CAJ | 학술논문

术后妊娠对年轻乳腺癌患者预后的影响
술후임신대년경유선암환자예후적영향
Effect of postoperative pregnancy upon prognosis of young breast cancer patients

万方数据

中华医学杂志中華醫學雜誌 중화의학잡지
National Medical Journal of China
2009年 44期 3126-3129 ,共4页

吴佳毅%陈灿铭%张家新%侯意枫%胡震%柳光宇%狄根红%吴炅%陆劲松%沈坤炜%邵志敏%沈镇宙

오가의%진찬명%장가신%후의풍%호진%류광우%적근홍%오경%륙경송%침곤위%소지민%침진주

乳腺肿瘤%妊娠%预后%年轻乳腺腫瘤%妊娠%預後%年輕
유선종류%임신%예후%년경
Breast neoplasms%Pregnancy%Prognosis%Young

目的评估术后妊娠对中国年轻女性乳腺癌患者预后的影响.方法对1989年3月至2007年7月于我院治疗的432例年轻(≤35岁)单侧乳腺癌患者进行回顾性研究,分析术后妊娠对预后的影响,用Kaplan-Meier法进行生存分析,Log Rank法比较不同患者的生存差异,用Cox回归分析对患者进行多因素回归分析.结果 432例年轻乳腺癌患者中共有18例术后妊娠,其中5例足月产,13例流产,最早妊娠的时间为术后17个月.中位随访62个月(6～237个月),432例患者的无病生存率(DFS)为72.5%(313/432),总体生存率(OS)为88.7%(383/432).Cox回归多因素分析发现术后妊娠、临床分期及病理腋窝淋巴结转移数对患者的DFS有显著影响,只有淋巴结转移数对患者的OS有显著影响.由于术后妊娠的患者中并未出现死亡,Cox回归分析中术后妊娠对预后并无显著影响.结论年轻乳腺癌患者手术后妊娠对预后无不良影响.
목적 평고술후임신대중국년경녀성유선암환자예후적영향.방법 대1989년3월지2007년7월우아원치료적432례년경(≤35세)단측유선암환자진행회고성연구,분석술후임신대예후적영향,용Kaplan-Meier법진행생존분석,Log Rank법비교불동환자적생존차이,용Cox회귀분석대환자진행다인소회귀분석.결과 432례년경유선암환자중공유18례술후임신,기중5례족월산,13례유산,최조임신적시간위술후17개월.중위수방62개월(6～237개월),432례환자적무병생존솔(DFS)위72.5%(313/432),총체생존솔(OS)위88.7%(383/432).Cox회귀다인소분석발현술후임신、림상분기급병리액와림파결전이수대환자적DFS유현저영향,지유림파결전이수대환자적OS유현저영향.유우술후임신적환자중병미출현사망,Cox회귀분석중술후임신대예후병무현저영향.결론 년경유선암환자수술후임신대예후무불량영향.
Objective To examine the effect of postoperative pregnancy upon the prognosis of young Chinese breast cancer patients. Methods Four hundred and thirty-two female unilateral breast cancer patients aged 35 or younger were retrospectively reviewed. Kaplan-Meier analysis and Log Rank test were used for univariate analysis of factors predictive of disease-free survival (DFS) and overall survival (OS). Multivariate analysis was carried out using the Cox proportional hazards model. Results Eighteen patients were identified to have postoperative pregnancy, including 5 full-term pregnancy and 13 abortions with the earliest pregnancy taking place at Month 17 post-operation. After a median follow-up of 62 months (6-237 months), the DFS and OS rates were 72. 5% (313/432) and 88. 7% (383/432) respectively. On multivariate analysis, postoperative pregnancy, clinical stage and number of pathologically involved axillary lymph node were significantly associated with DFS. And the axillary lymph node status was also predictive of OS. No death occurred in patient with postoperative pregnancy. There was no significant association between postoperative pregnancy and OS. Conclusion Postoperative pregnancy has no adverse effect upon the prognosis of young breast cancer patients.