CAJ | 학술논문

目的评价计算流体力学技术在主动脉弓血流动力学研究中的应用价值.方法采用CT血管造影医学影像学技术获得个体患者原始主动脉血流图像,运用计算流体力学方法适量设定边界条件以重建主动脉弓精确解剖3D模型,并对管腔内血流速度、剪切力和壁应力等血流动力学因素进行数值模拟.结果高分辨率数值模拟可以精确仿真人体主动脉解剖学结构,该模型在功能上可以有效推演主动脉血流动力学环境变化过程.(1)主动脉弓内血流速度、剪切力和壁应力存在时空上的分布差异,收缩期的单向高速血流会被舒张期的多处涡流所替代,流速和剪切力的基本分布趋势从大弯向小弯逐渐升高,血管分支和降主动脉扭曲等解剖因素的影响较大；(2)升主动脉壁应力较主动脉弓、降主动脉有更大的量值和波动幅度,同一截面外侧壁应力高于内侧壁,在整个心动周期中动脉韧带对应的降主动脉外侧壁区域应力量值和波动最小.结论应用计算流体力学技术进行主动脉弓血流动力学研究,能够较真实的体外模拟主动脉血液流态和管壁应力特征,为主动脉疾病病因探索和虚拟诊疗系统的建立提供便捷和专业的实用工具.
목적 평개계산류체역학기술재주동맥궁혈류동역학연구중적응용개치.방법 채용CT혈관조영의학영상학기술획득개체환자원시주동맥혈류도상,운용계산류체역학방법괄량설정변계조건이중건주동맥궁정학해부3D모형,병대관강내혈류속도、전절력화벽응력등혈류동역학인소진행수치모의.결과 고분변솔수치모의가이정학방진인체주동맥해부학결구,해모형재공능상가이유효추연주동맥혈류동역학배경변화과정.(1)주동맥궁내혈류속도、전절력화벽응력존재시공상적분포차이,수축기적단향고속혈류회피서장기적다처와류소체대,류속화전절력적기본분포추세종대만향소만축점승고,혈관분지화강주동맥뉴곡등해부인소적영향교대；(2)승주동맥벽응력교주동맥궁、강주동맥유경대적량치화파동폭도,동일절면외측벽응력고우내측벽,재정개심동주기중동맥인대대응적강주동맥외측벽구역응역량치화파동최소.결론 응용계산류체역학기술진행주동맥궁혈류동역학연구,능구교진실적체외모의주동맥혈액류태화관벽응력특정,위주동맥질병병인탐색화허의진료계통적건립제공편첩화전업적실용공구.
Objective To evaluate the application of computational fluid dynamics (CFD) on a patient-specific hemodynamic model of aortic arch.Methods The original Dicom format image data of a patient were acquired by computed tomographic angiography (CTA).A 3-dimensional (3D) model based on CFD was constructed through the right amount of boundary conditions and hemodynamic parameters related with flow velocity,shear force and wall stress on lumen were analyzed accordingly.Results The 3D model based on CFD could reflect the characteristic of flow velocity,shear force and wall stress on lumen in vitro.(1) The distributions of hemodynamic variables during cardiac cycle were spatiotemporally different.The unidirectional high-speed systolic current was replaced by diastolic eddy current and reversed flow.The distribution of flow velocity and shear stress gradually increased from outer wall of aortic artery to inner wall under the influences of such anatomical factors as vascular branching and distortions of descending aorta; (2) the magnitude and volatility of wall stress in ascending aorta were greater than those of aortic arch and descending aorta,but the least results were at the lateral wall of descending aorta area.In addition,the wall stress of external wall was higher than the lateral wall in the same section.Conclusion The hemodynamic research of aortic arch based on CFD may actually simulate the characteristics of blood flow and wall stress so as to become a new reliable and convenient application tool in etiological diagnosis and surgical planning.