CAJ | 학술논문

目的探讨局部晚期鼻咽癌生物加量靶区(BBTV)的检测定义方法.方法回顾分析2010年9至12月中山大学肿瘤防治中心收治的局部晚期鼻咽癌患者10例,综合常规照射中原发肿瘤体积的颅底欠量区、照射36 Gy后99mTc-HL91 SPET/CT显像乏氧区和同一治疗体位CT图像对比评估肿瘤负荷区来勾画BBTV.结果 BBTV体积为(17 ±7)cm3,占原发肿瘤体积的51％±19％;颅底欠量区、乏氧区和肿瘤负荷区的体积与其占BBTV体积百分比分别为(5.8±2.5)cm3、(7.7±3.6)cm3、(9.0±5.8)cm3和34.4％、45.7％、53.3％,交叠体积仅占BBTV的33.1％.结论局部晚期鼻咽癌由颅底欠量区、照射36 Gy时的乏氧区和肿瘤负荷区整合组成BBTV是可考虑的,BBTV的建立为实施个体化放疗提供了新的参考.
목적 탐토국부만기비인암생물가량파구(BBTV)적검측정의방법.방법 회고분석2010년9지12월중산대학종류방치중심수치적국부만기비인암환자10례,종합상규조사중원발종류체적적로저흠량구、조사36 Gy후99mTc-HL91 SPET/CT현상핍양구화동일치료체위CT도상대비평고종류부하구래구화BBTV.결과 BBTV체적위(17 ±7)cm3,점원발종류체적적51％±19％;로저흠량구、핍양구화종류부하구적체적여기점BBTV체적백분비분별위(5.8±2.5)cm3、(7.7±3.6)cm3、(9.0±5.8)cm3화34.4％、45.7％、53.3％,교첩체적부점BBTV적33.1％.결론 국부만기비인암유로저흠량구、조사36 Gy시적핍양구화종류부하구정합조성BBTV시가고필적,BBTV적건립위실시개체화방료제공료신적삼고.
Objective To explore the methods of detecting and defining the biological boosting target volume(BBTV)in patients with locally advanced nasopharyngeal carcinoma(NPC).Methods Ten patients with locally advanced NPC treated at our center during September to December 2010 were enrolled.The following factors were used to define and contour BBTV,including dose-deficient area locating at skull-base of gross tumor volume in conventional irradiation,hypoxia area detected by 99mTc-HL91 Single-photon emission computed tomography/computed tomography(SPET/CT)imaging and tumor-burdened area evaluated by comparing the pre-treatment and 36 Gy irradiation's CT images scanning at the same treatment position.Results The volume of BBTV was(17 ± 7)cm3,accounting for 51％ ± 19％ of gross tumor volume.In BBTV,the volumes and proportion of skull base dose-deficient,hypoxia and tumor-burdened area were(5.8 ± 2.5)cm3,(7.7 ± 3.6)cm3,(9.0 ± 5.8)cm3 and 34.4％,45.7％ and 53.3％respectively.However,the proportion of overlapping volume between three areas was only 33.1％.Conclusion BBTV may be composed of skull base dose-deficient,hypoxia and tumor-burdened volume.It provides a new reference for individualized radiotherapy in locally advanced NPC.