中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2011年
48期
3431-3434
,共4页
吴婵%董方田%于伟泓%戴荣平%楼慧萍%张峣
吳嬋%董方田%于偉泓%戴榮平%樓慧萍%張峣
오선%동방전%우위홍%대영평%루혜평%장요
视网膜%动脉硬化%肾功能损害%相关性%危险因素
視網膜%動脈硬化%腎功能損害%相關性%危險因素
시망막%동맥경화%신공능손해%상관성%위험인소
Retina%Atherosclerosis%Renal dysfunction%Correlation%Risk factor
目的 分析参加健康体检的北京城市人群中视网膜动脉硬化与肾功能损害的相关性并比较两种疾病的危险因素.方法 回顾性分析2010年6月至2011年2月间在我院健康体检中40岁以上非糖尿病人群中视网膜动脉硬化及肾功能损害的资料,采用Pearson线性相关分析评估视网膜动脉硬化和肾功能损害的相关性,通过多因素Logistic回归模型比较两种疾病的危险因素.结果 研究期间共有10 191名体检者纳入分析,诊断视网膜动脉硬化1287例(12.6％),诊断肾功能损害434例(4.3％).同时诊断两种疾病者占1.0％,仅诊断视网膜动脉硬化者占12.2％,仅诊断肾功能损害者占3.3％.两种疾病间的相关系数r =0.21(P ＜0.01).在多因素Logistic回归分析中,肥胖(OR =2.5,95％CI2.0 ～3.2)、高血压(OR=2.2,95％CI2.0～2.6)是对于视网膜动脉硬化相对危险度最高的因素,而年龄(OR =3.1,95％ CI2.8 ～3.5)则是对于肾功能损害的主要因素.结论 视网膜动脉硬化和肾功能损害的低相关性及危险因素不同分布说明两种疾病在发病机制方面可能存在一定的差异,应采取不同的防治策略.
目的 分析參加健康體檢的北京城市人群中視網膜動脈硬化與腎功能損害的相關性併比較兩種疾病的危險因素.方法 迴顧性分析2010年6月至2011年2月間在我院健康體檢中40歲以上非糖尿病人群中視網膜動脈硬化及腎功能損害的資料,採用Pearson線性相關分析評估視網膜動脈硬化和腎功能損害的相關性,通過多因素Logistic迴歸模型比較兩種疾病的危險因素.結果 研究期間共有10 191名體檢者納入分析,診斷視網膜動脈硬化1287例(12.6％),診斷腎功能損害434例(4.3％).同時診斷兩種疾病者佔1.0％,僅診斷視網膜動脈硬化者佔12.2％,僅診斷腎功能損害者佔3.3％.兩種疾病間的相關繫數r =0.21(P ＜0.01).在多因素Logistic迴歸分析中,肥胖(OR =2.5,95％CI2.0 ～3.2)、高血壓(OR=2.2,95％CI2.0～2.6)是對于視網膜動脈硬化相對危險度最高的因素,而年齡(OR =3.1,95％ CI2.8 ～3.5)則是對于腎功能損害的主要因素.結論 視網膜動脈硬化和腎功能損害的低相關性及危險因素不同分佈說明兩種疾病在髮病機製方麵可能存在一定的差異,應採取不同的防治策略.
목적 분석삼가건강체검적북경성시인군중시망막동맥경화여신공능손해적상관성병비교량충질병적위험인소.방법 회고성분석2010년6월지2011년2월간재아원건강체검중40세이상비당뇨병인군중시망막동맥경화급신공능손해적자료,채용Pearson선성상관분석평고시망막동맥경화화신공능손해적상관성,통과다인소Logistic회귀모형비교량충질병적위험인소.결과 연구기간공유10 191명체검자납입분석,진단시망막동맥경화1287례(12.6％),진단신공능손해434례(4.3％).동시진단량충질병자점1.0％,부진단시망막동맥경화자점12.2％,부진단신공능손해자점3.3％.량충질병간적상관계수r =0.21(P ＜0.01).재다인소Logistic회귀분석중,비반(OR =2.5,95％CI2.0 ～3.2)、고혈압(OR=2.2,95％CI2.0～2.6)시대우시망막동맥경화상대위험도최고적인소,이년령(OR =3.1,95％ CI2.8 ～3.5)칙시대우신공능손해적주요인소.결론 시망막동맥경화화신공능손해적저상관성급위험인소불동분포설명량충질병재발병궤제방면가능존재일정적차이,응채취불동적방치책략.
Objective To evaluate the correlation between retinal artery atherosclerosis and renal dysfunction and compare their risk factors in an urban population of Beijing.Methods The non-diabetic adults ＞40 years old undergoing annual physical examinations during June 2010 and February 2011 at one medical center were evaluated.Pearson correlation coefficient was calculated between retinal artery atherosclerosis and renal dysfunction.The analyses of multivariate Logistic regression were performed to compare the risk factors of these two diseases.Results Among 10 191 subjects included,retinal artery atherosclerosis was diagnosed in 1287 ( 12.6％ ) and renal dysfunction in 434 (4.3％ ). And 1.0％ of subjects had both two diseases versus 12.2％ with retinal artery atherosclerosis alone and 3.3％ with renal dysfunction alone.Correlation coefficient was low between two diseases (r =0.21 ; P ＜ 0.01 ).According to the analyses of multivariate Logistic regression,the strongest predictors of retinal artery atherosclerosis were obesity (OR=2.5,95％CI 2.0-3.2) and hypertension (OR=2.2,95％CI 2.0-2.6) while advanced age (OR =3.1,95％ CI 2.8 - 3.5 per 10 year increment ) was the strongest factor for renal dysfunction.Conclusion The low-level correlation and different risk factor profiles between retinal artery atherosclerosis and renal dysfunction indicate different pathogenic mechanisms of two diseases and suggest different preventive strategies.
