CAJ | 학술논문

目的综合评价亚甲基四氢叶酸还原酶(MTHFR)基因多态性与缺血性脑卒中(IS)在不同种族间的关系.方法电子检索MEDLINE、EMBASE、Cochrane Library等数据库,查找已发表的相关文献.采用荟萃分析方法,对17篇关于MTHFR基因多态性与缺血性脑卒中关系的研究文献进行综合定量分析.结果荟萃分析表明,携带MTHFR基因TT基因型发生缺血性脑卒中的危险性是非TT基因型的1.30倍,95%CI为1.11～1.52.携带MTHFR基因CC基因型发生缺血性脑卒中的危险性是非CC基因型的0.88倍,95%CI为0.79～0.98.亚组分析显示MTHFR基因发生缺血性脑卒中的危险性因种族而异,高加索人群更易于发生缺血性脑卒中.结论 MTHFR基因C677T多态性与高加索人缺血性脑卒中的易感性密切相关,与蒙古人及其他人种缺血性脑卒中的关系需进一步研究讨论.
목적 종합평개아갑기사경협산환원매(MTHFR)기인다태성여결혈성뇌졸중(IS)재불동충족간적관계.방법 전자검색MEDLINE、EMBASE、Cochrane Library등수거고,사조이발표적상관문헌.채용회췌분석방법,대17편관우MTHFR기인다태성여결혈성뇌졸중관계적연구문헌진행종합정량분석.결과 회췌분석표명,휴대MTHFR기인TT기인형발생결혈성뇌졸중적위험성시비TT기인형적1.30배,95%CI위1.11～1.52.휴대MTHFR기인CC기인형발생결혈성뇌졸중적위험성시비CC기인형적0.88배,95%CI위0.79～0.98.아조분석현시MTHFR기인발생결혈성뇌졸중적위험성인충족이이,고가색인군경역우발생결혈성뇌졸중.결론 MTHFR기인C677T다태성여고가색인결혈성뇌졸중적역감성밀절상관,여몽고인급기타인충결혈성뇌졸중적관계수진일보연구토론.
Objective To evaluate the relationship between the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and the susceptibility of ischemic stroke among different ethnic populations.Methods The databases of MEDLINE, EMBASE, Cochrane Library and others were searched. And a total of 17 studies published in English between 2000 and October 2010 on the association of MTHFR gene C677T polymorphism with ischemic stroke were selected. A comprehensive quantitative analysis was performed by meta-analysis. Results The results showed that the pooled OR values of ischemic stroke with TT and CC genotype were 1.30 (95% CI: 1.11 to 1.52) and 0. 88 (95% CI: 0. 79 to 0. 98 ) respectively. And when sub-grouped by ethnic populations, the Caucasians were more likely than other populations to suffer ischemic stroke. There was a low probability of publication bias. Conclusion The presence of MTHFR TT gene is associated with an elevated risk of developing ischemic stroke, especially in Caucasians.