中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2011年
47期
3371-3373
,共3页
纪建松%傅红兴%宋晶晶%李慧%朱雁林
紀建鬆%傅紅興%宋晶晶%李慧%硃雁林
기건송%부홍흥%송정정%리혜%주안림
表柔比星%葡甲胺%复方
錶柔比星%葡甲胺%複方
표유비성%포갑알%복방
Epirubicin%Meglumine%Compounds
目的 制备复方盐酸表柔比星聚乳酸-羟基乙酸共聚物( PLGA)纳米粒,并对其含量进行测定.方法 采用乳化-溶剂挥发法制备复方盐酸表柔比星纳米粒,添加适量乳糖后采用冷冻干燥法制备得到复方盐酸表柔比星纳米粒冻干粉,通过反相高效液相法测定盐酸表柔比星和钆喷酸双葡甲胺的含量和释放度.结果 制备得到复方盐酸表柔比星PLGA纳米粒,初步建立了可同时测定两种药物成分的高效液相含量测定方法,复方制剂中盐酸表柔比星和钆喷酸双葡甲胺的含量分别为100.6%±1.6%、99.1%±1.9%,且两种成分均能在9d内释放完全.结论 本方法制备复方盐酸表柔比星PLGA纳米粒简便可行,所拟定的含量测定方法可行.
目的 製備複方鹽痠錶柔比星聚乳痠-羥基乙痠共聚物( PLGA)納米粒,併對其含量進行測定.方法 採用乳化-溶劑揮髮法製備複方鹽痠錶柔比星納米粒,添加適量乳糖後採用冷凍榦燥法製備得到複方鹽痠錶柔比星納米粒凍榦粉,通過反相高效液相法測定鹽痠錶柔比星和釓噴痠雙葡甲胺的含量和釋放度.結果 製備得到複方鹽痠錶柔比星PLGA納米粒,初步建立瞭可同時測定兩種藥物成分的高效液相含量測定方法,複方製劑中鹽痠錶柔比星和釓噴痠雙葡甲胺的含量分彆為100.6%±1.6%、99.1%±1.9%,且兩種成分均能在9d內釋放完全.結論 本方法製備複方鹽痠錶柔比星PLGA納米粒簡便可行,所擬定的含量測定方法可行.
목적 제비복방염산표유비성취유산-간기을산공취물( PLGA)납미립,병대기함량진행측정.방법 채용유화-용제휘발법제비복방염산표유비성납미립,첨가괄량유당후채용냉동간조법제비득도복방염산표유비성납미립동간분,통과반상고효액상법측정염산표유비성화구분산쌍포갑알적함량화석방도.결과 제비득도복방염산표유비성PLGA납미립,초보건립료가동시측정량충약물성분적고효액상함량측정방법,복방제제중염산표유비성화구분산쌍포갑알적함량분별위100.6%±1.6%、99.1%±1.9%,차량충성분균능재9d내석방완전.결론 본방법제비복방염산표유비성PLGA납미립간편가행,소의정적함량측정방법가행.
Objective To prepare compound epirubicin hydrochloride-loaded polymeric nanoparticles of L-lactic-co-glycolic acid and establish their quality control.Methods The emulsion-solvent evaporation method was employed to prepare and freeze-dry the compound epirubicin hydrochloride-loaded polymeric nanoparticles of L-lactic-co-glycolic acid after the addition of lactose.The contents and cumulative release of epirubicin hydrochloride and dimeglumine gadopentetate were detected simultaneously by RPHPLC (reverse phase-high performance liquid chromatography).Results The above nanoparticles were prepared and the quality standards for simultaneously determining the contents of epirubicin hydrochloride and dimeglumine gadopentetate established primarily.The contents of epirubicin hydrochloride and dimeglumine gadopentetate in compound preparation were 100.6% ± 1.6% and 99.1% ± 1.9%respectively.And two compositions could be completely released within 9 days.Conclusion The preparation method of nanoparticles is simple and their quality control feasible.