CAJ | 학술논문

目的分析精神分裂症患者健康同胞的脑弥散张量成像.方法所有受试者于2009年11月至2012年3月入组,来源于广告招募.20名在中山大学附属第三医院精神科住院的精神分裂症患者的健康同胞和45名无精神障碍家族史的健康对照接受脑磁共振弥散张量成像.应用DTIstudio和SPM5软件包以基于体素的分析方法对两组图像进行预处理,然后对所得各向异性分数(FA)图像进行两独立样本t检验.结果 (1)精神分裂症患者健康同胞组右侧前扣带(MNI:x=9,y =43,z=4；体素集合数=106)白质FA值低于健康对照组.(2)精神分裂症患者健康同胞组无脑白质FA值高于健康对照组的脑区.结论右侧前扣带白质完整性下降可能是精神分裂症发病的风险因素.
목적 분석정신분렬증환자건강동포적뇌미산장량성상.방법 소유수시자우2009년11월지2012년3월입조,래원우엄고초모.20명재중산대학부속제삼의원정신과주원적정신분렬증환자적건강동포화45명무정신장애가족사적건강대조접수뇌자공진미산장량성상.응용DTIstudio화SPM5연건포이기우체소적분석방법대량조도상진행예처리,연후대소득각향이성분수(FA)도상진행량독립양본t검험.결과 (1)정신분렬증환자건강동포조우측전구대(MNI:x=9,y =43,z=4；체소집합수=106)백질FA치저우건강대조조.(2)정신분렬증환자건강동포조무뇌백질FA치고우건강대조조적뇌구.결론 우측전구대백질완정성하강가능시정신분렬증발병적풍험인소.
Objective To explore the diffusion tensor imaging (DTI) features of white matter in healthy siblings of schizophrenics. Methods Twenty healthy siblings of schizophrenics and 45 healthy controls without a family history of mental disorder. They responded to advertised recruitment during December 2009 and March 2012. All participants underwent diffusion weighted magnetic resonance images with a single-shot echo planar imaging (EPI)sequence aligned to straight axial plane. The fractional anisotropy (FA)images of two groups underwent two-sample t-test with SPM5 software. Results The healthy siblings of schizophrenics demonstrated a significant decrease of regional white matter FA values in right anterior cingulated (MNI:x =9, y = 43,z = 4;cluster = 106) . Conclusion Reduced white matter integrity in right anterior cingulated may be a risk actor of schizophrenia.