CAJ | 학술논문

目的综合评价高同型半胱氮酸血症与多发性硬化的关系.方法全面检索Cochrane、Medline、EMbase、Springerlink、Highwire、CBM、CNKI、维普和万方等中英文数据库,获得有关同型半胱氨酸与多发性硬化关系的研究结果,对其进行方法学质量评价、筛选和异质性检验,要求所纳入文献的设计均为病例对照研究.采用Stats 8.0软件对提取的数据进行分析.结果有9篇文献进入Meta分析,共获得1146例样本,其中病例组676例,对照组470例.Meta分析结果显示,MS组血浆同型半胱氨酸水平显著高于对照组(标准化均差为1.25,95%可信区间为0.48～2.01).敏感性分析显示两组在血浆同型半胱氨酸水平上的差异结果可靠.结论高同型半胱氨酸血症与MS具有相关性,它可能在MS的病理过程中起一定作用.
목적 종합평개고동형반광담산혈증여다발성경화적관계.방법 전면검색Cochrane、Medline、EMbase、Springerlink、Highwire、CBM、CNKI、유보화만방등중영문수거고,획득유관동형반광안산여다발성경화관계적연구결과,대기진행방법학질량평개、사선화이질성검험,요구소납입문헌적설계균위병례대조연구.채용Stats 8.0연건대제취적수거진행분석.결과 유9편문헌진입Meta분석,공획득1146례양본,기중병례조676례,대조조470례.Meta분석결과현시,MS조혈장동형반광안산수평현저고우대조조(표준화균차위1.25,95%가신구간위0.48～2.01).민감성분석현시량조재혈장동형반광안산수평상적차이결과가고.결론 고동형반광안산혈증여MS구유상관성,타가능재MS적병리과정중기일정작용.
Objective To determine the relationship between hyperhomocysteinemia and multiple sclerosis (MS). Methods Cochrane, Medline, EMbase, Springerlink, Highwire, CBM, CNKI and some other databases were searched for literatures. Articles were identified using the Medical Subject Heading term "hyperhomocysteinemia, homocysteine, multiple sclerosis". The methodological quality of internalized literatures were valuated, screened and heterogeneity tested. Case control studies involving unrelated subjects and valid data were extracted and analyzed in Stata 8.0. Results Nine studies were included in this review. The involved 1146 subjects were made of 676 patients and 470 controls. A meta-analysis showed that the level of homocysteine in MS was higher than that in controls (standardized mean difference 1.25, 95% CI:0.48-2.01). The analytical result of sensitivity proved that the result of meta-analysis was coherent. Conclusion Hyperhomocysteinemia is associated with MS, and it may contribute tu the pathological course of MS.