CAJ | 학술논문

目的分析2010年6月-2012年2月的流感样病例(ILI)病原学资料,探讨成人散发ILI病原谱特征.方法采集502例ILI患者的咽拭子标本.279例用多重PCR检测12种呼吸道病毒；413例用细胞培养法分离鉴定流感病毒,进行统计分析.结果多重PCR法中26.9％ (75/279)病例检出呼吸道病毒,甲型流感病毒(FLU-A)是2010-2011年流行优势株,占病毒阳性病例85.3％,占ILI的22.9％(64/279).其他呼吸道病毒阳性率低于3％.413例细胞培养分离的ILI中,新甲型H1N1(pH1N1)阳性率2.7％(11/413),H3阳性率2.4％(10/413),乙型流感病毒(FLU-B)阳性率6.5％ (27/413).2010-2011年优势株为FLU-A,2011-2012年优势株为FLU-B.2009-2012年流感流行高峰分别出现在2009年11月、2011年1月和2012年1～2月,2010和2011年的ILI％整体低于2009年同期水平.结论 pH1N1对流感季节性无影响.甲流过后散发ILI的病原以流感病毒为主.高峰在次年1～2月份.
목적 분석2010년6월-2012년2월적류감양병례(ILI)병원학자료,탐토성인산발ILI병원보특정.방법 채집502례ILI환자적인식자표본.279례용다중PCR검측12충호흡도병독；413례용세포배양법분리감정류감병독,진행통계분석.결과 다중PCR법중26.9％ (75/279)병례검출호흡도병독,갑형류감병독(FLU-A)시2010-2011년류행우세주,점병독양성병례85.3％,점ILI적22.9％(64/279).기타호흡도병독양성솔저우3％.413례세포배양분리적ILI중,신갑형H1N1(pH1N1)양성솔2.7％(11/413),H3양성솔2.4％(10/413),을형류감병독(FLU-B)양성솔6.5％ (27/413).2010-2011년우세주위FLU-A,2011-2012년우세주위FLU-B.2009-2012년류감류행고봉분별출현재2009년11월、2011년1월화2012년1～2월,2010화2011년적ILI％정체저우2009년동기수평.결론 pH1N1대류감계절성무영향.갑류과후산발ILI적병원이류감병독위주.고봉재차년1～2월빈.
Objective To analyze the results of detection on respiratory virus of influenza-like illness (ILI) in Beijing from June 2010 to February 2012 and understand the virus spectrum of adult influenza-like fever.Methods A total of 502 swabs were collected and 279 throat swabs tested for 12 respiratory viruses with multiplex reverse transcription-polymerase chain reaction (RT-PCR).And 413 swabs were tested for pH1N1 by virus isolation influenza viruses.And the data were statistically analyzed.Results One or two viruses were detected in 26.9％ (75/279) of the samples.Influenza A virus (FLUA) accounted for 85.3％ of positive samples and 22.9％ (64/279) of ILI tested.The positive rate of other viruses was less than 3.0 ％.The positive rates among the following subtypes were:2.7％ (11/413) for pH1N1,2.4％ (10/413) for H3 and 6.5％ (27/413) for FLU-B.FLU-A was the predominant virus during the 2010-2011 influenza season and the positive rate peaked in January 2011 in Beijing and north China.FLU-B was the primary virus during the 2011-2012 influenza season and the positive rate peaked in January and February 2012.There was a significant reduction in the incidence of ILI in 2010 and 2011 when compared with 2009.During the 2009-2012 influenza seasons,the incidence peaked in December 2009,January 2011 and January and February 2012 in Beijing.Conclusion Exposure to pH1N1 had no impact on typical influenza seasonal peaks.Influenza virus was the predominant virus of adult influenza-like fever cases after the pandemic period of influenza A (H1N1) 2009 and the positive rate peaked in January and February during the 2009-2012 influenza seasons.