020;P＞0.05).＞6 mm且≤10 mm直徑範圍的角膜光密度值與≤2 mm及＞2 mm且≤6 mm直徑範圍的角膜光密度值之間呈正相關(r=0.710,P=0.000;r =0.748,P=0.000),≤2 mm直徑範圍與＞2 mm且≤6 mm直徑範圍的角膜光密度值呈正相關(r=0.973,P=0.000),相鄰直徑範圍的角膜光密度存在更明顯的相關關繫,不同直徑範圍的角膜光密度之間存在顯著性差異(F=17.057,P=0.000).眼內散射光定量值平均為0.95 ±0.19.≤2 mm、＞2 mm且≤6 mm、＞6 mm且≤10 mm直徑範圍的角膜光密度值與眼內散射光計量值均能呈正相關(r=0.134,0.146,0.159;P =0.042,0.026,0.016).結論 年齡對角膜光密度具有一定程度的影響,對週邊角膜光密度的影響更大些.角膜光密度與角膜厚度之間無相關性.健康人眼的角膜光密度對眼內散射光存在一定的影響.
목적 탐토건강인안적각막광밀도분포급기여안내산사광적상관성.방법 전첨성연구.채용수궤수자표법선택진행상규안과검사적건강인116례(232지안),기중남55례(110지안),녀61례(122지안),년령위20 ～ 49세,화분삼개년령단:20～29세,30 ～ 39세,40 ～ 49세.이용Pentacam 삼유안전절분석진단계통진행검사,이각막정점위중심,분별취≤2 mm、＞2mm차≤6 mm、＞ 6mm차≤10mm직경범위적각막광밀도평균치,이급2、6、10 mm직경허의원적각막후도평균치,병사용C-quant산사광계량의대인안내적산사광진행정량측량.불동성별이급좌우안지간적각막광밀도비교채용독립양본t검험,불동년령단적각막광밀도지간이급불동직경범위적각막광밀도지간비교채용단인소방차분석,불동직경범위적각막광밀도지간이급여년령,각막후도,안내산사광정량치지간적상관성연구채용Pearson상관분석.결과 ≤2 mm、＞2 mm차≤6 mm、＞6 mm차≤10 mm직경범위각막광밀도위10.1±1.5,9.3±1.3,9.6±1.7,범위8.2～ 16.7,7.9～ 14.2,7.3 ～ 16.2.＞6 mm차≤10 mm직경범위적각막광밀도재20 ～ 29세、30 ～ 39세、40 ～ 49세년령단분별위8.9±1.1,9.3±1.2,10.7±2.1,차이유통계학의의(F=28.939,P=0.000),＞6 mm차≤10 mm직경범위적각막광밀도여년령지간존재명현적정상관관계(r =0.417,P=0.000),≤2 mm、＞2 mm차≤6 mm직경범위적각막광밀도재불동년령단적통계치간균무통계학차이(F=1.575,1.436;P＞0.05),여년령지간역미발현상관성존재(r =0.002,0.048;P＞0.05).남성여녀성상동직경범위적각막광밀도치지간불존재통계학차이(t=1.744,1.647,-1.181;P＞0.05).좌우안적각막광밀도치지간존재명현적상관성(r =0.977,0.992,0.933;P＜0.01),차이무통계학의의(t=0.124,0.199,-0.020;P＞0.05).＞6 mm차≤10 mm직경범위적각막광밀도치여≤2 mm급＞2 mm차≤6 mm직경범위적각막광밀도치지간정정상관(r=0.710,P=0.000;r =0.748,P=0.000),≤2 mm직경범위여＞2 mm차≤6 mm직경범위적각막광밀도치정정상관(r=0.973,P=0.000),상린직경범위적각막광밀도존재경명현적상관관계,불동직경범위적각막광밀도지간존재현저성차이(F=17.057,P=0.000).안내산사광정량치평균위0.95 ±0.19.≤2 mm、＞2 mm차≤6 mm、＞6 mm차≤10 mm직경범위적각막광밀도치여안내산사광계량치균능정정상관(r=0.134,0.146,0.159;P =0.042,0.026,0.016).결론 년령대각막광밀도구유일정정도적영향,대주변각막광밀도적영향경대사.각막광밀도여각막후도지간무상관성.건강인안적각막광밀도대안내산사광존재일정적영향.
Objective To evaluate and investigate the distribution of corneal density and its Correlation with stray-light value in adult and healthy eyes.Methods A prospective study.Human corneal specimens ranging in age between 20 and 49 years,116 patients (232 eyes) in total,divided into three groups:20-29,30-39,40-49.Pentacam was used to evaluate total corneal average density and corneal thickness at different diameter around the corneal apex,for corneal density were ≤ 2 mm,＞ 2 mm and ≤6 mm,＞6 mm and ≤10 mm,for corneal thickness were 2 mm,6 mm and 10 mm,C-quant was used for the stray-light value.Software SPSS 17.0 was used for statistical analysis.Independent samples t testing mothed was applied to compare the corneal densitometry in different gender and between left eyes and right ones,One-way ANOVA was applied to analyze the differences of corneal density in different age groups and diameters.Pearson correlation analysis was applied to assess the correlation in corneal densitometry values of different diameters,between corneal density of different diameters and age,corneal density of different diameters and corneal thickness of different diameters,corneal density of different diameters and stray-light values.Results Corneal density for ≤2 mm,＞2 mm and ≤6 mm,＞6 mm and ≤10 mm diameter are 10.1±1.5(8.2-16.7),9.3±1.3(7.9-14.2),9.6±1.7(7.3-16.2).Corneal density of ＞6 mm and ≤10 mm diameter in different age groups were 8.9± 1.1,9.3 ± 1.2,10.7±2.1,there was a statistical difference in these values(F =28.939,P =0.000),and there was a positive correlation between corneal density of ＞ 6 mm and ≤ 10 mm diameter and age (r =0.417,P =0.000),There were no statistical differences in corneal density values of ≤ 2 mm and ＞ 2 mm and ≤ 6 mm in different age groups (F =1.575,1.436 ; P ＞ 0.05),and they had no correlation with age (r =0.002,0.048 ; P ＞ 0.05).There was no statistical difference in corneal density in different gender (t =1.744,1.647,-1.181 ; P ＞ 0.05).Corneal density values of left eyes and right ones had positive relationships at the same diameter (r =0.977,P =0.000;r =0.992,P =0.000;r =0.933,P =0.000),and there were no statistical differences (t =0.124,0.199,-0.020;P ＞ 0.05).Between corneal density values of different diameter,there are also some positive relationships,＞6 mm and ≤10 mm and ≤2 mm (r =0.710,P =0.000),＞6 mm and ≤10 mm and ＞2 mmand ≤6mm (r=0.748,P=0.000),≤2 mm and ＞2 mm and ≤6 mm (r=0.973,P=0.000),relationship between ≤2 mm and ＞2 mm and ≤6 mm,＞2 mm and ≤6 mm and ＞6 mm and ≤10 mm was obvious,and there was statistical difference in them (F =17.057,P =0.000).The ocular straylight value was 0.95 ±0.19(0.48-1.38),Corneal density values of ≤2 mm,＞2 mm and ≤6 mm and ＞ 6 mm and ≤ 10 mm diameter had positive relationships with the straylight value (r =0.134,0.146,0.159,P =0.042,0.026,0.016).Conclusions Corneal density can be influenced by age,the influence from age infected the corneal density of peripheral more.There was no correlation between corneal density and corneal thickness.There were some influences of corneal density of healthy eyes to the ocular straylight.
