中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2011年
29期
2038-2041
,共4页
瓦热斯江·衣不拉音%陈照丽%谭锋维%孙楠%赫捷
瓦熱斯江·衣不拉音%陳照麗%譚鋒維%孫楠%赫捷
와열사강·의불랍음%진조려%담봉유%손남%혁첩
食管肿瘤%Rho相关的蛋白激酶2%细胞分化
食管腫瘤%Rho相關的蛋白激酶2%細胞分化
식관종류%Rho상관적단백격매2%세포분화
Esophageal neoplasms%ROCK2 protein%Cell differentiation
目的 研究Rho相关的蛋白激酶2(ROCK2)在食管鳞癌组织中的表达水平及其临床意义.方法 收集1990至2001年间在中国医学科学院肿瘤医院接受手术治疗的原发食管癌病例,免疫组织化学方法检测了组织芯片中118例食管鳞癌组织及其配对的癌旁正常食管黏膜中ROCK2的表达水平.将病例按年龄、性别、肿瘤部位、吸烟与否、分化程度、T分期、淋巴结转移及TNM分期进行分组,比较不同组别中ROCK2表达水平的差异.结果 ROCK2在118例食管鳞癌组织中的高表达率为45.76%(54/118).在年龄＜61岁组,ROCK2高表达率为55.74%(34/61),高于年龄＞6l岁组的35.09%(20/57),两者差异具有统计学意义(x2=5.062,P=0.024).高分化病例组中ROCK2高表达率为58.70%(27/46),高于中、低分化病例组的37.50%(27/22),差异具有统计学意义(x2=5.080,P=0.024).结论 ROCK2在食管鳞癌组织中的表达升高与发病年龄及肿瘤的分化程度相关.
目的 研究Rho相關的蛋白激酶2(ROCK2)在食管鱗癌組織中的錶達水平及其臨床意義.方法 收集1990至2001年間在中國醫學科學院腫瘤醫院接受手術治療的原髮食管癌病例,免疫組織化學方法檢測瞭組織芯片中118例食管鱗癌組織及其配對的癌徬正常食管黏膜中ROCK2的錶達水平.將病例按年齡、性彆、腫瘤部位、吸煙與否、分化程度、T分期、淋巴結轉移及TNM分期進行分組,比較不同組彆中ROCK2錶達水平的差異.結果 ROCK2在118例食管鱗癌組織中的高錶達率為45.76%(54/118).在年齡＜61歲組,ROCK2高錶達率為55.74%(34/61),高于年齡＞6l歲組的35.09%(20/57),兩者差異具有統計學意義(x2=5.062,P=0.024).高分化病例組中ROCK2高錶達率為58.70%(27/46),高于中、低分化病例組的37.50%(27/22),差異具有統計學意義(x2=5.080,P=0.024).結論 ROCK2在食管鱗癌組織中的錶達升高與髮病年齡及腫瘤的分化程度相關.
목적 연구Rho상관적단백격매2(ROCK2)재식관린암조직중적표체수평급기림상의의.방법 수집1990지2001년간재중국의학과학원종류의원접수수술치료적원발식관암병례,면역조직화학방법검측료조직심편중118례식관린암조직급기배대적암방정상식관점막중ROCK2적표체수평.장병례안년령、성별、종류부위、흡연여부、분화정도、T분기、림파결전이급TNM분기진행분조,비교불동조별중ROCK2표체수평적차이.결과 ROCK2재118례식관린암조직중적고표체솔위45.76%(54/118).재년령＜61세조,ROCK2고표체솔위55.74%(34/61),고우년령＞6l세조적35.09%(20/57),량자차이구유통계학의의(x2=5.062,P=0.024).고분화병례조중ROCK2고표체솔위58.70%(27/46),고우중、저분화병례조적37.50%(27/22),차이구유통계학의의(x2=5.080,P=0.024).결론 ROCK2재식관린암조직중적표체승고여발병년령급종류적분화정도상관.
Objective To investigate the expression and relationship of Rho-associated protein kinase 2 (ROCK2) and clinical characteristics in esophageal squamous cell carcinoma (ESCC). Methods Immunohistochemistry was performed to assay the expression of ROCK2 in tumor tissues and adjacent normal epithelium from 118 ESCC patients in tissue microarray. The relationship between ROCK2 level and clinicopathologic profiles such as age, gender, location, smoking, differentiation degree, T stage, lymph node metastasis and TNM stage were analyzed. Results The ROCK2 expression was up-regulated in 54 of 118 (45. 76% ) ESCC tissues. The up-regulated expression of ROCK2 was observed in 55.74% (34/61) ESCC tissues of patients under 61 years old. And it was significantly higher than that in 35.09% (20/57) of patients over 61 years old ( x2 = 5.062, P = 0. 024 ). In addition, the rate of up-regulation of ROCK2 was significantly higher in high-grade differentiation group (58. 70%, 27/46 ) than that in moderate-grade and low-grade differentiation group ( 37.50%, 27/72 ) ( x2 = 5.080, P = 0. 024 ). Conclusion The upregulated expression of ROCK2 is correlated with patient age and differentiation grade of ESCC.
