CAJ | 학술논문

目的获得妊娠中期胎脑的三维可视化模型及正常测量值,分析其与孕龄的变化趋势及性别与半球间差异.方法 69例12 ～ 22周胎儿,进行7.0T MR扫描.分析胎脑的发育状况,并应用Amira4.1软件进行分割并三维重建.结果 22周时,除中央后沟与顶内沟外,其他脑沟均可分辨,但均未发出次级分支.12周时即可分辨出层状结构,16周后发育典型,呈现为信号不同的堆积条带.16周后基底核团与其间界线显示清晰.小脑原裂与齿状核此时也可辨认,20周时,小脑已具备典型成人外观.三维重建图像上,基底核、侧脑室与皮质表面脑沟显示清楚.胎脑测量值与孕龄呈现直线增长,速度不一.未发现结果存在性别与半球间差异.结论 12 ～ 22周时,胎脑正处于初始发育阶段.7.0T标本MRI可以较好的显示此时的胎脑结构.三维可视化与定量分析对幼稚脑结构的宏观认识有大的帮助.
목적 획득임신중기태뇌적삼유가시화모형급정상측량치,분석기여잉령적변화추세급성별여반구간차이.방법 69례12 ～ 22주태인,진행7.0T MR소묘.분석태뇌적발육상황,병응용Amira4.1연건진행분할병삼유중건.결과 22주시,제중앙후구여정내구외,기타뇌구균가분변,단균미발출차급분지.12주시즉가분변출층상결구,16주후발육전형,정현위신호불동적퇴적조대.16주후기저핵단여기간계선현시청석.소뇌원렬여치상핵차시야가변인,20주시,소뇌이구비전형성인외관.삼유중건도상상,기저핵、측뇌실여피질표면뇌구현시청초.태뇌측량치여잉령정현직선증장,속도불일.미발현결과존재성별여반구간차이.결론 12 ～ 22주시,태뇌정처우초시발육계단.7.0T표본MRI가이교호적현시차시적태뇌결구.삼유가시화여정량분석대유치뇌결구적굉관인식유대적방조.
Objective To obtain the three dimensional visualization model with normal measurements of fetal brain in the second trimester and analyze the developmental changes with gestational age (GA),sexual dimorphisms and cerebral asymmetries.Methods The brains of 69 fetal specimens of 12-22 weeks GA were scanned by 7.0T magnetic resonance imaging (MRI).The developing structures were analyzed and a three dimensional visualization model was rebuilt with Amira 4.1 software.Results Most sulci,except for postcentral and intraparietal sulcus,were present until 22 weeks GA.And none developed secondary branches.Laminar organization,described as early as 12 weeks GA,was delineated as layers with different signal intensities and became typical after 16 weeks GA.Basal nuclei was distinctly visible.Brains had different growth rates linearly increasing with GA.But neither sexual dimorphisms nor cerebral asymmetries was detected.Conclusions The initial developmental stage of fetal brain occurs at 12-22 weeks GA.The developing structures may be distinctly visualized on 7.0T post-mortem MRI.And the three dimensional visualization model aids greatly in the precise cognition of immature brain.