中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2013年
2期
135-137
,共3页
甲状旁腺功能减退症%肌酸激酶%钙%肌酶
甲狀徬腺功能減退癥%肌痠激酶%鈣%肌酶
갑상방선공능감퇴증%기산격매%개%기매
Hypoparathyroidism%Creatine kinase%Calcium%Muscle enzyme
目的 探讨甲状旁腺功能减退症(HP)伴肌酶改变的临床资料及与年龄、性别、病程、血清总钙、总磷、甲状旁腺激素(PTH)的关系.方法 对2005年1月至2011年10月郑州大学第一附属医院内分泌科收治的HP患者41例病历资料进行回顾性分析.结果 41例HP中16例伴肌酶增高,25例肌酶正常.16例肌酶增高患者中特发性HP(IHP)11例,假性HP (PHP)5例；血钙(1.53±0.25) mmol/L,血磷(2.1±0.6)mmol/L,血清肌酸激酶(CK)、乳酸脱氢酶(LDH)、天冬氨酸转氨酶(AST)分别为309(126 ～10 046)U/L、279(131 ～741) U/L、27(17 ～ 467) U/L.25例肌酶正常患者中IHP 20例,PHP 5例；血钙(1.64±0.29) mmol/L,血磷(2.2±0.6)mmol/L; CK(124±45) U/L,LDH(189 ±22) U/L,AST(25.6 ±7.3)U/L.16例HP肌酶增高患者治疗前后肌酶进行比较,肌酶水平均随血钙浓度的升高明显降低.HP患者的CK(r=-0.82)、LDH(r=-0.55)、AST(r=-0.56)的增高与血钙浓度呈负相关(均P＜0.05)；与年龄、性别、病程、血清磷、PTH均无相关性(P＞0.05).结论 HP患者的肌酶增高与血清钙呈负相关,与年龄、性别、病程、血清磷、PTH均无相关性；且各种酶学的变化随着血钙水平的正常而逐渐恢复.
目的 探討甲狀徬腺功能減退癥(HP)伴肌酶改變的臨床資料及與年齡、性彆、病程、血清總鈣、總燐、甲狀徬腺激素(PTH)的關繫.方法 對2005年1月至2011年10月鄭州大學第一附屬醫院內分泌科收治的HP患者41例病歷資料進行迴顧性分析.結果 41例HP中16例伴肌酶增高,25例肌酶正常.16例肌酶增高患者中特髮性HP(IHP)11例,假性HP (PHP)5例；血鈣(1.53±0.25) mmol/L,血燐(2.1±0.6)mmol/L,血清肌痠激酶(CK)、乳痠脫氫酶(LDH)、天鼕氨痠轉氨酶(AST)分彆為309(126 ～10 046)U/L、279(131 ～741) U/L、27(17 ～ 467) U/L.25例肌酶正常患者中IHP 20例,PHP 5例；血鈣(1.64±0.29) mmol/L,血燐(2.2±0.6)mmol/L; CK(124±45) U/L,LDH(189 ±22) U/L,AST(25.6 ±7.3)U/L.16例HP肌酶增高患者治療前後肌酶進行比較,肌酶水平均隨血鈣濃度的升高明顯降低.HP患者的CK(r=-0.82)、LDH(r=-0.55)、AST(r=-0.56)的增高與血鈣濃度呈負相關(均P＜0.05)；與年齡、性彆、病程、血清燐、PTH均無相關性(P＞0.05).結論 HP患者的肌酶增高與血清鈣呈負相關,與年齡、性彆、病程、血清燐、PTH均無相關性；且各種酶學的變化隨著血鈣水平的正常而逐漸恢複.
목적 탐토갑상방선공능감퇴증(HP)반기매개변적림상자료급여년령、성별、병정、혈청총개、총린、갑상방선격소(PTH)적관계.방법 대2005년1월지2011년10월정주대학제일부속의원내분비과수치적HP환자41례병력자료진행회고성분석.결과 41례HP중16례반기매증고,25례기매정상.16례기매증고환자중특발성HP(IHP)11례,가성HP (PHP)5례；혈개(1.53±0.25) mmol/L,혈린(2.1±0.6)mmol/L,혈청기산격매(CK)、유산탈경매(LDH)、천동안산전안매(AST)분별위309(126 ～10 046)U/L、279(131 ～741) U/L、27(17 ～ 467) U/L.25례기매정상환자중IHP 20례,PHP 5례；혈개(1.64±0.29) mmol/L,혈린(2.2±0.6)mmol/L; CK(124±45) U/L,LDH(189 ±22) U/L,AST(25.6 ±7.3)U/L.16례HP기매증고환자치료전후기매진행비교,기매수평균수혈개농도적승고명현강저.HP환자적CK(r=-0.82)、LDH(r=-0.55)、AST(r=-0.56)적증고여혈개농도정부상관(균P＜0.05)；여년령、성별、병정、혈청린、PTH균무상관성(P＞0.05).결론 HP환자적기매증고여혈청개정부상관,여년령、성별、병정、혈청린、PTH균무상관성；차각충매학적변화수착혈개수평적정상이축점회복.
Objective To examine the clinical features of hypoparathyroidism (HP) with altered serum muscle enzymes and explore the correlations with age,gender,disease duration,serum total calcium,serum total phosphorus and parathyroid hormone (PTH).Methods From January 2005 to October 2011,a total of 41 HP patients at our hospital were retrospectively analyzed.Results There were 16 patients with elevated serum muscle enzymes and 25 with normal serum muscle enzymes.The former group included 11 patients of idiopathic hypoparathyroidism (IHP) and 5 of pseudohypoparathyroidism (PHP) ; serum calcium was (1.53 ± 0.25) mmol/L and serum phosphorus (2.1 ± 0.6) mmol/L; medians of creatine kinase (CK),lactic dehydrogenase (LDH),aspartate amino transfer enzymes (AST) were 309(126-10 046),279(131-741) and 27 (17-467) U/L in HP patients respectively.And the latter group included 20 IHP patients and 5 PHP ones ; serum calcium was (1.64 ± 0.29) mmol/L and serum phosphorus (2.2 ± 0.6) mmol/L.The levels of serum muscle enzyme were compared before and after treatment in the former group.And they significantly declined with the rising serum level of calcium after treatment.The serum levels of CK (r =-0.82),LDH(r =-0.55) and AST(r =-0.56) in HP patients with elevated serum muscle enzymes had a negative correlation with the serum level of calcium (all P ＜ 0.05).And there was no correlation with age,gender,disease duration or serum total phosphorus (P ＞ 0.05).Conclusion Elevated serum muscle enzymes in HP patients have a negative correlation with serum level of calcium and there is no correlation with age,gender,disease duration,serum total phosphorus or parathyroid hormone.And elevated serum muscle enzymes are gradually restored with the normalized serum level of calcium.
