CAJ | 학술논문

目的探讨狼疮肠炎患者的临床和实验室特点.方法对2004至2011年于中山大学附属第一医院住院并出现急性腹痛的系统性红斑狼疮患者进行分组对照研究,狼疮肠炎组66例,非狼疮本身相关腹痛组73例.研究因素包括患者人口数据、实验室数据、临床和影像学数据.结果狼疮肠炎是狼疮患者急性腹痛最常见原因,占39.3％(66/168).在两组间自身抗体谱、补体、ESR、CRP、SLEDAI评分差异均无统计学意义.狼疮肠炎组的D-Ⅱ聚体水平和ECLAM评分明显高于非狼疮本身所致腹痛组.狼疮肠炎组较非狼疮本身所致腹痛组明显更多合并多浆膜腔积液和腹水.经Logistic回归分析,仅D-Ⅱ聚体水平、ECLAM评分和腹水量的分级被回归方程接纳,为有意义的相关因素.结论狼疮肠炎是狼疮急性腹痛常见的原因；D-Ⅱ聚体水平是狼疮肠炎有意义的临床预测因素.相对于SLEDAI,ECLAM更适用于狼疮消化道损害患者的评估.
목적 탐토랑창장염환자적림상화실험실특점.방법 대2004지2011년우중산대학부속제일의원주원병출현급성복통적계통성홍반랑창환자진행분조대조연구,랑창장염조66례,비랑창본신상관복통조73례.연구인소포괄환자인구수거、실험실수거、림상화영상학수거.결과 랑창장염시랑창환자급성복통최상견원인,점39.3％(66/168).재량조간자신항체보、보체、ESR、CRP、SLEDAI평분차이균무통계학의의.랑창장염조적D-Ⅱ취체수평화ECLAM평분명현고우비랑창본신소치복통조.랑창장염조교비랑창본신소치복통조명현경다합병다장막강적액화복수.경Logistic회귀분석,부D-Ⅱ취체수평、ECLAM평분화복수량적분급피회귀방정접납,위유의의적상관인소.결론 랑창장염시랑창급성복통상견적원인；D-Ⅱ취체수평시랑창장염유의의적림상예측인소.상대우SLEDAI,ECLAM경괄용우랑창소화도손해환자적평고.
Objective To explore the clinical and laboratory characteristics of patients with lupus enteritis to provide rationales for clinical diagnosis and treatment.Methods A retrospective group control study was conducted for systemic lupus erythematosus (SLE) patients with complaints of acute abdominal pain from 2004 to 2011.They were divided into 2 groups:lupus enteritis (n =66) and non-lupus related abdominal pain(n =73).The associated factors included demographic,laboratory,clinical and radiographic data.Results Lupus enteritis (39.3％) was the most common cause of lupus patients with acute abdominal pain.There were no differences in autoantibody profiles,complement,erythrocyte sedimentation rate,C reactive protein and SLE disease activity index (SLEDAI) score between two groups.The level of D-dimer and European consensus lupus activity measurement (ECLAM) score were significantly higher in the group of lupus enteritis than those in non-lupus related gastrointestinal injury.Lupus enteritis had significantly higher percentage of complications with multiple serous cavity effusions and ascites.But after adjusting with logistic regression multivariate analysis,only the level of D-dimer,ECLAM and volume of ascites were associated with occurrence of lupus enteritis.Conclusion Lupus enteritis is the most common cause of acute abdominal pain.D-dimer is an excellent predictor for lupus abdominal pain.As compared with SLEDAI,ECLAM may be more suitable for assessment in SLE patients with alimentary tract injury.